Bioorganic and medicinal Chemistry

Polyacylated neohesperidosides From Geranium caespitosum: bacterial multidrug resistance pump inhibitors

Organic Chemistry / Multidrug Resistance / Staphylococcus aureus / Membrane transport proteins / Anti-Bacterial Agents / Bacillus subtilis / Bacillus megaterium / Microbial Sensitivity Tests / Acylation / Bioorganic and medicinal Chemistry / Hesperidin / Geranium / Bacillus subtilis / Bacillus megaterium / Microbial Sensitivity Tests / Acylation / Bioorganic and medicinal Chemistry / Hesperidin / Geranium

Selective A3 adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system

Algorithms / Organic Chemistry / Molecular modeling / Free Radical / Humans / cyclic AMP / Animals / Guanosine Triphosphate / Radioligand Assay / Bioorganic and medicinal Chemistry / Nucleosides / Structure activity Relationship / Ribose / cyclic AMP / Animals / Guanosine Triphosphate / Radioligand Assay / Bioorganic and medicinal Chemistry / Nucleosides / Structure activity Relationship / Ribose

Bacterial diaminopimelate metabolism as a target for antibiotic design

Organic Chemistry / Bioorganic and medicinal Chemistry

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: A new class of CDK2 inhibitors

Organic Chemistry / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Humans / Bioorganic and medicinal Chemistry / Cell Proliferation / Pyrazoles / Aurora kinases / Structure activity Relationship / Antineoplastic Agents / Molecular Structure / Cell Proliferation / Pyrazoles / Aurora kinases / Structure activity Relationship / Antineoplastic Agents / Molecular Structure

Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

Organic Chemistry / Magnetic Resonance Spectroscopy / Phenols / Radioligand Assay / Bioorganic and medicinal Chemistry / Biological activity / Structure activity Relationship / Piperidines / Biological activity / Structure activity Relationship / Piperidines

Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

Organic Chemistry / Amides / Bioorganic and medicinal Chemistry / Biological activity / Benzimidazoles / Structure activity Relationship / Molecular Structure / Formalin Test / Structure activity Relationship / Molecular Structure / Formalin Test

Oxamides as novel NR2B selective NMDA receptor antagonists

Organic Chemistry / Mice / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Formalin Test / Molecular Structure / Formalin Test

Potent 4-amino-5-azaindole factor VIIa inhibitors

Organic Chemistry / Pyridines / Bioorganic and medicinal Chemistry / Structure activity Relationship / Serine Protease / Tissue Factor / Molecular Structure / Tissue Factor / Molecular Structure

N-1H-Benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists

Organic Chemistry / Drug metabolism / Nuclear Receptor / Cell line / Humans / Drug Design / Enzyme / Bioorganic and medicinal Chemistry / Primary Culture / Benzimidazoles / Human Disease / Structure activity Relationship / Chemical Modification / Molecular Structure / Gene Expression Regulation / Pregnane X Receptor / Drug Design / Enzyme / Bioorganic and medicinal Chemistry / Primary Culture / Benzimidazoles / Human Disease / Structure activity Relationship / Chemical Modification / Molecular Structure / Gene Expression Regulation / Pregnane X Receptor

A new class of compounds, peptide derivatives of adenosine 5′-carboxylic acid, includes inhibitors of ATP receptor-mediatedresponses

Organic Chemistry / Calcium / Signal Transduction / Adenosine / Mice / Animals / Male / Peptides / Carboxylic Acids / Bioorganic and medicinal Chemistry / Adenosine Triphosphate / Animals / Male / Peptides / Carboxylic Acids / Bioorganic and medicinal Chemistry / Adenosine Triphosphate

Natural ozone scavenger prevents asthma in sensitized rats

Organic Chemistry / Asthma / Animals / Male / Terpenes / Lung / Rats / Ozone / Pulmonary Function / Bioorganic and medicinal Chemistry / Rat Model / Monoterpenes / White Blood Cell / Molecular Structure / Lung / Rats / Ozone / Pulmonary Function / Bioorganic and medicinal Chemistry / Rat Model / Monoterpenes / White Blood Cell / Molecular Structure

Phenylacetic acid derivatives as hPPAR agonists

Organic Chemistry / Transcription Factors / Insulin Resistance / Blood Glucose / Mice / Animals / Male / Drug Design / Triglycerides / Rats / Oral Hypoglycemic Agents / Bioorganic and medicinal Chemistry / Thiazoles / Animals / Male / Drug Design / Triglycerides / Rats / Oral Hypoglycemic Agents / Bioorganic and medicinal Chemistry / Thiazoles

Fmoc-protected iminosugar modified asparagine derivatives as building blocks for glycomimetics-containing peptides

Organic Chemistry / Multiple sclerosis / Glycopeptide Research / Humans / Statistical Significance / Peptides / Liquid Chromatography / Electrospray Ionization Mass Spectrometry / Secondary Structure / Antibody / Molecular Mimicry / Protein Conformation / Bioorganic and medicinal Chemistry / Asparagine / Chemical Synthesis / Enzyme Linked Immunosorbent Assay / Autoantibodies / Peptides / Liquid Chromatography / Electrospray Ionization Mass Spectrometry / Secondary Structure / Antibody / Molecular Mimicry / Protein Conformation / Bioorganic and medicinal Chemistry / Asparagine / Chemical Synthesis / Enzyme Linked Immunosorbent Assay / Autoantibodies

Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells

Organic Chemistry / Prostate Cancer / Humans / Male / Organoselenium Compounds / Bioorganic and medicinal Chemistry / Cell Proliferation / Antitumor Activity / Structure activity Relationship / Carbamates / Molecular Structure / Bioorganic and medicinal Chemistry / Cell Proliferation / Antitumor Activity / Structure activity Relationship / Carbamates / Molecular Structure

Structure-based design of indole propionic acids as novel PPARα/γ co-agonists

Organic Chemistry / X Rays / Propionic Acid / Drug Design / X ray diffraction / Bioorganic and medicinal Chemistry / Type 2 Diabetes Mellitus / Structure activity Relationship / Complex Structure / Nuclear hormone receptor / Molecular Structure / Bioorganic and medicinal Chemistry / Type 2 Diabetes Mellitus / Structure activity Relationship / Complex Structure / Nuclear hormone receptor / Molecular Structure

Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors

Organic Chemistry / Schizophrenia / Structure / Modeling / Macromolecular X-Ray Crystallography / In Vitro / Permeability / Animals / Phosphodiesterase Inhibitors / Rats / Molecular Model / Bioorganic and medicinal Chemistry / Benzimidazoles / Protein Binding / Chemical Synthesis / Molecular Structure / Quinazolines / In Vitro / Permeability / Animals / Phosphodiesterase Inhibitors / Rats / Molecular Model / Bioorganic and medicinal Chemistry / Benzimidazoles / Protein Binding / Chemical Synthesis / Molecular Structure / Quinazolines

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