Enzyme Inhibitors

Rho GTPase Cdc42 is essential for human T-cell development

Hematology / Flow Cytometry / Enzyme Inhibitors / Stem Cell / Gene expression / Western blotting / Signal Transduction / Humans / Child / T cell development / Cell Polarity / T lymphocytes / Cell Proliferation / Rho GTPase / Western blotting / Signal Transduction / Humans / Child / T cell development / Cell Polarity / T lymphocytes / Cell Proliferation / Rho GTPase

Delta Sleep Response to Metyrapone in Post-Traumatic Stress Disorder

Stress / Neuropsychopharmacology / Electroencephalography / Enzyme Inhibitors / Post traumatic stress disorder / Cortisol / Humans / Male / Veterans / Sleep / Electromyography / Polysomnography / Middle Aged / Repeated Measures / Adult / Adrenocorticotropic Hormone / Indexation / Biological activity / Delta Rhythm / Case Control Studies / Cortisol / Humans / Male / Veterans / Sleep / Electromyography / Polysomnography / Middle Aged / Repeated Measures / Adult / Adrenocorticotropic Hormone / Indexation / Biological activity / Delta Rhythm / Case Control Studies

Novel copper amine oxidase activity from rat liver mitochondria matrix

Biochemistry / Biophysics / Enzyme Inhibitors / Transmission Electron Microscopy / Enzyme Kinetics / Dopamine / Copper / Animals / Enzyme Inhibition / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Affinity chromatography / Enzyme / Hydrogen Peroxide / Rats / Substrate Specificity / Enzyme activity / Enzymatic Activity / Biochemistry and cell biology / Dopamine / Copper / Animals / Enzyme Inhibition / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Affinity chromatography / Enzyme / Hydrogen Peroxide / Rats / Substrate Specificity / Enzyme activity / Enzymatic Activity / Biochemistry and cell biology

Amino-caprolactam derivatives as γ-secretase inhibitors

Organic Chemistry / Enzyme Inhibitors / Bioorganic and medicinal Chemistry / Caprolactam

Medicinal Chemistry of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors

Organic Chemistry / Medicinal Chemistry / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Humans / Structure activity Relationship

Na-K-ATPase inhibitor dissociated from hypertension-associated plasma protein

Mass Spectrometry / Enzyme Inhibitors / Humans / Hypertension / Animals / Male / American / Potassium / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Vasoconstriction / Enzyme / Clinical Sciences / Tritium / Molecular weight / Mass Spectroscopy / Rabbits / Digoxin / Binding Site / Low molecular weight / Blood Proteins / Radioimmunoassay / Ouabain / Male / American / Potassium / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Vasoconstriction / Enzyme / Clinical Sciences / Tritium / Molecular weight / Mass Spectroscopy / Rabbits / Digoxin / Binding Site / Low molecular weight / Blood Proteins / Radioimmunoassay / Ouabain

Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors

Organic Chemistry / Enzyme Inhibitors / Mitochondria / Mice / Animals / Drug Design / European / Pyrazoles / Structure activity Relationship / Molecular Structure / Drug Design / European / Pyrazoles / Structure activity Relationship / Molecular Structure

Kynurenamines as Neural Nitric Oxide Synthase Inhibitors

Organic Chemistry / Medicinal Chemistry / Enzyme Inhibitors / Animals / Rats / Medicinal / Molecular Conformation / Medicinal / Molecular Conformation

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

Enzyme Inhibitors / DNA damage / Multidisciplinary / Nature / Cell line / Mice / Animals / NF-kappa B / B Lymphocytes / Cell Cycle Proteins / Cell Survival / DNA binding proteins / Gene expression profiling / Mice / Animals / NF-kappa B / B Lymphocytes / Cell Cycle Proteins / Cell Survival / DNA binding proteins / Gene expression profiling

Rapid Parallel Synthesis of Dipeptide Diphenyl Phosphonate Esters as Inhibitors of Dipeptidyl Peptidases

Organic Chemistry / Enzyme Inhibitors / Combinatorial Chemistry / Proline / Glycine / Alanine / Esters / Molecular Structure / Alanine / Esters / Molecular Structure

Rapid Parallel Synthesis of Dipeptide Diphenyl Phosphonate Esters as Inhibitors of Dipeptidyl Peptidases

Organic Chemistry / Enzyme Inhibitors / Combinatorial Chemistry / Proline / Glycine / Alanine / Esters / Molecular Structure / Alanine / Esters / Molecular Structure

MAC inhibitors suppress mitochondrial apoptosis

Enzyme Inhibitors / Mitochondria / Apoptosis / Ion Channels / Biological Sciences / Cell line / Mice / Animals / Biochemical / CHEMICAL SCIENCES / Staurosporine / Recombinant Proteins / Interleukin / Cell line / Mice / Animals / Biochemical / CHEMICAL SCIENCES / Staurosporine / Recombinant Proteins / Interleukin

Phosphoramidate Dinucleosides as Hepatitis C Virus Polymerase Inhibitors

Organic Chemistry / Medicinal Chemistry / Enzyme Inhibitors / Magnetic Resonance Spectroscopy / Humans / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Nucleosides / Oxidation-Reduction / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Nucleosides / Oxidation-Reduction

Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase–dihydrofolate reductase

Organic Chemistry / Enzyme Inhibitors / Drug Design / Multienzyme complexes / Cryptosporidium / Structure activity Relationship / Molecular Structure / Structure activity Relationship / Molecular Structure

O exercício físico atenua o déficit autonômico cardíaco induzido pelo bloqueio da síntese do óxido nítrico

Enzyme Inhibitors / Autonomic Nervous System / Hypertension / Blood Pressure / Animals / Male / Heart rate / Rats / Nitric Oxide Synthase / Analysis of Variance / Wistar Rats / Propranolol / Arquivos brasileiros / Male / Heart rate / Rats / Nitric Oxide Synthase / Analysis of Variance / Wistar Rats / Propranolol / Arquivos brasileiros

Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide

Physiology / Enzyme Inhibitors / Oxidative Stress / Macrophages / Dopamine / Mice / Nitric oxide / Animals / Corticosterone / Substantia nigra / Medical Physiology / Neurons / Lysine / Nitric Oxide Synthase / Biochemistry and cell biology / Mice / Nitric oxide / Animals / Corticosterone / Substantia nigra / Medical Physiology / Neurons / Lysine / Nitric Oxide Synthase / Biochemistry and cell biology
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