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Bioorganic and medicinal Chemistry
Bioorganic and medicinal Chemistry
Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors
Organic Chemistry / Drug Discovery / Humans / Metabolic diseases / Mice / Animals / Lipid metabolism / Rats / Bioorganic and medicinal Chemistry / Triazoles / Structure activity Relationship / Stearoyl-CoA desaturase / Animals / Lipid metabolism / Rats / Bioorganic and medicinal Chemistry / Triazoles / Structure activity Relationship / Stearoyl-CoA desaturase
Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors
Organic Chemistry / Drug Discovery / Humans / Metabolic diseases / Mice / Animals / Lipid metabolism / Rats / Bioorganic and medicinal Chemistry / Triazoles / Structure activity Relationship / Stearoyl-CoA desaturase / Animals / Lipid metabolism / Rats / Bioorganic and medicinal Chemistry / Triazoles / Structure activity Relationship / Stearoyl-CoA desaturase
Discovery of a series of aminopiperidines as novel iNOS inhibitors
Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Amines / Blood Pressure / Drug Design / Active site / Nitric Oxide Synthase / Bioorganic and medicinal Chemistry / Structure activity Relationship / Isozyme / Chemical Synthesis / Selectivity / Piperidines / Blood Pressure / Drug Design / Active site / Nitric Oxide Synthase / Bioorganic and medicinal Chemistry / Structure activity Relationship / Isozyme / Chemical Synthesis / Selectivity / Piperidines
Discovery of a series of aminopiperidines as novel iNOS inhibitors
Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Amines / Blood Pressure / Drug Design / Active site / Nitric Oxide Synthase / Bioorganic and medicinal Chemistry / Structure activity Relationship / Isozyme / Chemical Synthesis / Selectivity / Piperidines / Blood Pressure / Drug Design / Active site / Nitric Oxide Synthase / Bioorganic and medicinal Chemistry / Structure activity Relationship / Isozyme / Chemical Synthesis / Selectivity / Piperidines
Diboronic acids as fluorescent probes for cells expressing sialyl lewis X
Organic Chemistry / Fluorescence / Gene expression / Cell Culture / Humans / Mice / Animals / Boronic Acids / Fluorescent probes / Bioorganic and medicinal Chemistry / Aqueous Solution / Molecular Structure / Oligosaccharides / Mice / Animals / Boronic Acids / Fluorescent probes / Bioorganic and medicinal Chemistry / Aqueous Solution / Molecular Structure / Oligosaccharides
IRAK-4 inhibitors. Part III: A series of imidazo[1,2-a]pyridines
Organic Chemistry / Signal Transduction / In Vitro / Kinase inhibitor / Pyridines / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure
IRAK-4 inhibitors. Part 1: A series of amides
Organic Chemistry / Enzyme Inhibitors / Humans / Drug Design / SAR / Solubility / Docking / Amides / Pyridines / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Suzuki Reaction / Solubility / Docking / Amides / Pyridines / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Suzuki Reaction
IRAK-4 inhibitors. Part III: A series of imidazo[1,2- a]pyridines
Organic Chemistry / Signal Transduction / In Vitro / Kinase inhibitor / Pyridines / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure
Efficient parallel synthesis of macrocyclic peptidomimetics
Organic Chemistry / Pharmaceutical Chemistry / Silver / Peptides / Cyclic peptides / Molecular Mimicry / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Dimerization / Molecular Mimicry / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Dimerization
Amino-caprolactam derivatives as γ-secretase inhibitors
Organic Chemistry / Enzyme Inhibitors / Bioorganic and medicinal Chemistry / Caprolactam
4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors
Organic Chemistry / Modeling / Pharmacokinetics / Pharmaceutical Chemistry / Signal Transduction / Crystal structure / X Rays / In Vitro / Humans / Animals / Drug Design / Kinase inhibitor / Design Rationale / In Vivo / Hydrazones / Rats / Oximes / Molecular Model / Molecular Conformation / Bioorganic and medicinal Chemistry / Growth Factor / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Receptor Tyrosine Kinase / Crystal structure / X Rays / In Vitro / Humans / Animals / Drug Design / Kinase inhibitor / Design Rationale / In Vivo / Hydrazones / Rats / Oximes / Molecular Model / Molecular Conformation / Bioorganic and medicinal Chemistry / Growth Factor / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Receptor Tyrosine Kinase
Structural requirement of arylindolylpropenones as anti-bladder carcinoma cells agents
Organic Chemistry / Flow Cytometry / Cell Cycle / Cell line / Bladder Cancer / Humans / Chalcones / Mode of action / Bioorganic and medicinal Chemistry / Structure activity Relationship / Antineoplastic Agents / Humans / Chalcones / Mode of action / Bioorganic and medicinal Chemistry / Structure activity Relationship / Antineoplastic Agents
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