Bioorganic and medicinal Chemistry

Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors

Organic Chemistry / Schizophrenia / Structure / Modeling / Macromolecular X-Ray Crystallography / In Vitro / Permeability / Animals / Phosphodiesterase Inhibitors / Rats / Molecular Model / Bioorganic and medicinal Chemistry / Benzimidazoles / Protein Binding / Chemical Synthesis / Molecular Structure / Quinazolines / In Vitro / Permeability / Animals / Phosphodiesterase Inhibitors / Rats / Molecular Model / Bioorganic and medicinal Chemistry / Benzimidazoles / Protein Binding / Chemical Synthesis / Molecular Structure / Quinazolines

Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators

Organic Chemistry / Mass Spectrometry / Magnetic Resonance Spectroscopy / Humans / Female / Animals / Bioorganic and medicinal Chemistry / Aorta / Animals / Bioorganic and medicinal Chemistry / Aorta

A novel amino-benzosuberone derivative is a picomolar inhibitor of mammalian aminopeptidase N/CD13

Organic Chemistry / Kinetics / Enzyme Inhibitors / Kidney / Animals / Aeromonas / Swine / Bioorganic and medicinal Chemistry / Structure activity Relationship / Low molecular weight / Molecular Structure / Aeromonas / Swine / Bioorganic and medicinal Chemistry / Structure activity Relationship / Low molecular weight / Molecular Structure

Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Organic Chemistry / Macromolecular X-Ray Crystallography / Mutation / Bioorganic and medicinal Chemistry

Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Organic Chemistry / Macromolecular X-Ray Crystallography / Mutation / Bioorganic and medicinal Chemistry

Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum

Organic Chemistry / Enzyme Inhibitors / Bacteria / Enzyme / High Resolution / Spectrum analysis / Polygonum Cuspidatum / Bioorganic and medicinal Chemistry / DNA primase / Spectrum analysis / Polygonum Cuspidatum / Bioorganic and medicinal Chemistry / DNA primase

Synthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors

Organic Chemistry / Enzyme Inhibitors / Magnetic Resonance Spectroscopy / Fourier transform infrared spectroscopy / Oral Hypoglycemic Agents / Bioorganic and medicinal Chemistry / Imidazoles / Structure activity Relationship / Molecular Structure / Acarbose / Bioorganic and medicinal Chemistry / Imidazoles / Structure activity Relationship / Molecular Structure / Acarbose

Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Organic Chemistry / Macromolecular X-Ray Crystallography / Mutation / Bioorganic and medicinal Chemistry

Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors

Organic Chemistry / Cancer / Levels of selection / Signal Transduction / Cell line / In Vitro / Humans / Amines / Caspase / Akt / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Selectivity / Piperidines / In Vitro / Humans / Amines / Caspase / Akt / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Selectivity / Piperidines

Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum

Organic Chemistry / Humans / Melanoma / Animals / Natural Product / Cattle / Cytotoxic Activity / Molecular Conformation / Bioorganic and medicinal Chemistry / Antineoplastic Agents / Macrolides / Cattle / Cytotoxic Activity / Molecular Conformation / Bioorganic and medicinal Chemistry / Antineoplastic Agents / Macrolides

Imidazo-pyrazine derivatives as potent CXCR3 antagonists

Organic Chemistry / Lung Inflammation / Humans / Mice / Animals / Anti-inflammatory agents / Rats / Molecular Conformation / Bioorganic and medicinal Chemistry / Imidazoles / Anti-inflammatory agents / Rats / Molecular Conformation / Bioorganic and medicinal Chemistry / Imidazoles

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Development of CXCR3 antagonists. Part 4: Discovery of 2-amino-(4-tropinyl)quinolines

Organic Chemistry / Mice / Animals / Bioorganic and medicinal Chemistry / Quinolines / Biological Availability / Physicochemical Properties / Area Under Curve / Biological Availability / Physicochemical Properties / Area Under Curve

Adamantane and Nipecotic Acid Derivatives as Novel β-Turn Mimics

Organic Chemistry / Bioorganic and medicinal Chemistry

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