Drug development

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

Drug development / Multidisciplinary / Macromolecular X-Ray Crystallography / Mice / Animals / Drug Resistance / Drug Design / Plasmodium falciparum / Antimalarials / Protein Conformation / Molecular Structure / Drug Resistance / Drug Design / Plasmodium falciparum / Antimalarials / Protein Conformation / Molecular Structure

Pseudo-peptides derived from isomannide: inhibitors of serine proteases

Drug development / Hepatitis C / Humans / Drug Design / Enzyme / Amino Acids / Hepatocytes / Serine Protease / Cell Survival / Benzamides / Antiviral Agents / West Nile / Amino Acids / Hepatocytes / Serine Protease / Cell Survival / Benzamides / Antiviral Agents / West Nile

Drug development from marine natural products

Marine Biology / Clinical Trial / European Union / Drug Discovery / Drug development / Biological Sciences / Humans / United States / Animals / Neoplasms / Antineoplastic Agents / Anticancer Drug / Marine Natural Product / Biological Sciences / Humans / United States / Animals / Neoplasms / Antineoplastic Agents / Anticancer Drug / Marine Natural Product

Genomic aspects of sporadic Parkinson\'s disease

Cognitive Science / Molecular Biology / Genomics / Drug development / Gene expression / Neuronal cell death / Humans / Substantia nigra / Clinical Sciences / Parkinson Disease / Glutamate Receptor / Neuronal cell death / Humans / Substantia nigra / Clinical Sciences / Parkinson Disease / Glutamate Receptor

Tripartite siRNA micelles as controlled delivery systems for primary dendritic cells

Immune response / Drug development / Gene Silencing / Dendritic Cells / Transgenic Mice / Block Copolymer / RNA interference / Micelles / Mice / Endocytosis / Animals / Dendritic cell / Delivery System / Hydrogen-Ion Concentration / Block Copolymer / RNA interference / Micelles / Mice / Endocytosis / Animals / Dendritic cell / Delivery System / Hydrogen-Ion Concentration

A new inhibitor for fructosamine 3-kinase (Amadorase)

Drug development

Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi

Organic Chemistry / Drug development / Macromolecular X-Ray Crystallography / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Molecular Structure / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Molecular Structure

Integrating systems approaches into pharmaceutical sciences

Genomics / Systems Biology / Clinical Pharmacology / Drug development / System Biology / Pharmaceutical Chemistry / Modelling and simulation / Computer Simulation / Europe / Drug Industry / Pharmaceutical Chemistry / Modelling and simulation / Computer Simulation / Europe / Drug Industry

Gastroprotective effect of Monolluma quadrangula

Drug development / Drug Design / Catalase / Superoxide Dismutase / Gastric Ulcer / HSP70 / Malondialdehyde / HSP70 / Malondialdehyde

Tripartite siRNA micelles as controlled delivery systems for primary dendritic cells

Immune response / Drug development / Gene Silencing / Dendritic Cells / Transgenic Mice / Block Copolymer / RNA interference / Micelles / Mice / Endocytosis / Animals / Dendritic cell / Delivery System / Hydrogen-Ion Concentration / Block Copolymer / RNA interference / Micelles / Mice / Endocytosis / Animals / Dendritic cell / Delivery System / Hydrogen-Ion Concentration

A systems biology view of cancer

Gene regulation / Systems Biology / Breast Cancer / Drug development / System Biology / Apoptosis / Colorectal cancer / Signal Transduction / Biological Sciences / Humans / Computer Model / Case Study / Animals / Complex network / Physical sciences / Mathematical Model / Oncogenes / Neoplasms / Diffuse Large B-Cell Lymphoma / Feedback loop / Apoptosis / Colorectal cancer / Signal Transduction / Biological Sciences / Humans / Computer Model / Case Study / Animals / Complex network / Physical sciences / Mathematical Model / Oncogenes / Neoplasms / Diffuse Large B-Cell Lymphoma / Feedback loop

Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi

Organic Chemistry / Treatment / Drug development / Macromolecular X-Ray Crystallography / In Vitro / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure

Hedgehog–Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer

Stem Cells / Drug development / Stem Cell / Transcription Factors / Signal Transduction / Brain Tumor / Brain / Humans / Cerebral Cortex / Model System / Embryos / Brain Neoplasms / Brain Tumor / Brain / Humans / Cerebral Cortex / Model System / Embryos / Brain Neoplasms

Efeitos extrapiramidais como conseqüência de tratamento com neurolépticos

Primary Care / Drug development / Drug Therapy / Verbal Memory / Side Effect / Medical Records / Therapeutic Use / Medical Records / Therapeutic Use

Extrapyramidal side effects as a consequence of treatment with neuroleptics Efeitos extrapiramidais como conseqüência de tratamento com neurolépticos

Primary Care / Drug development / Einstein / Drug Therapy / Verbal Memory / Side Effect / Medical Records / Therapeutic Use / Side Effect / Medical Records / Therapeutic Use

The soft coral Sinularia flexibilis:potential for drug development

Drug development / Applied Sport and Exercise Psychology

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