Conformational Change

Development of a novel FRET immunosensor technique

Analytical Chemistry / Biomedical Engineering / Fluorescence / Nanotechnology / Fluorescence Resonance Energy Transfer / Biosensor / Technique / FRET / Resonant Energy Transfer / Protein Complex Detection / Antibody / Reproducibility of Results / Energy Transfer / Sensitivity and Specificity / Equipment Design / Equipment Failure Analysis / P/BV Ratio / Conformational Change / Antigens / Biosensing Techniques / immunoglobulin G / Biosensor / Technique / FRET / Resonant Energy Transfer / Protein Complex Detection / Antibody / Reproducibility of Results / Energy Transfer / Sensitivity and Specificity / Equipment Design / Equipment Failure Analysis / P/BV Ratio / Conformational Change / Antigens / Biosensing Techniques / immunoglobulin G

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Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation

Immunology / Immune response / Cell Biology / Mitochondria / Apoptosis / Signal Transduction / Caspases / Cell line / Allergy / Mitochondrial DNA / Humans / Reactive Oxygen Species / Mice / Animals / Cell Death / Cytochrome C / NADPH oxidase / Immunology & Cell Biology / Oxidative phosphorylation / Mitochondrial Membrane Potential / Conformational Change / Biochemistry and cell biology / Cytotoxic T cells / Immunoblotting / Signal Transduction / Caspases / Cell line / Allergy / Mitochondrial DNA / Humans / Reactive Oxygen Species / Mice / Animals / Cell Death / Cytochrome C / NADPH oxidase / Immunology & Cell Biology / Oxidative phosphorylation / Mitochondrial Membrane Potential / Conformational Change / Biochemistry and cell biology / Cytotoxic T cells / Immunoblotting

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Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target

Structure / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Tuberculosis / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data

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Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target

Structure / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Tuberculosis / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data

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Farnesyltransferase inhibitor BMS-214662 induces apoptosis in B-cell chronic lymphocytic leukemia cells

Membrane Proteins / Enzyme Inhibitors / Leukemia / Mitochondria / Molecular Pharmacology / Apoptosis / Caspases / Cell line / Humans / Chronic Lymphocytic Leukemia / Female / Multiple Myeloma / Male / Cell Death / Cytochrome C / Benzodiazepines / Clinical Sciences / Western blot / Heat Shock Proteins / Protein Conformation / B Lymphocytes / Imidazoles / Mitochondrial Membrane Potential / Antineoplastic Agents / Neurosciences / Conformational Change / Apoptosis / Caspases / Cell line / Humans / Chronic Lymphocytic Leukemia / Female / Multiple Myeloma / Male / Cell Death / Cytochrome C / Benzodiazepines / Clinical Sciences / Western blot / Heat Shock Proteins / Protein Conformation / B Lymphocytes / Imidazoles / Mitochondrial Membrane Potential / Antineoplastic Agents / Neurosciences / Conformational Change

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Structural Asymmetry in a Trimeric Na+/Betaine Symporter, BetP, from Corynebacterium glutamicum

Molecular Biology / EM / Macromolecular X-Ray Crystallography / Molecular / X Rays / Protein Secondary Structure Prediction / Sodium / Rigid Body / Three Dimensional / Atomic Structure / Osmotic Stress / Ion Transport / Glycine Betaine / Structure activity Relationship / D / Conformational Change / PDB / Biochemistry and cell biology / Cc / Betaine / Protein Secondary Structure Prediction / Sodium / Rigid Body / Three Dimensional / Atomic Structure / Osmotic Stress / Ion Transport / Glycine Betaine / Structure activity Relationship / D / Conformational Change / PDB / Biochemistry and cell biology / Cc / Betaine

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Transglutaminase 2: A molecular Swiss army knife

Medical Microbiology / Transcription Regulation / Extracellular Matrix / Biological Sciences / Humans / Animals / Cell Death / Physical sciences / Functional diversity / Gene Duplication / Subcellular Localization / Protein Conformation / Cell Proliferation / Structure activity Relationship / Cell Survival / Conformational Change / Gtp Binding Proteins / Biochemistry and cell biology / Transglutaminases / Animals / Cell Death / Physical sciences / Functional diversity / Gene Duplication / Subcellular Localization / Protein Conformation / Cell Proliferation / Structure activity Relationship / Cell Survival / Conformational Change / Gtp Binding Proteins / Biochemistry and cell biology / Transglutaminases

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Protein kinase C as a peripheral biomarker for Alzheimer’s disease

Humans / PKC / Amyloid Beta / Enzyme / Aged / Biomarker / Fluorescent probes / Biological markers / Red blood cell / Erythrocytes / Alzheimer Disease / Conformational Change / Blood cells / Biomarker / Fluorescent probes / Biological markers / Red blood cell / Erythrocytes / Alzheimer Disease / Conformational Change / Blood cells

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TCRalpha enhancer activation occurs via a conformational change of a pre-assembled nucleo-protein complex

Biological Sciences / DNA / Cell Differentiation / Mice / Animals / Genome / Nucleosomes / T lymphocytes / Protein Complex Detection / Molecular Conformation / B Lymphocytes / Base Sequence / DNA-footprinting / Conformational Change / Response Elements / Genome / Nucleosomes / T lymphocytes / Protein Complex Detection / Molecular Conformation / B Lymphocytes / Base Sequence / DNA-footprinting / Conformational Change / Response Elements

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Reactive oxygen species is essential for cycloheximide to sensitize lexatumumab-induced apoptosis in hepatocellular carcinoma cells

Drug interactions / Apoptosis / Multidisciplinary / Caspases / Cell line / Humans / Reactive Oxygen Species / Hepatocellular Carcinoma / Cell Death / Cytochrome C / Monoclonal Antibodies / PLoS one / Conformational Change / Intracellular Space / Cycloheximide / Humans / Reactive Oxygen Species / Hepatocellular Carcinoma / Cell Death / Cytochrome C / Monoclonal Antibodies / PLoS one / Conformational Change / Intracellular Space / Cycloheximide

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Structure of an oligonucleotide containing a N-(2-deoxy-β-D-erythro-pentofuranosyl)formamide residue facing a guanine

Nuclear Magnetic Resonance / Magnetic Resonance Spectroscopy / Molecular modeling / Hydrogen Bond / Biochimie / Ionizing Radiation / Oxidative Dna Damage / Conformational Change / Nucleic Acid Conformation / Oligonucleotides / Biochemistry and cell biology / Ionizing Radiation / Oxidative Dna Damage / Conformational Change / Nucleic Acid Conformation / Oligonucleotides / Biochemistry and cell biology

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TCRalpha enhancer activation occurs via a conformational change of a pre-assembled nucleo-protein complex

Biological Sciences / DNA / Cell Differentiation / Mice / Animals / Genome / Nucleosomes / T lymphocytes / Protein Complex Detection / Molecular Conformation / B Lymphocytes / Base Sequence / DNA-footprinting / Conformational Change / Response Elements / Molecular Sequence Data / Genome / Nucleosomes / T lymphocytes / Protein Complex Detection / Molecular Conformation / B Lymphocytes / Base Sequence / DNA-footprinting / Conformational Change / Response Elements / Molecular Sequence Data

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Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

Kinetics / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Humans / Endoplasmic Reticulum / Antigen Presentation / Special functions / CHEMICAL SCIENCES / Active site / Substrate Specificity / Structure activity Relationship / Conformational Change / Antigens / MHC class I / Endoplasmic Reticulum / Antigen Presentation / Special functions / CHEMICAL SCIENCES / Active site / Substrate Specificity / Structure activity Relationship / Conformational Change / Antigens / MHC class I

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Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation

Immunology / Immune response / Cell Biology / Mitochondria / Apoptosis / Signal Transduction / Caspases / Cell line / Allergy / Mitochondrial DNA / Humans / Reactive Oxygen Species / Mice / Animals / Cell Death / Cytochrome C / NADPH oxidase / Immunology & Cell Biology / Oxidative phosphorylation / Mitochondrial Membrane Potential / Conformational Change / Biochemistry and cell biology / Cytotoxic T cells / Immunoblotting / Signal Transduction / Caspases / Cell line / Allergy / Mitochondrial DNA / Humans / Reactive Oxygen Species / Mice / Animals / Cell Death / Cytochrome C / NADPH oxidase / Immunology & Cell Biology / Oxidative phosphorylation / Mitochondrial Membrane Potential / Conformational Change / Biochemistry and cell biology / Cytotoxic T cells / Immunoblotting

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Two Novel Spectroscopic Techniques: 2D Roa and 2D Raman/Roa

Raman Spectroscopy / Biological systems / Protein Conformation / Raman Scattering / Spectroscopic Techniques / Raman Spectra / Conformational Change / Raman Optical Activity / Spectral Resolution / Raman Spectra / Conformational Change / Raman Optical Activity / Spectral Resolution

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