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In Vitro
In Vitro
Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors
Organic Chemistry / Cancer / Levels of selection / Signal Transduction / Cell line / In Vitro / Humans / Amines / Caspase / Akt / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Selectivity / Piperidines / In Vitro / Humans / Amines / Caspase / Akt / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Selectivity / Piperidines
Síntese e avaliação da atividade antimicrobiana de novas 4-tiazolidinonas obtidas a partir de formilpiridina tiossemicarbazonas
In Vitro / CHEMICAL SCIENCES / Chemical Structure / Quimica Nova
Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability
Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure
Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability
Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure
Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability
Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure
Síntese e avaliação da atividade antimicrobiana de novas 4-tiazolidinonas obtidas a partir de formilpiridina tiossemicarbazonas
In Vitro / CHEMICAL SCIENCES / Chemical Structure / Quimica Nova
Self-Assembling Cannabinomimetics: Supramolecular Structures of N -Alkyl Amides
Natural Products / Modeling / Self Assembly / Pharmacognosy / Medicinal Plants / Biological Sciences / Micelle / In Vitro / Humans / Endocannabinoid System / CHEMICAL SCIENCES / Amides / Natural / Endocannabinoids / Monte Carlo Method / Echinacea / Molecular Structure / Biological Sciences / Micelle / In Vitro / Humans / Endocannabinoid System / CHEMICAL SCIENCES / Amides / Natural / Endocannabinoids / Monte Carlo Method / Echinacea / Molecular Structure
ANÁLISE DA VIABILIDADE CELULAR DE CALOS DE GENGIBRE ORNAMENTAL ANALYSIS OF THE CELLULAR VIABILITY OF ORNAMENTAL GINGER CALLUS
In Vitro / Tropical Plants / Tropical Flowers
ASPECTOS DA ANATOMIA E DO ÓLEO ESSENCIAL EM FOLHAS DE PINDAÍBA (Xylopia brasiliensis Spreng.) 1 Aspects of the anatomy and essential oil in leaves of pindaíba (Xylopia brasiliensis Spreng
In Vitro / Plant in Vitro Culture
Inducao analises morfologicas maracujazeiro
In Vitro / Plant in Vitro Culture
Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi
Organic Chemistry / Treatment / Drug development / Macromolecular X-Ray Crystallography / In Vitro / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure
Phosphoramidate Dinucleosides as Hepatitis C Virus Polymerase Inhibitors
Organic Chemistry / Medicinal Chemistry / Modeling / Enzyme Inhibitors / Magnetic Resonance Spectroscopy / In Vitro / Humans / Virus / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Molecular Model / Nucleosides / Chemical Synthesis / Oxidation-Reduction / In Vitro / Humans / Virus / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Molecular Model / Nucleosides / Chemical Synthesis / Oxidation-Reduction
Phosphoramidate Dinucleosides as Hepatitis C Virus Polymerase Inhibitors
Organic Chemistry / Medicinal Chemistry / Modeling / Enzyme Inhibitors / Magnetic Resonance Spectroscopy / In Vitro / Humans / Virus / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Molecular Model / Nucleosides / Chemical Synthesis / Oxidation-Reduction / In Vitro / Humans / Virus / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Molecular Model / Nucleosides / Chemical Synthesis / Oxidation-Reduction
In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytes
Rheumatology / Immunology / Stem Cell / Gene expression / In Vitro / Cell Differentiation / Humans / Collagen / Mesenchymal Stem Cell / Arthritis / Clinical Sciences / Public health systems and services research / Guided Tissue Regeneration / Articular Cartilage Wear / Chondrocytes / Transforming Growth Factor Beta / Biological markers / Chondrogenesis / Cell Proliferation / Mesenchymal Stromal Cells / Extracellular Matrix Proteins / Cell Adhesion Molecules / Cell Differentiation / Humans / Collagen / Mesenchymal Stem Cell / Arthritis / Clinical Sciences / Public health systems and services research / Guided Tissue Regeneration / Articular Cartilage Wear / Chondrocytes / Transforming Growth Factor Beta / Biological markers / Chondrogenesis / Cell Proliferation / Mesenchymal Stromal Cells / Extracellular Matrix Proteins / Cell Adhesion Molecules
Antimycobacterial Eudesmanolides from Inula helenium and Rudbeckia subtomentosa
Complementary and Alternative Medicine / Plant Biology / Pharmacognosy / Magnetic Resonance Spectroscopy / Structural Analysis / In Vitro / Mycobacterium tuberculosis / Sesquiterpenes / Qualitative Analysis / Isolation / Microbial Sensitivity Tests / Biological activity / Structure activity Relationship / Planta / Molecular Structure / In Vitro / Mycobacterium tuberculosis / Sesquiterpenes / Qualitative Analysis / Isolation / Microbial Sensitivity Tests / Biological activity / Structure activity Relationship / Planta / Molecular Structure
Trypanocidal Withanolides and Withanolide Glycosides from Dunalia brachyacantha
Natural Products / Mass Spectrometry / Bolivia / Pharmacognosy / Medicinal Plants / Leishmania / Magnetic Resonance Spectroscopy / Structural Analysis / Biological Sciences / In Vitro / ROOT / Animals / Bacteria / Withanolides / Plant Roots / CHEMICAL SCIENCES / Isolation / Trypanosoma Cruzi / Natural / Solanaceae / Microbial Sensitivity Tests / Trypanocidal Agents / Biological activity / Disaccharides / Ergosterol / Lactones / Glycosides / Plant Leaves / Leishmania / Magnetic Resonance Spectroscopy / Structural Analysis / Biological Sciences / In Vitro / ROOT / Animals / Bacteria / Withanolides / Plant Roots / CHEMICAL SCIENCES / Isolation / Trypanosoma Cruzi / Natural / Solanaceae / Microbial Sensitivity Tests / Trypanocidal Agents / Biological activity / Disaccharides / Ergosterol / Lactones / Glycosides / Plant Leaves
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