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Bioorganic and medicinal Chemistry
Bioorganic and medicinal Chemistry
Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1
Organic Chemistry / Humans / Bioorganic and medicinal Chemistry / Molecular Structure
Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2
Organic Chemistry / Glucose / Animals / Rats / Bioorganic and medicinal Chemistry / Molecular Structure
Structure-based design of indole propionic acids as novel PPARα/γ co-agonists
Organic Chemistry / X Rays / Propionic Acid / Drug Design / Nuclear Hormone Receptors / X ray diffraction / PPAR / Bioorganic and medicinal Chemistry / Type 2 Diabetes Mellitus / Structure activity Relationship / Complex Structure / Nuclear hormone receptor / Molecular Structure / X ray diffraction / PPAR / Bioorganic and medicinal Chemistry / Type 2 Diabetes Mellitus / Structure activity Relationship / Complex Structure / Nuclear hormone receptor / Molecular Structure
Spirocyclopropyl pyrrolidines as a new series of α-l-fucosidase inhibitors
Organic Chemistry / Titanium / Enzyme Inhibitors / Kidney / Animals / Cattle / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Cattle / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship
Efficient parallel synthesis of macrocyclic peptidomimetics
Organic Chemistry / Pharmaceutical Chemistry / Silver / Peptides / Cyclic peptides / Molecular Mimicry / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Dimerization / Molecular Mimicry / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Dimerization
Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase
Organic Chemistry / Enzyme Inhibitors / Humans / Mice / Blood Pressure / Animals / Male / Drug Design / Solubility / Time Factors / Functional Group / Bioorganic and medicinal Chemistry / Structure activity Relationship / Adamantane / Physical Properties / Molecular Structure / Animals / Male / Drug Design / Solubility / Time Factors / Functional Group / Bioorganic and medicinal Chemistry / Structure activity Relationship / Adamantane / Physical Properties / Molecular Structure
Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1
Organic Chemistry / Modeling / Prediction / Pharmacokinetics / Molecular modeling / Cercopithecus aethiops / Cell line / In Vitro / Humans / Animals / Resonant Energy Transfer / Bioluminescence / In Vivo / Rats / Molecular Model / Water Solubility / Acetic Acid / ADME / Bioorganic and medicinal Chemistry / Thiazoles / In Silico / Structure activity Relationship / Protein Binding / Chemical Synthesis / Selectivity / Binding affinity / Cercopithecus aethiops / Cell line / In Vitro / Humans / Animals / Resonant Energy Transfer / Bioluminescence / In Vivo / Rats / Molecular Model / Water Solubility / Acetic Acid / ADME / Bioorganic and medicinal Chemistry / Thiazoles / In Silico / Structure activity Relationship / Protein Binding / Chemical Synthesis / Selectivity / Binding affinity
Synthetic biotinylated tetra β(1→5) galactofuranoside for in vitro aspergillosis diagnosis
Organic Chemistry / Serology / In Vitro / Allergy / Humans / Animals / Biotin / Aspergillus fumigatus / Rats / Diagnostic Test / Bioorganic and medicinal Chemistry / Monoclonal Antibody / Aspergillosis / Biotinylation / Animals / Biotin / Aspergillus fumigatus / Rats / Diagnostic Test / Bioorganic and medicinal Chemistry / Monoclonal Antibody / Aspergillosis / Biotinylation
Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors
Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Homocysteine / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis
Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors
Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Homocysteine / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis
Fmoc-protected iminosugar modified asparagine derivatives as building blocks for glycomimetics-containing peptides
Organic Chemistry / Multiple sclerosis / Glycopeptide Research / Humans / Statistical Significance / Peptides / Liquid Chromatography / Electrospray Ionization Mass Spectrometry / Secondary Structure / Antibody / Molecular Mimicry / Protein Conformation / Bioorganic and medicinal Chemistry / Asparagine / Chemical Synthesis / Enzyme Linked Immunosorbent Assay / Autoantibodies / Peptides / Liquid Chromatography / Electrospray Ionization Mass Spectrometry / Secondary Structure / Antibody / Molecular Mimicry / Protein Conformation / Bioorganic and medicinal Chemistry / Asparagine / Chemical Synthesis / Enzyme Linked Immunosorbent Assay / Autoantibodies
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors
Organic Chemistry / Signal Transduction / Cell line / In Vitro / Humans / Computer Simulation / Phosphorylation / Bioorganic and medicinal Chemistry / Growth Inhibition / Chemical Synthesis / Protein Kinase Inhibitors / Adenosine Triphosphate / Computer Simulation / Phosphorylation / Bioorganic and medicinal Chemistry / Growth Inhibition / Chemical Synthesis / Protein Kinase Inhibitors / Adenosine Triphosphate
Bacterial diaminopimelate metabolism as a target for antibiotic design
Organic Chemistry / Bioorganic and medicinal Chemistry
Kojic acid–amino acid conjugates as tyrosinase inhibitors
Bioinformatics / Organic Chemistry / Kinetics / Modeling / Prediction / Enzyme Inhibitors / Stability / Genetic Algorithm / Enzyme Kinetics / In Vitro / Computer Simulation / Kojic Acid / Search Algorithm / Amino Acids / Molecular Model / Amino Acid Profile / Bioorganic and medicinal Chemistry / Enzyme Inhibitors / Stability / Genetic Algorithm / Enzyme Kinetics / In Vitro / Computer Simulation / Kojic Acid / Search Algorithm / Amino Acids / Molecular Model / Amino Acid Profile / Bioorganic and medicinal Chemistry
Potent 4-amino-5-azaindole factor VIIa inhibitors
Organic Chemistry / PT / Pyridines / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Serine Protease / Tissue Factor / Molecular Structure / Selectivity / Chemical Synthesis / Serine Protease / Tissue Factor / Molecular Structure / Selectivity
A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands
Organic Chemistry / Kinetics / Pharmaceutical Chemistry / Humans / Drug Design / Serotonin Receptors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Ligands / Molecular Structure / Tryptamines / Serotonin Receptors / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Ligands / Molecular Structure / Tryptamines
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