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Crystal Structure of Mycobacterium tuberculosis Catalase-Peroxidase

Thermodynamics / Molecular Biology / Protein Science / Biological Chemistry / Multidisciplinary / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Tuberculosis / Mycobacterium tuberculosis / Mutation / Circular Dichroism / Escherichia coli / Mice / Female / Animals / Fluconazole / Cell Death / Physical sciences / Drug Design / Spectrophotometry / Heme / Membrane transport proteins / Enzyme / CHEMICAL SCIENCES / Electrons / Molecular cloning / Active site / Protein Secondary Structure Prediction / Lysine / X ray diffraction / Time Factors / Antifungal Agents / Protein Conformation / Growth Inhibition / Amino Acid Sequence / Protein Binding / Hydrolysis / Cytoplasm / Ligands / Enzyme Catalysis / Protein Transport / Biochemistry and cell biology / Solvents / Dimerization / Adenosine Triphosphate / Adenosine Diphosphate / Molecular Sequence Data / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Tuberculosis / Mycobacterium tuberculosis / Mutation / Circular Dichroism / Escherichia coli / Mice / Female / Animals / Fluconazole / Cell Death / Physical sciences / Drug Design / Spectrophotometry / Heme / Membrane transport proteins / Enzyme / CHEMICAL SCIENCES / Electrons / Molecular cloning / Active site / Protein Secondary Structure Prediction / Lysine / X ray diffraction / Time Factors / Antifungal Agents / Protein Conformation / Growth Inhibition / Amino Acid Sequence / Protein Binding / Hydrolysis / Cytoplasm / Ligands / Enzyme Catalysis / Protein Transport / Biochemistry and cell biology / Solvents / Dimerization / Adenosine Triphosphate / Adenosine Diphosphate / Molecular Sequence Data

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sedução subliminar

Synchrotron Radiation / Macromolecular X-Ray Crystallography / Crystal structure / Humans / Ligand Binding / Drug Design / Biochemical / Enzyme / Protein Conformation / Recombinant Proteins / Adenosine Deaminase / Ligands / Binding Site / Purine nucleoside phosphorylase (PNP) / Nucleotides / Biochemistry and cell biology / Purine Nucleoside Phosphorylase / Drug Design / Biochemical / Enzyme / Protein Conformation / Recombinant Proteins / Adenosine Deaminase / Ligands / Binding Site / Purine nucleoside phosphorylase (PNP) / Nucleotides / Biochemistry and cell biology / Purine Nucleoside Phosphorylase

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Developing a Drug-like Natural Product Library

Natural Products / Drug development / Biological Sciences / Natural Product / Drug Design / Lead Generation / CHEMICAL SCIENCES / Natural / Active Ingredient / Pharmaceutical preparations / Lead Generation / CHEMICAL SCIENCES / Natural / Active Ingredient / Pharmaceutical preparations

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Developing a Drug-like Natural Product Library

Natural Products / Drug development / Biological Sciences / Natural Product / Drug Design / Lead Generation / CHEMICAL SCIENCES / Natural / Active Ingredient / Pharmaceutical preparations / Lead Generation / CHEMICAL SCIENCES / Natural / Active Ingredient / Pharmaceutical preparations

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CNS Drug Delivery Systems: Novel Approaches

Pharmaceutical Technology / Drug delivery / Drug development / Drug Delivery System / Cerebrospinal Fluid / Brain / Humans / Cerebrovascular Disease / United States / Blood brain barrier / Drug Design / Central Nervous System / Drug Delivery Systems / Heart Disease / Drug Targeting / Trigeminal / Brain Tumour / Pharmaceutical preparations / Brain / Humans / Cerebrovascular Disease / United States / Blood brain barrier / Drug Design / Central Nervous System / Drug Delivery Systems / Heart Disease / Drug Targeting / Trigeminal / Brain Tumour / Pharmaceutical preparations

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Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target

Structure / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Tuberculosis / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data

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Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target

Structure / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Tuberculosis / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data

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Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis

Computational Biology / Kinetics / Enzyme Inhibitors / Multidisciplinary / Antibiotic Resistance / Crystal structure / Tuberculosis / Mycobacterium tuberculosis / Escherichia coli / Drug Design / Active site / Substrate Specificity / Fatty Acid / National Cancer Institute / University of Southern California / Cell Wall / In Silico / Protein Quaternary Structure / Ligands / Crystal structure / Tuberculosis / Mycobacterium tuberculosis / Escherichia coli / Drug Design / Active site / Substrate Specificity / Fatty Acid / National Cancer Institute / University of Southern California / Cell Wall / In Silico / Protein Quaternary Structure / Ligands

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Developing a Drug-like Natural Product Library

Natural Products / Drug development / Biological Sciences / Natural Product / Drug Design / Lead Generation / CHEMICAL SCIENCES / Natural / Active Ingredient / Pharmaceutical preparations / Lead Generation / CHEMICAL SCIENCES / Natural / Active Ingredient / Pharmaceutical preparations

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Synthesis of 13-amino costunolide derivatives as anticancer agents

Organic Chemistry / Pharmaceutical Chemistry / Cell line / Humans / Mice / Animals / Drug Design / Sesquiterpenes / Bioorganic and medicinal Chemistry / Indexation / Antineoplastic Agents / Animals / Drug Design / Sesquiterpenes / Bioorganic and medicinal Chemistry / Indexation / Antineoplastic Agents

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CNS Drug Delivery Systems: Novel Approaches

Pharmaceutical Technology / Drug delivery / Drug development / Drug Delivery System / Cerebrospinal Fluid / Brain / Humans / Cerebrovascular Disease / United States / Blood brain barrier / Drug Design / Central Nervous System / Drug Delivery Systems / Heart Disease / Drug Targeting / Trigeminal / Brain Tumour / Pharmaceutical preparations / Brain / Humans / Cerebrovascular Disease / United States / Blood brain barrier / Drug Design / Central Nervous System / Drug Delivery Systems / Heart Disease / Drug Targeting / Trigeminal / Brain Tumour / Pharmaceutical preparations

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Structural genomics: a new era for pharmaceutical research

Genomics / Computational Biology / Research / Structural Genomics / Biological Sciences / Environmental Sciences / Humans / Drug Design / Genome / Proteins / Protein Secondary Structure Prediction / Drug Industry / Environmental Sciences / Humans / Drug Design / Genome / Proteins / Protein Secondary Structure Prediction / Drug Industry

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Amphiphilic NO-Donor Antioxidants

Organic Chemistry / Phospholipids / NMR Spectroscopy / Magnetic Resonance Spectroscopy / Antioxidants / Animals / Male / Drug Design / Rats / Surface Active Agents / Wistar Rats / Quaternary Ammonium Compounds / Structure activity Relationship / Vasodilation / Oxidation-Reduction / Amphiphiles / Nitric oxide donors / Animals / Male / Drug Design / Rats / Surface Active Agents / Wistar Rats / Quaternary Ammonium Compounds / Structure activity Relationship / Vasodilation / Oxidation-Reduction / Amphiphiles / Nitric oxide donors

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Synthesis of 13-amino costunolide derivatives as anticancer agents

Organic Chemistry / Pharmaceutical Chemistry / Cell line / Humans / Mice / Animals / Drug Design / Sesquiterpenes / Bioorganic and medicinal Chemistry / Indexation / Antineoplastic Agents / Animals / Drug Design / Sesquiterpenes / Bioorganic and medicinal Chemistry / Indexation / Antineoplastic Agents

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Natural Occurring Polyphenols as Template for Drug Design. Focus on Serine Proteases

Flavonoids / Polyphenols / Drug Design / Phenols / Structure activity Relationship / Serine Protease / Biochemistry and cell biology / Serine Protease / Biochemistry and cell biology

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Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase

Organic Chemistry / Enzyme Inhibitors / Humans / Mice / Blood Pressure / Animals / Male / Drug Design / Solubility / Time Factors / Functional Group / Bioorganic and medicinal Chemistry / Structure activity Relationship / Adamantane / Physical Properties / Molecular Structure / Animals / Male / Drug Design / Solubility / Time Factors / Functional Group / Bioorganic and medicinal Chemistry / Structure activity Relationship / Adamantane / Physical Properties / Molecular Structure

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