Drug Design

Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase–dihydrofolate reductase

Organic Chemistry / Enzyme Inhibitors / Drug Design / Multienzyme complexes / Cryptosporidium / Structure activity Relationship / Molecular Structure / Structure activity Relationship / Molecular Structure

The Drug Discovery Portal: a resource to enhance drug discovery from academia

Research Design / Drug Discovery / Pharmaceutical Chemistry / Scotland / Drug Design / Drug Delivery Systems / Universities / Drug Industry / Cooperative Behavior / Drug Delivery Systems / Universities / Drug Industry / Cooperative Behavior

UDP-Glucuronosyltransferase inhibitors

Enzyme Inhibitors / Humans / Pesticides / Drug Design / Detoxification

GAMESS As a Free Quantum-Mechanical Platform for Drug Research

Computational Biology / Quantum Theory / Drug Discovery / Software / Drug Design / Protein Binding / Ligands / Protein Binding / Ligands

Disulfide-rich macrocyclic peptides as templates in drug design

Organic Chemistry / Drug Design / Cyclic peptides / Molecular Conformation

Cyclotides as a basis for drug design

Communicable Diseases / Humans / Animals / Drug Design / Peptides / Cyclotides / Neoplasms / Cardiovascular Diseases / Drug Stability / Cyclotides / Neoplasms / Cardiovascular Diseases / Drug Stability

Conserved Fungal Genes as Potential Targets for Broad-Spectrum Antifungal Drug Discovery

Computational Biology / Drug Discovery / Biological Sciences / Drug Design / Candida albicans / Spectrum / Antifungal Agents / Microbial Sensitivity Tests / Base Sequence / Eukaryotic Cell / Spectrum / Antifungal Agents / Microbial Sensitivity Tests / Base Sequence / Eukaryotic Cell

Nucleolipids as Potential Organogelators

Water / Lipids / Drug Design / HYDROCARBONS / Gels / Nucleosides / Biochemistry and cell biology / Acyclovir / Solvents / Nucleosides / Biochemistry and cell biology / Acyclovir / Solvents

Nucleolipids as Potential Organogelators

Water / Lipids / Drug Design / HYDROCARBONS / Gels / Nucleosides / Biochemistry and cell biology / Acyclovir / Solvents / Nucleosides / Biochemistry and cell biology / Acyclovir / Solvents

Computer-assisted design for paracetamol masking bitter taste prodrugs

Thermodynamics / Computer Aided Design / Molecular modeling / DFT calculation / Electron Transfer / Drug Design / Proton Transfer / Taste / Enzyme / Hydrogen Bond / Hydrogen Bonding / THEORETICAL AND COMPUTATIONAL CHEMISTRY / Acetaminophen / Computer-assisted instructional design / Reaction Rate / Kinetic Parameter / Drug Design / Proton Transfer / Taste / Enzyme / Hydrogen Bond / Hydrogen Bonding / THEORETICAL AND COMPUTATIONAL CHEMISTRY / Acetaminophen / Computer-assisted instructional design / Reaction Rate / Kinetic Parameter

Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria

Gene Silencing / Humans / Animals / Drug Design / Biochemical / Protease Inhibitors / Plasmodium falciparum / Antimalarials / Protein Conformation / Amino Acid Sequence / Erythrocytes / Drug Targeting / Carbamates / Biochemistry and cell biology / Protease Inhibitors / Plasmodium falciparum / Antimalarials / Protein Conformation / Amino Acid Sequence / Erythrocytes / Drug Targeting / Carbamates / Biochemistry and cell biology

N-1H-Benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists

Organic Chemistry / Drug metabolism / Nuclear Receptor / Cell line / Humans / Drug Design / Enzyme / Bioorganic and medicinal Chemistry / Primary Culture / Benzimidazoles / Human Disease / Structure activity Relationship / Chemical Modification / Molecular Structure / Gene Expression Regulation / Pregnane X Receptor / Drug Design / Enzyme / Bioorganic and medicinal Chemistry / Primary Culture / Benzimidazoles / Human Disease / Structure activity Relationship / Chemical Modification / Molecular Structure / Gene Expression Regulation / Pregnane X Receptor

GPR119 as a fat sensor

Biological Sciences / Humans / Mice / G protein-coupled receptors / Animals / Drug Design / Oral Hypoglycemic Agents / Type 2 Diabetes Mellitus / Trends In Pharmacological Sciences / Molecular Targeted Therapy / Drug Design / Oral Hypoglycemic Agents / Type 2 Diabetes Mellitus / Trends In Pharmacological Sciences / Molecular Targeted Therapy

Phenylacetic acid derivatives as hPPAR agonists

Organic Chemistry / Transcription Factors / Insulin Resistance / Blood Glucose / Mice / Animals / Male / Drug Design / Triglycerides / Rats / Oral Hypoglycemic Agents / Bioorganic and medicinal Chemistry / Thiazoles / Animals / Male / Drug Design / Triglycerides / Rats / Oral Hypoglycemic Agents / Bioorganic and medicinal Chemistry / Thiazoles

Gastroprotective effect of Monolluma quadrangula

Drug development / Drug Design / Catalase / Superoxide Dismutase / Gastric Ulcer / HSP70 / Malondialdehyde / HSP70 / Malondialdehyde

The TB Structural Genomics Consortium: A decade of progress

Genomics / International Cooperation / Structural Genomics / Macromolecular X-Ray Crystallography / Tuberculosis / Humans / Mycobacterium tuberculosis / Magnetic Resonance / Drug Design / Protein Interaction / Humans / Mycobacterium tuberculosis / Magnetic Resonance / Drug Design / Protein Interaction

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