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In Vitro
In Vitro
Trypanocidal Withanolides and Withanolide Glycosides from Dunalia brachyacantha
Natural Products / Mass Spectrometry / Bolivia / Pharmacognosy / Medicinal Plants / Leishmania / Magnetic Resonance Spectroscopy / Structural Analysis / Biological Sciences / In Vitro / ROOT / Animals / Bacteria / Withanolides / Plant Roots / CHEMICAL SCIENCES / Isolation / Trypanosoma Cruzi / Natural / Solanaceae / Microbial Sensitivity Tests / Trypanocidal Agents / Biological activity / Disaccharides / Ergosterol / Lactones / Glycosides / Plant Leaves / Leishmania / Magnetic Resonance Spectroscopy / Structural Analysis / Biological Sciences / In Vitro / ROOT / Animals / Bacteria / Withanolides / Plant Roots / CHEMICAL SCIENCES / Isolation / Trypanosoma Cruzi / Natural / Solanaceae / Microbial Sensitivity Tests / Trypanocidal Agents / Biological activity / Disaccharides / Ergosterol / Lactones / Glycosides / Plant Leaves
NKX3.1 Activates Cellular Response to DNA Damage
Cancer / DNA damage / DNA repair / Transcription Factors / Apoptosis / Signal Transduction / In Vitro / Humans / Protein Kinases / Mutation / Male / Phosphorylation / Cell nucleus / Cell Cycle Proteins / Signal Transduction / In Vitro / Humans / Protein Kinases / Mutation / Male / Phosphorylation / Cell nucleus / Cell Cycle Proteins
HLA-Derived Peptides as Novel Immunosuppressives
Endocrinology / Genetics / Cardiology / Hematology / Nephrology / Neurology / Oncology / Pulmonology / Rheumatology / Epidemiology / Immunology / Nutrition / Public Health / In Vitro / Allergy / Humans / Animals / Peptides / Cyclosporine / Pediatric / Clinical Sciences / T lymphocytes / In Vivo / Rats / Rat / Protein Conformation / Fetus / Amino Acid Sequence / Heart Transplantation / Chemical Structure / transplantation Immunology / Molecular Structure / Molecular Sequence Data / Neurology / Oncology / Pulmonology / Rheumatology / Epidemiology / Immunology / Nutrition / Public Health / In Vitro / Allergy / Humans / Animals / Peptides / Cyclosporine / Pediatric / Clinical Sciences / T lymphocytes / In Vivo / Rats / Rat / Protein Conformation / Fetus / Amino Acid Sequence / Heart Transplantation / Chemical Structure / transplantation Immunology / Molecular Structure / Molecular Sequence Data
Bioactive Constituents from Asparagus cochinchinensis ⊥
Natural Products / China / Pharmacognosy / Medicinal Plants / Cytotoxicity / Saponins / Structural Analysis / Biological Sciences / LAOS / Cell line / In Vitro / Humans / ROOT / Virus / Alcohol / Plant Roots / CHEMICAL SCIENCES / Chine / Isolation / Acetylation / KB cells / Biological activity / Polyphenol / Molecular Structure / Saponins / Structural Analysis / Biological Sciences / LAOS / Cell line / In Vitro / Humans / ROOT / Virus / Alcohol / Plant Roots / CHEMICAL SCIENCES / Chine / Isolation / Acetylation / KB cells / Biological activity / Polyphenol / Molecular Structure
Anti-infective potential of natural products: How to develop a stronger in vitro ‘proof-of-concept’
Complementary and Alternative Medicine / Plant Biology / Ethnopharmacology / Pharmacognosy / Medicinal Plants / Screening / Phytotherapy / In Vitro / HSV / Humans / Si / Natural Product / Animal Model / PES / HMI / Plant extracts / Quality Standard / Microbial Sensitivity Tests / Plant Extract / EPS / Proof of Concept / Screening / Phytotherapy / In Vitro / HSV / Humans / Si / Natural Product / Animal Model / PES / HMI / Plant extracts / Quality Standard / Microbial Sensitivity Tests / Plant Extract / EPS / Proof of Concept
Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1
Organic Chemistry / Modeling / Prediction / Pharmacokinetics / Molecular modeling / Cercopithecus aethiops / Cell line / In Vitro / Humans / Animals / Resonant Energy Transfer / Bioluminescence / In Vivo / Rats / Molecular Model / Water Solubility / Acetic Acid / ADME / Bioorganic and medicinal Chemistry / Thiazoles / In Silico / Structure activity Relationship / Protein Binding / Chemical Synthesis / Selectivity / Binding affinity / Cercopithecus aethiops / Cell line / In Vitro / Humans / Animals / Resonant Energy Transfer / Bioluminescence / In Vivo / Rats / Molecular Model / Water Solubility / Acetic Acid / ADME / Bioorganic and medicinal Chemistry / Thiazoles / In Silico / Structure activity Relationship / Protein Binding / Chemical Synthesis / Selectivity / Binding affinity
Synthetic biotinylated tetra β(1→5) galactofuranoside for in vitro aspergillosis diagnosis
Organic Chemistry / Serology / In Vitro / Allergy / Humans / Animals / Biotin / Aspergillus fumigatus / Rats / Diagnostic Test / Bioorganic and medicinal Chemistry / Monoclonal Antibody / Aspergillosis / Biotinylation / Animals / Biotin / Aspergillus fumigatus / Rats / Diagnostic Test / Bioorganic and medicinal Chemistry / Monoclonal Antibody / Aspergillosis / Biotinylation
Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors
Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Homocysteine / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis
Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors
Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Homocysteine / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis
In vitro differentiated neural stem cells express functional glial glutamate transporters
Neuroscience / Psychology / Cognitive Science / Stem Cells / Cell Adhesion / Stem Cell / Neural stem cell / In Vitro / Cell Differentiation / Glutamate / Animals / Astrocyte / Central Nervous System / D-Aspartic Acid / Neurons / Differentiation / Fluorescent Antibody Technique / Rats / Sodium / Analysis of Variance / Glial Fibrillary Acidic Protein / Wistar Rats / Neural Stem Cells / Growth Factor / Somatic Cell Count / Neurosciences / Glutamate Transporter / Corpus striatum / Stem Cell / Neural stem cell / In Vitro / Cell Differentiation / Glutamate / Animals / Astrocyte / Central Nervous System / D-Aspartic Acid / Neurons / Differentiation / Fluorescent Antibody Technique / Rats / Sodium / Analysis of Variance / Glial Fibrillary Acidic Protein / Wistar Rats / Neural Stem Cells / Growth Factor / Somatic Cell Count / Neurosciences / Glutamate Transporter / Corpus striatum
Ca2+ transport in isolated mitochondrial vesicles from Leishmania braziliensis promastigotes
Calcium / Mitochondria / Fluorescent Dyes and Reagents / Leishmania / Biological Sciences / In Vitro / Animals / Membrane transport / Cell Fractionation / Electron Transport / Homeostasis / Oxygen Consumption / Calcium Ions / Naphthalenesulfonates / In Vitro / Animals / Membrane transport / Cell Fractionation / Electron Transport / Homeostasis / Oxygen Consumption / Calcium Ions / Naphthalenesulfonates
A novel, broad-spectrum anticancer compound containing the imidazo[4,5-e][1,3]diazepine ring system
Organic Chemistry / Cytotoxicity / Ovarian Cancer / Cell line / In Vitro / Humans / Female / Male / Spectrum / Neoplasms / Biological activity / Ovary / Antitumor Activity / Structure activity Relationship / Chemical Synthesis / Antineoplastic Agents / Heterocyclic compounds / Humans / Female / Male / Spectrum / Neoplasms / Biological activity / Ovary / Antitumor Activity / Structure activity Relationship / Chemical Synthesis / Antineoplastic Agents / Heterocyclic compounds
Archazolid A-15- O -β- d -glucopyranoside and iso -Archazolid B: Potent V-ATPase Inhibitory Polyketides from the Myxobacteria Cystobacter violaceus and Archangium gephyra
Natural Products / Cytotoxicity / Structural Analysis / Biological Sciences / Cell line / In Vitro / Humans / Macrocycle / Mice / Female / Animals / Male / Bacteria / CHEMICAL SCIENCES / Isolation / Natural / Biological activity / Thiazoles / Antineoplastic Agents / Molecular Structure / Macrolides / In Vitro / Humans / Macrocycle / Mice / Female / Animals / Male / Bacteria / CHEMICAL SCIENCES / Isolation / Natural / Biological activity / Thiazoles / Antineoplastic Agents / Molecular Structure / Macrolides
Archazolid A-15-O-β-D-glucopyranoside and iso-Archazolid B: Potent V-ATPase Inhibitory Polyketides from the Myxobacteria Cystobacter violaceus and Archangium gephyra
Natural Products / Cytotoxicity / Structural Analysis / Biological Sciences / Cell line / In Vitro / Humans / Macrocycle / Mice / Female / Animals / Male / Bacteria / CHEMICAL SCIENCES / Isolation / Natural / Biological activity / Thiazoles / Antineoplastic Agents / Molecular Structure / Macrolides / In Vitro / Humans / Macrocycle / Mice / Female / Animals / Male / Bacteria / CHEMICAL SCIENCES / Isolation / Natural / Biological activity / Thiazoles / Antineoplastic Agents / Molecular Structure / Macrolides
Human papillomavirus DNA as a possible index of invasiveness in female genital tract carcinomas
Molecular Biology / HUMAN PAPILLOMAVIRUS / In Vitro / Humans / Correlation / Virus / Female / Polymerase Chain Reaction / Exploration / Neoplasm Invasiveness / Base Sequence / Molecular Sequence Data / Virus / Female / Polymerase Chain Reaction / Exploration / Neoplasm Invasiveness / Base Sequence / Molecular Sequence Data
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors
Organic Chemistry / Signal Transduction / Cell line / In Vitro / Humans / Computer Simulation / Phosphorylation / Bioorganic and medicinal Chemistry / Growth Inhibition / Chemical Synthesis / Protein Kinase Inhibitors / Adenosine Triphosphate / Computer Simulation / Phosphorylation / Bioorganic and medicinal Chemistry / Growth Inhibition / Chemical Synthesis / Protein Kinase Inhibitors / Adenosine Triphosphate
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