DNA damage

Integrated biomarker responses as environmental status descriptors of a coastal zone (São Paulo, Brazil)

Water quality / Ecotoxicology / Brazil / Environmental Monitoring / DNA damage / Multivariate Analysis / Environmental Sciences / Bivalvia / Animals / Catalase / Glutathione Peroxidase / Cost effectiveness / South America / Seawater / Lipid peroxidation / CHEMICAL SCIENCES / Integrated Approach / Antioxidant enzyme / Environmental quality / Coastal Zone / Biological markers / Water Quality / Seasons / Glutathione Transferase / Multivariate Analysis / Environmental Sciences / Bivalvia / Animals / Catalase / Glutathione Peroxidase / Cost effectiveness / South America / Seawater / Lipid peroxidation / CHEMICAL SCIENCES / Integrated Approach / Antioxidant enzyme / Environmental quality / Coastal Zone / Biological markers / Water Quality / Seasons / Glutathione Transferase

Akt Inhibitors as Chemosensitizers

DNA damage / Mechanism of action / Multi Drug Resistant Cancer / Growth factor receptor

Cdk1 Participates in BRCA1-Dependent S Phase Checkpoint Control in Response to DNA Damage

DNA damage / DNA repair / Signal Transduction / Cell and Molecular Biology / Biological Sciences / Cell line / Humans / Mutation / Phosphorylation / Cell Cycle Proteins / DNA binding proteins / Cell line / Humans / Mutation / Phosphorylation / Cell Cycle Proteins / DNA binding proteins

p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death

DNA damage / DNA repair / Cell Division / Humans / Blood / Cell Death / Clinical Sciences / Newborn Infant / Base Sequence / Cell Death / Clinical Sciences / Newborn Infant / Base Sequence

Genetic toxicology of a paradoxical human carcinogen, arsenic: a review

Genetics / International organizations / Arsenic / DNA damage / India / Cytogenetics / Humans / Mutation / Animals / Ground Water / Drinking Water / Animal Model / Carcinogens / Human health / Clinical Study / International Organizations / Arsenic Contamination / Mutagens / Cytogenetics / Humans / Mutation / Animals / Ground Water / Drinking Water / Animal Model / Carcinogens / Human health / Clinical Study / International Organizations / Arsenic Contamination / Mutagens

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Structural study of DNA duplex containing an N-(2-deoxy- -D-erythro-pentofuranosyl) formamide frameshift by NMR and restrained molecular dynamics

Nuclear Magnetic Resonance / Information Extraction / Magnetic Resonance Spectroscopy / DNA damage / Biological Sciences / DNA / Environmental Sciences / Temperature / Nucleic Acids / Base Sequence / Protons / Molecular Dynamic Simulation / Nucleic Acid Conformation / Molecular Structure / Ribose / DNA / Environmental Sciences / Temperature / Nucleic Acids / Base Sequence / Protons / Molecular Dynamic Simulation / Nucleic Acid Conformation / Molecular Structure / Ribose

How adeno-associated virus Rep78 protein arrests cells completely in S phase

DNA damage / Multidisciplinary / Humans / Chromatin / HeLa cells / Transfection / Cell Proliferation / Cell Cycle Proteins / DNA binding proteins / Transfection / Cell Proliferation / Cell Cycle Proteins / DNA binding proteins

High Mitochondrial Priming Sensitizes hESCs to DNA-Damage-Induced Apoptosis

Mitochondria / DNA damage / Stem Cell / Apoptosis / Biological Sciences / Humans / Embryonic Stem Cells / Humans / Embryonic Stem Cells

Apoptosis in substantia nigra following developmental striatal excitotoxic injury

Electron Microscopy / DNA damage / Apoptosis / Multidisciplinary / DNA / Female / Animals / Male / Cell Death / Substantia nigra / Neurons / Tyrosine Hydroxylase / Rats / Time Course / Substantia nigra pars compacta (SNpc) / Female / Animals / Male / Cell Death / Substantia nigra / Neurons / Tyrosine Hydroxylase / Rats / Time Course / Substantia nigra pars compacta (SNpc)

TcPARP: A DNA damage-dependent poly(ADP-ribose) polymerase from Trypanosoma cruzi

Microbiology / Parasitology / Zoology / Immunohistochemistry / DNA damage / DNA repair / Gene expression / DNA / Magnesium / Escherichia coli / Parasite / Animals / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Enzyme / Hydrogen Peroxide / Molecular cloning / Trypanosoma Cruzi / For / Metal ion / Veterinary Sciences / Base Sequence / Catalytic Activity / PARP / Immunoblotting / DNA repair / Gene expression / DNA / Magnesium / Escherichia coli / Parasite / Animals / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Enzyme / Hydrogen Peroxide / Molecular cloning / Trypanosoma Cruzi / For / Metal ion / Veterinary Sciences / Base Sequence / Catalytic Activity / PARP / Immunoblotting

Telomeres in Drag: dressing as DNA damage to engage telomerase

Genetics / DNA replication / DNA damage / Telomerase / Humans / Animals / Telomere / Animals / Telomere

Astragalin from Cassia alata Induces DNA Adducts in Vitro and Repairable DNA Damage in the Yeast Saccharomyces cerevisiae

Genetics / DNA damage / DNA repair / Vibration / Saccharomyces cerevisiae / Antioxidants / High Pressure Liquid Chromatography / Molecular sciences / Fourier transform infrared spectroscopy / Cassia / Cassia Alata / Plant Leaves / Astragalin / Antioxidants / High Pressure Liquid Chromatography / Molecular sciences / Fourier transform infrared spectroscopy / Cassia / Cassia Alata / Plant Leaves / Astragalin

DNA-PKcs and ATM co-regulate DNA double-strand break repair

Regulation / HR / Radiobiology of Ionizing Radiation / DNA damage / DNA repair / Stability / Ir / Mutation / Animals / Kinase inhibitor / Phosphorylation / Genome / Genetic Recombination / Homologous Recombination / Protein Kinase / Ionizing Radiation / Cell Cycle Proteins / DNA binding proteins / Biochemistry and cell biology / Nhej / DNA double strand breaks / Stability / Ir / Mutation / Animals / Kinase inhibitor / Phosphorylation / Genome / Genetic Recombination / Homologous Recombination / Protein Kinase / Ionizing Radiation / Cell Cycle Proteins / DNA binding proteins / Biochemistry and cell biology / Nhej / DNA double strand breaks
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