DNA damage

Nuclear phosphoinositide 3-kinase β controls double-strand break DNA repair

DNA replication / DNA damage / DNA repair / Multidisciplinary / Mice / Animals / Cell nucleus / Neoplasms / Genomic instability / Protein isoforms / Cell Cycle Proteins / Animals / Cell nucleus / Neoplasms / Genomic instability / Protein isoforms / Cell Cycle Proteins

Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155

MicroRNA / Immunohistochemistry / DNA damage / DNA repair / In Situ Hybridization / Humans / Female / HIstone Deacetylase / Immunoprecipitation / microRNAs / Tumor Suppressor Gene / Microarray Analysis / Analysis of Variance / Chromatin Immunoprecipitation / Cell Cycle regulation / Humans / Female / HIstone Deacetylase / Immunoprecipitation / microRNAs / Tumor Suppressor Gene / Microarray Analysis / Analysis of Variance / Chromatin Immunoprecipitation / Cell Cycle regulation

The Cdc14B-Cdh1-Plk1 Axis Controls the G2 DNA-Damage-Response Checkpoint

DNA damage / DNA repair / Signal Transduction / Biological Sciences / Mitosis / Humans / Cell / Cell nucleus / DNA damage response / Neoplasms / Signaling / Cell Cycle Proteins / Humans / Cell / Cell nucleus / DNA damage response / Neoplasms / Signaling / Cell Cycle Proteins

Chronic oxidative DNA damage due to DNA repair defects causes chromosomal instability in Saccharomyces cerevisiae

Genetics / Oxidative Stress / DNA damage / DNA repair / Molecular Mechanics / Free Radical / Biological Sciences / High Frequency / Saccharomyces cerevisiae / Molecular and cellular biology / Reactive Oxygen Species / Nucleic acid hybridization / Gene Duplication / Time Factors / Oxidative Damage / Model System / Genetic Instability / Genomic instability / Genetic Recombination / Genome Rearrangement / Chronic Inflammation / Large Scale / Oxidative Dna Damage / Chromosomal Instability / Bacterial Infection / Diploidy / Mutation Rate / Base Excision Repair / Free Radical / Biological Sciences / High Frequency / Saccharomyces cerevisiae / Molecular and cellular biology / Reactive Oxygen Species / Nucleic acid hybridization / Gene Duplication / Time Factors / Oxidative Damage / Model System / Genetic Instability / Genomic instability / Genetic Recombination / Genome Rearrangement / Chronic Inflammation / Large Scale / Oxidative Dna Damage / Chromosomal Instability / Bacterial Infection / Diploidy / Mutation Rate / Base Excision Repair

Mitokondrium, oxidatív stressz és öregedés

Free Radicals / Aging / Oxidative Stress / Mitochondria / DNA damage / Free Radical / Biological Sciences / Antioxidants / Mitochondrial DNA / Humans / Mutation / Reactive Oxygen Species / Mice / Animals / CHEMICAL SCIENCES / Age Factors / Free Radical / Biological Sciences / Antioxidants / Mitochondrial DNA / Humans / Mutation / Reactive Oxygen Species / Mice / Animals / CHEMICAL SCIENCES / Age Factors

Mitokondrium, oxidatív stressz és öregedés

Free Radicals / Aging / Oxidative Stress / Mitochondria / DNA damage / Free Radical / Biological Sciences / Antioxidants / Mitochondrial DNA / Humans / Mutation / Reactive Oxygen Species / Mice / Animals / CHEMICAL SCIENCES / Age Factors / Free Radical / Biological Sciences / Antioxidants / Mitochondrial DNA / Humans / Mutation / Reactive Oxygen Species / Mice / Animals / CHEMICAL SCIENCES / Age Factors

Integrated biomarker responses as environmental status descriptors of a coastal zone (São Paulo, Brazil)

Water quality / Ecotoxicology / Biomarkers / Brazil / Environmental Monitoring / DNA damage / Multivariate Analysis / Environmental Sciences / Toxicity / Bivalvia / Animals / Biomonitoring / Catalase / Glutathione Peroxidase / Cost effectiveness / South America / Seawater / Lipid peroxidation / CHEMICAL SCIENCES / Integrated Approach / Antioxidant enzyme / Environmental quality / Coastal Zone / Biological markers / Water Quality / Biological Monitoring / Seasons / Glutathione Transferase / Environment / DNA damage / Multivariate Analysis / Environmental Sciences / Toxicity / Bivalvia / Animals / Biomonitoring / Catalase / Glutathione Peroxidase / Cost effectiveness / South America / Seawater / Lipid peroxidation / CHEMICAL SCIENCES / Integrated Approach / Antioxidant enzyme / Environmental quality / Coastal Zone / Biological markers / Water Quality / Biological Monitoring / Seasons / Glutathione Transferase / Environment

An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas

Cell Cycle / DNA damage / Apoptosis / Humans / Child / Mice / Animals / Sarcoma / Cell Proliferation / Antineoplastic Agents / Heterocyclic compounds / Mesenchymal Stromal Cells / Gene expression profiling / Mice / Animals / Sarcoma / Cell Proliferation / Antineoplastic Agents / Heterocyclic compounds / Mesenchymal Stromal Cells / Gene expression profiling

Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage

Genetic Toxicology / Flow Cytometry / Cell Cycle / Prostate Cancer / DNA damage / Apoptosis / Environmental Biotechnology / Cell Division / Cell line / Humans / Mutation / Reactive Oxygen Species / Mice / Female / Animals / Breast / Nucleosomes / nuclear DNA / Comet Assay / Phenolic compound / Rats / Stilbenes / Cell Proliferation / Tobacco Smoke / Oxidative Dna Damage / Human Fibroblasts / Oxidation-Reduction / Cell Growth / Apoptosis / Environmental Biotechnology / Cell Division / Cell line / Humans / Mutation / Reactive Oxygen Species / Mice / Female / Animals / Breast / Nucleosomes / nuclear DNA / Comet Assay / Phenolic compound / Rats / Stilbenes / Cell Proliferation / Tobacco Smoke / Oxidative Dna Damage / Human Fibroblasts / Oxidation-Reduction / Cell Growth

Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells

Flow Cytometry / DNA damage / DNA repair / Multidisciplinary / DNA / Humans / Mice / Female / Animals / Recurrence / Cisplatin / microRNAs / Cell Survival / Down-Regulation / Humans / Mice / Female / Animals / Recurrence / Cisplatin / microRNAs / Cell Survival / Down-Regulation

Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents

Confocal Microscopy / DNA damage / Multidisciplinary / RNA interference / Humans / Microarray Analysis / Neoplasms / Gene expression profiling / Immunoblotting / Microarray Analysis / Neoplasms / Gene expression profiling / Immunoblotting

Mitochondrial DNA Copy Number and Exposure to Polycyclic Aromatic Hydrocarbons

DNA damage / Mitochondrial DNA / Humans / Male / DNA methylation / Young Adult / Gene Dosage / Polycyclic aromatic hydrocarbons (PAHs) / Middle Aged / Adult / Occupational Exposure / Lymphocytes / Occupational Diseases / Coke / Young Adult / Gene Dosage / Polycyclic aromatic hydrocarbons (PAHs) / Middle Aged / Adult / Occupational Exposure / Lymphocytes / Occupational Diseases / Coke

Endosome-to-cytosol transport of viral nucleocapsids

Biochemistry / Genetics / Biophysics / Electron Microscopy / Molecular Biology / Stem Cells / Migration / MicroRNA / Cancer / Fluorescence Microscopy / Cell Cycle / Cell Biology / DNA damage / Apoptosis / Adhesion / Nature / Cytoskeleton / Signal Transduction / Transcription / Biological Sciences / Cell line / Humans / Animals / Vesicular Stomatitis Virus / Membrane Fusion / Signalling / Chromatin / Cattle / Epithelial cells / Domains / Time Factors / Viral Infection / HeLa cells / Polarity / Receptor / Zebrafish / Human Fibroblasts / Monoglycerides / Vesicle Formation / Protein Binding / Endosomes / Stem Cells / Migration / MicroRNA / Cancer / Fluorescence Microscopy / Cell Cycle / Cell Biology / DNA damage / Apoptosis / Adhesion / Nature / Cytoskeleton / Signal Transduction / Transcription / Biological Sciences / Cell line / Humans / Animals / Vesicular Stomatitis Virus / Membrane Fusion / Signalling / Chromatin / Cattle / Epithelial cells / Domains / Time Factors / Viral Infection / HeLa cells / Polarity / Receptor / Zebrafish / Human Fibroblasts / Monoglycerides / Vesicle Formation / Protein Binding / Endosomes

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

Immunology / Cancer / Gamma Rays / DNA damage / Apoptosis / Biological Sciences / Mice / Animals / Cell Death / Cdd / Differentiation / Lymphocytes / Human Fibroblasts / Whole Body / Cell Growth / Biological Sciences / Mice / Animals / Cell Death / Cdd / Differentiation / Lymphocytes / Human Fibroblasts / Whole Body / Cell Growth

Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene

Flow Cytometry / Immunohistochemistry / Enzyme Inhibitors / DNA damage / Apoptosis / Prevention / Western blotting / DNA / Male Reproduction Health / Toxicity / Reproductive toxicology / Mice / Applied / Animals / Male / Cell Death / Cytoprotection / Red Wine / Lung / tESTIS / Enzyme / Aryl Hydrocarbon Receptor / Apoptose / Public health systems and services research / Stilbenes / Reproductive / Spermatozoa / Somatic Cell Count / Sperm Count / Germ Cell / Applied Toxicology / Prevention / Western blotting / DNA / Male Reproduction Health / Toxicity / Reproductive toxicology / Mice / Applied / Animals / Male / Cell Death / Cytoprotection / Red Wine / Lung / tESTIS / Enzyme / Aryl Hydrocarbon Receptor / Apoptose / Public health systems and services research / Stilbenes / Reproductive / Spermatozoa / Somatic Cell Count / Sperm Count / Germ Cell / Applied Toxicology

Protein kinase Cη activates NF-κB in response to camptothecin-induced DNA damage

DNA damage / Humans / Adaptive Immunity / Drug Resistance / Cell Death / NF-kappa B / Transcription Factor / Cell nucleus / Camptothecin / Protein Kinase / Biochemistry and cell biology / Anticancer Drug / NF-kappa B / Transcription Factor / Cell nucleus / Camptothecin / Protein Kinase / Biochemistry and cell biology / Anticancer Drug
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