Kinase inhibitor

T-588 inhibits astrocyte apoptosis via mitogen-activated protein kinase signal pathway

Apoptosis / Animals / Astrocyte / Kinase inhibitor / Phosphorylation / Astrocytes / Mitogen Activated Protein Kinase / Hydrogen Peroxide / European / Rats / Wistar Rats / Nerve Growth Factor / Reperfusion injury / MAP Kinase / Astrocytes / Mitogen Activated Protein Kinase / Hydrogen Peroxide / European / Rats / Wistar Rats / Nerve Growth Factor / Reperfusion injury / MAP Kinase

T-588 inhibits astrocyte apoptosis via mitogen-activated protein kinase signal pathway

Apoptosis / Animals / Astrocyte / Kinase inhibitor / Phosphorylation / Astrocytes / Mitogen Activated Protein Kinase / Hydrogen Peroxide / European / Rats / Wistar Rats / Nerve Growth Factor / Reperfusion injury / MAP Kinase / Astrocytes / Mitogen Activated Protein Kinase / Hydrogen Peroxide / European / Rats / Wistar Rats / Nerve Growth Factor / Reperfusion injury / MAP Kinase

3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor

Organic Chemistry / Dogs / Mice / Animals / Kinase inhibitor / Amides / Rats / Structure activity Relationship / Physical Properties / Protein Kinase Inhibitors / Molecular Structure / aniline Compounds / Amides / Rats / Structure activity Relationship / Physical Properties / Protein Kinase Inhibitors / Molecular Structure / aniline Compounds

Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways

Flow Cytometry / Mitochondria / Apoptosis / Colorectal cancer / Humans / Cell Death / Kinase inhibitor / Biochemical / Time Dependent / BIOCHEMICAL PHARMACOLOGY / Aurora kinases / Mitochondrial Membrane Potential / Protein Kinase Inhibitors / Benzamides / Quinazolines / Cell Death / Kinase inhibitor / Biochemical / Time Dependent / BIOCHEMICAL PHARMACOLOGY / Aurora kinases / Mitochondrial Membrane Potential / Protein Kinase Inhibitors / Benzamides / Quinazolines

ChemInform Abstract: 4-Anilino-3-cyanobenzo[g]quinolines as Kinase Inhibitors

Kinase inhibitor

Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways

Flow Cytometry / Mitochondria / Apoptosis / Colorectal cancer / Humans / Cell Death / Kinase inhibitor / Biochemical / Time Dependent / BIOCHEMICAL PHARMACOLOGY / Aurora kinases / Mitochondrial Membrane Potential / Protein Kinase Inhibitors / Benzamides / Quinazolines / Cell Death / Kinase inhibitor / Biochemical / Time Dependent / BIOCHEMICAL PHARMACOLOGY / Aurora kinases / Mitochondrial Membrane Potential / Protein Kinase Inhibitors / Benzamides / Quinazolines

3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor

Organic Chemistry / Dogs / Mice / Animals / Kinase inhibitor / Amides / Rats / Structure activity Relationship / Physical Properties / Protein Kinase Inhibitors / Molecular Structure / aniline Compounds / Amides / Rats / Structure activity Relationship / Physical Properties / Protein Kinase Inhibitors / Molecular Structure / aniline Compounds

DNA-PKcs and ATM co-regulate DNA double-strand break repair

Regulation / HR / Radiobiology of Ionizing Radiation / DNA damage / DNA repair / Stability / Ir / Mutation / Animals / Kinase inhibitor / Phosphorylation / Genome / Genetic Recombination / Homologous Recombination / Protein Kinase / Ionizing Radiation / Cell Cycle Proteins / DNA binding proteins / Biochemistry and cell biology / Nhej / DNA double strand breaks / Stability / Ir / Mutation / Animals / Kinase inhibitor / Phosphorylation / Genome / Genetic Recombination / Homologous Recombination / Protein Kinase / Ionizing Radiation / Cell Cycle Proteins / DNA binding proteins / Biochemistry and cell biology / Nhej / DNA double strand breaks

IRAK-4 inhibitors. Part III: A series of imidazo[1,2-a]pyridines

Organic Chemistry / Signal Transduction / In Vitro / Kinase inhibitor / Pyridines / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

IRAK-4 inhibitors. Part III: A series of imidazo[1,2- a]pyridines

Organic Chemistry / Signal Transduction / In Vitro / Kinase inhibitor / Pyridines / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors

Organic Chemistry / Modeling / Pharmacokinetics / Pharmaceutical Chemistry / Signal Transduction / Crystal structure / X Rays / In Vitro / Humans / Animals / Drug Design / Kinase inhibitor / Design Rationale / In Vivo / Hydrazones / Rats / Oximes / Molecular Model / Molecular Conformation / Bioorganic and medicinal Chemistry / Growth Factor / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Receptor Tyrosine Kinase / Crystal structure / X Rays / In Vitro / Humans / Animals / Drug Design / Kinase inhibitor / Design Rationale / In Vivo / Hydrazones / Rats / Oximes / Molecular Model / Molecular Conformation / Bioorganic and medicinal Chemistry / Growth Factor / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Receptor Tyrosine Kinase

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