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Bioorganic and medicinal Chemistry
Bioorganic and medicinal Chemistry
Novel rhenium complexes derived from α-tropanol as potential ligands for the dopamine transporter
Organic Chemistry / X Rays / Dopamine Transporter / Bioorganic and medicinal Chemistry / Binding affinity
Cyclic urea derivatives as potent NK1 selective antagonists
Organic Chemistry / Macromolecular X-Ray Crystallography / Animals / Urea / Fluorine / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Biological Availability / Heterocyclic compounds / Molecular Structure / Neurokinin receptor antagonists / Motor activity / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Biological Availability / Heterocyclic compounds / Molecular Structure / Neurokinin receptor antagonists / Motor activity
Synthesis of polyhalo acridones as pH-sensitive fluorescence probes
Organic Chemistry / Fluorescent Dyes and Reagents / Humans / Fluorescent probes / Bioorganic and medicinal Chemistry / Hydrogen-Ion Concentration / Antineoplastic Agents / Sulfuric Acid / Hydrogen-Ion Concentration / Antineoplastic Agents / Sulfuric Acid
Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors
Organic Chemistry / HIV / Cell line / Humans / Selection Index / Pyridines / Bioorganic and medicinal Chemistry / Imidazoles / Structure activity Relationship / Reverse Transcriptase / Cell Survival / Molecular Structure / Pyridines / Bioorganic and medicinal Chemistry / Imidazoles / Structure activity Relationship / Reverse Transcriptase / Cell Survival / Molecular Structure
Synthesis of 13-amino costunolide derivatives as anticancer agents
Organic Chemistry / Pharmaceutical Chemistry / Cell line / Humans / Mice / Animals / Drug Design / Sesquiterpenes / Bioorganic and medicinal Chemistry / Indexation / Antineoplastic Agents / Animals / Drug Design / Sesquiterpenes / Bioorganic and medicinal Chemistry / Indexation / Antineoplastic Agents
New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from< i> Gynostemma pentaphyllum</i>
Organic Chemistry / Traditional Medicine / Saponins / Energy Metabolism / Western blotting / Metabolic Bone Disease / Glucose / Fatty acids / Mice / Animals / Lipid metabolism / Bioorganic and medicinal Chemistry / Glucose Uptake / Plasma Membrane / Glycosides / Molecular Structure / Triterpenes / Plant Leaves / Metabolic Bone Disease / Glucose / Fatty acids / Mice / Animals / Lipid metabolism / Bioorganic and medicinal Chemistry / Glucose Uptake / Plasma Membrane / Glycosides / Molecular Structure / Triterpenes / Plant Leaves
New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum
Organic Chemistry / Traditional Medicine / Saponins / Energy Metabolism / Western blotting / Metabolic Bone Disease / Glucose / Fatty acids / Mice / Animals / Lipid metabolism / Bioorganic and medicinal Chemistry / Glucose Uptake / Plasma Membrane / Glycosides / Molecular Structure / Triterpenes / Plant Leaves / Metabolic Bone Disease / Glucose / Fatty acids / Mice / Animals / Lipid metabolism / Bioorganic and medicinal Chemistry / Glucose Uptake / Plasma Membrane / Glycosides / Molecular Structure / Triterpenes / Plant Leaves
Cyclic urea derivatives as potent NK1 selective antagonists
Organic Chemistry / Macromolecular X-Ray Crystallography / Animals / Urea / Fluorine / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Biological Availability / Heterocyclic compounds / Molecular Structure / Neurokinin receptor antagonists / Motor activity / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Biological Availability / Heterocyclic compounds / Molecular Structure / Neurokinin receptor antagonists / Motor activity
Synthesis of 13-amino costunolide derivatives as anticancer agents
Organic Chemistry / Pharmaceutical Chemistry / Cell line / Humans / Mice / Animals / Drug Design / Sesquiterpenes / Bioorganic and medicinal Chemistry / Indexation / Antineoplastic Agents / Animals / Drug Design / Sesquiterpenes / Bioorganic and medicinal Chemistry / Indexation / Antineoplastic Agents
Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase
Organic Chemistry / Enzyme Inhibitors / Humans / Mice / Blood Pressure / Animals / Male / Drug Design / Solubility / Time Factors / Functional Group / Bioorganic and medicinal Chemistry / Structure activity Relationship / Adamantane / Physical Properties / Molecular Structure / Animals / Male / Drug Design / Solubility / Time Factors / Functional Group / Bioorganic and medicinal Chemistry / Structure activity Relationship / Adamantane / Physical Properties / Molecular Structure
Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen
Organic Chemistry / Enzyme Inhibitors / Humans / Drug Design / Thiourea / Enzyme / Bioorganic and medicinal Chemistry / In Silico / Protein Binding / Enzyme / Bioorganic and medicinal Chemistry / In Silico / Protein Binding
Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents
Organic Chemistry / Humans / Molecular docking / Chagas disease / Enzyme / Trypanosoma Cruzi / Cysteine endopeptidases / Molecular Conformation / Bioorganic and medicinal Chemistry / Trypanocidal Agents / Erythrocytes / Cysteine Proteinase Inhibitors / Trypanosoma Cruzi / Cysteine endopeptidases / Molecular Conformation / Bioorganic and medicinal Chemistry / Trypanocidal Agents / Erythrocytes / Cysteine Proteinase Inhibitors
Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors
Organic Chemistry / Nitriles / Protease Inhibitors / Cyclization / Bioorganic and medicinal Chemistry / Type 2 Diabetes Mellitus / Structure activity Relationship / Molecular Structure / Type 2 Diabetes Mellitus / Structure activity Relationship / Molecular Structure
4′-α-C-Branched N,O-nucleosides: synthesis and biological properties
Organic Chemistry / Magnetic Resonance Spectroscopy / Apoptosis / Cell line / Humans / Vinyl acetate / Bioorganic and medicinal Chemistry / Antiviral Activity / Nucleosides / Antiviral Agents / Vinyl acetate / Bioorganic and medicinal Chemistry / Antiviral Activity / Nucleosides / Antiviral Agents
Quinol derivatives as potential trypanocidal agents
Organic Chemistry / Cell line / Humans / Drug Delivery Systems / Trypanosoma brucei brucei / Bioorganic and medicinal Chemistry / Trypanocidal Agents / Triazines / Molecular Structure / Bioorganic and medicinal Chemistry / Trypanocidal Agents / Triazines / Molecular Structure
4′-α-C-Branched N,O-nucleosides: synthesis and biological properties
Organic Chemistry / Magnetic Resonance Spectroscopy / Apoptosis / Cell line / Humans / Vinyl acetate / Bioorganic and medicinal Chemistry / Antiviral Activity / Nucleosides / Antiviral Agents / Vinyl acetate / Bioorganic and medicinal Chemistry / Antiviral Activity / Nucleosides / Antiviral Agents
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