Drug Targeting | DADOSPDF

CNS Drug Delivery Systems: Novel Approaches

Pharmaceutical Technology / Drug delivery / Drug development / Drug Delivery System / Cerebrospinal Fluid / Brain / Humans / Cerebrovascular Disease / United States / Blood brain barrier / Drug Design / Central Nervous System / Drug Delivery Systems / Heart Disease / Drug Targeting / Trigeminal / Brain Tumour / Pharmaceutical preparations / Brain / Humans / Cerebrovascular Disease / United States / Blood brain barrier / Drug Design / Central Nervous System / Drug Delivery Systems / Heart Disease / Drug Targeting / Trigeminal / Brain Tumour / Pharmaceutical preparations

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Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target

Structure / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Tuberculosis / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data

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Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target

Structure / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Tuberculosis / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data / Humans / Mycobacterium tuberculosis / Drug Design / Enzyme / CHEMICAL SCIENCES / Mode of action / Active site / Substrate Specificity / Convergent Evolution / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Drug Targeting / Binding Site / Conformational Change / Molecular Sequence Data

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CNS Drug Delivery Systems: Novel Approaches

Pharmaceutical Technology / Drug delivery / Drug development / Drug Delivery System / Cerebrospinal Fluid / Brain / Humans / Cerebrovascular Disease / United States / Blood brain barrier / Drug Design / Central Nervous System / Drug Delivery Systems / Heart Disease / Drug Targeting / Trigeminal / Brain Tumour / Pharmaceutical preparations / Brain / Humans / Cerebrovascular Disease / United States / Blood brain barrier / Drug Design / Central Nervous System / Drug Delivery Systems / Heart Disease / Drug Targeting / Trigeminal / Brain Tumour / Pharmaceutical preparations

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Toxoplasma gondii aspartic protease 1 is not essential in tachyzoites

Microbiology / Toxoplasma / Toxoplasma gondii / Experimental parasitology / Cercopithecus aethiops / Humans / Secretory Pathway / Animals / Virulence factor / Veterinary Sciences / Drug Targeting / Vero cells / Humans / Secretory Pathway / Animals / Virulence factor / Veterinary Sciences / Drug Targeting / Vero cells

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CNS Drug Delivery Systems: Novel Approaches

Pharmaceutical Technology / Drug delivery / Drug development / Drug Delivery System / Cerebrospinal Fluid / Brain / Humans / Cerebrovascular Disease / United States / Blood brain barrier / Drug Design / Central Nervous System / Drug Delivery Systems / Heart Disease / Drug Targeting / Trigeminal / Brain Tumour / Pharmaceutical preparations / Brain / Humans / Cerebrovascular Disease / United States / Blood brain barrier / Drug Design / Central Nervous System / Drug Delivery Systems / Heart Disease / Drug Targeting / Trigeminal / Brain Tumour / Pharmaceutical preparations

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Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

Organic Chemistry / Kinetics / Modeling / Crystallization / Enzyme Inhibitors / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Crystal structure / In Vitro / Virtual screening / Animals / Ligand Binding / Drug Design / Molecular docking / Glycoproteins / Chagas disease / Enzyme / Neuraminidase / Active site / Trypanosoma Cruzi / Ether / Molecular Model / Bioorganic and medicinal Chemistry / Sialic Acid / In Silico / Drug Targeting / Ligands / Trans-Sialidase / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Crystal structure / In Vitro / Virtual screening / Animals / Ligand Binding / Drug Design / Molecular docking / Glycoproteins / Chagas disease / Enzyme / Neuraminidase / Active site / Trypanosoma Cruzi / Ether / Molecular Model / Bioorganic and medicinal Chemistry / Sialic Acid / In Silico / Drug Targeting / Ligands / Trans-Sialidase

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Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria

Fluorescence Microscopy / Gene Silencing / Humans / Germ Cells / Animals / Drug Design / Endoplasmic Reticulum / ER stress / Biochemical / Protease Inhibitors / Presenilins / Plasmodium falciparum / Antimalarials / Heat Shock Proteins / Protein Conformation / Amino Acid Sequence / Erythrocytes / Drug Targeting / GFP / Carbamates / Biochemistry and cell biology / Drug Design / Endoplasmic Reticulum / ER stress / Biochemical / Protease Inhibitors / Presenilins / Plasmodium falciparum / Antimalarials / Heat Shock Proteins / Protein Conformation / Amino Acid Sequence / Erythrocytes / Drug Targeting / GFP / Carbamates / Biochemistry and cell biology

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CNS Drug Delivery Systems: Novel Approaches

Pharmaceutical Technology / Drug delivery / Drug development / Drug Delivery System / Cerebrospinal Fluid / Brain / Humans / Cerebrovascular Disease / United States / Blood brain barrier / Drug Design / Central Nervous System / Drug Delivery Systems / Heart Disease / Drug Targeting / Trigeminal / Brain Tumour / Pharmaceutical preparations / Brain / Humans / Cerebrovascular Disease / United States / Blood brain barrier / Drug Design / Central Nervous System / Drug Delivery Systems / Heart Disease / Drug Targeting / Trigeminal / Brain Tumour / Pharmaceutical preparations

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Mycobacterium tuberculosis transporter MmpL7 is a potential substrate for kinase PknD

Mass Spectrometry / Virulence / Tuberculosis / Mycobacterium tuberculosis / Protein Kinases / Phosphorylation / Biochemical / Membrane transport proteins / Substrate Specificity / Virulence factor / Protein Kinase / Amino Acid Sequence / Cell Wall / Protein Binding / Drug Targeting / Biochemistry and cell biology / Phosphorylation / Biochemical / Membrane transport proteins / Substrate Specificity / Virulence factor / Protein Kinase / Amino Acid Sequence / Cell Wall / Protein Binding / Drug Targeting / Biochemistry and cell biology

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Albumin-based nanoparticles as potential controlled release drug delivery systems

Biomedical Engineering / Self Assembly / Drug delivery / Nanoparticles / Drug Delivery System / Humans / Controlled release / Surface modification / Animals / Surface Properties / Side Effect / Spray Drying / Drug Targeting / Drug Carriers / Delayed-Action Preparations / Humans / Controlled release / Surface modification / Animals / Surface Properties / Side Effect / Spray Drying / Drug Targeting / Drug Carriers / Delayed-Action Preparations

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A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development

Flow Cytometry / Fluorescence Microscopy / Cell Cycle / Multidisciplinary / Western blotting / Phylogeny / Humans / Animals / Genes / Calpain / Plasmodium falciparum / Gene Disruption / Drug Targeting / Fusion Protein / Phylogeny / Humans / Animals / Genes / Calpain / Plasmodium falciparum / Gene Disruption / Drug Targeting / Fusion Protein

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Confronting parasites from Canada

Genetics / Leishmania / Biological Sciences / Canada / Humans / TRENDS / Animals / Drug Resistance / Parasites / Fasciola hepatica / Interleukins / Entamoeba histolytica / Parasitic Diseases / Anthelmintics / Drug Targeting / Helminthiasis / Gene Expression Regulation / TRENDS / Animals / Drug Resistance / Parasites / Fasciola hepatica / Interleukins / Entamoeba histolytica / Parasitic Diseases / Anthelmintics / Drug Targeting / Helminthiasis / Gene Expression Regulation

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Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malaria

Gene Silencing / Humans / Animals / Drug Design / Biochemical / Protease Inhibitors / Plasmodium falciparum / Antimalarials / Protein Conformation / Amino Acid Sequence / Erythrocytes / Drug Targeting / Carbamates / Biochemistry and cell biology / Protease Inhibitors / Plasmodium falciparum / Antimalarials / Protein Conformation / Amino Acid Sequence / Erythrocytes / Drug Targeting / Carbamates / Biochemistry and cell biology

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Confronting parasites from Canada

Genetics / Leishmania / Biological Sciences / Canada / Humans / TRENDS / Animals / Drug Resistance / Parasites / Fasciola hepatica / Interleukins / Entamoeba histolytica / Parasitic Diseases / Anthelmintics / Drug Targeting / Helminthiasis / Gene Expression Regulation / Host Defense / TRENDS / Animals / Drug Resistance / Parasites / Fasciola hepatica / Interleukins / Entamoeba histolytica / Parasitic Diseases / Anthelmintics / Drug Targeting / Helminthiasis / Gene Expression Regulation / Host Defense

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Mycobacterial ATP synthase as drug target

ATP synthase / Drug Targeting / Biochemistry and cell biology

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