Macromolecular X-Ray Crystallography - Page 2

Structural, spectroscopic and voltammetric studies of bis(acetazolamido)bis(aquo)bis(nicotinamide)copper(II)

Analytical Chemistry / Macromolecular X-Ray Crystallography / Copper / Hydrogen Bonding / Acetazolamide / Electrodes / Organometallic Compounds / Electrodes / Organometallic Compounds

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Structural, Bioinformatic, and In Vivo Analyses of Two Treponema pallidum Lipoproteins Reveal a Unique TRAP Transporter

Molecular Biology / Computational Biology / Structural Bioinformatics / Macromolecular X-Ray Crystallography / Crystal structure / Membrane transport proteins / Lipoprotein(a) / Perforation / Analytical Ultracentrifugation / Lipoproteins / Chemical Composition / Protein Quaternary Structure / Recombinant Proteins / Protein Binding / Ligands / Biochemistry and cell biology / Membrane transport proteins / Lipoprotein(a) / Perforation / Analytical Ultracentrifugation / Lipoproteins / Chemical Composition / Protein Quaternary Structure / Recombinant Proteins / Protein Binding / Ligands / Biochemistry and cell biology

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Cyclic urea derivatives as potent NK1 selective antagonists

Organic Chemistry / Macromolecular X-Ray Crystallography / Animals / Urea / Fluorine / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Biological Availability / Heterocyclic compounds / Molecular Structure / Neurokinin receptor antagonists / Motor activity / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Biological Availability / Heterocyclic compounds / Molecular Structure / Neurokinin receptor antagonists / Motor activity

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Three-dimensional electron cryo-microscopy as a powerful structural tool in molecular medicine

Pathology / Crystallography / Electron Microscopy / Molecular Biology / Molecular Medicine / RADIATION DAMAGE / Electron Tomography / Transmission Electron Microscopy / Magnetic Resonance Spectroscopy / Macromolecular X-Ray Crystallography / Humans / Image Reconstruction / Viruses / Technique / Three Dimensional Imaging / Nicotinic Acetylcholine Receptors / Protein structure / Proteins / Application / Protein Complex Detection / Cryo Electron Microscopy / Three Dimensional / Three dimensional Reconstruction / Ribosomes / Signal to Noise Ratio / Structure Determination / Molecular Structure / Electron Crystallography / RADIATION DAMAGE / Electron Tomography / Transmission Electron Microscopy / Magnetic Resonance Spectroscopy / Macromolecular X-Ray Crystallography / Humans / Image Reconstruction / Viruses / Technique / Three Dimensional Imaging / Nicotinic Acetylcholine Receptors / Protein structure / Proteins / Application / Protein Complex Detection / Cryo Electron Microscopy / Three Dimensional / Three dimensional Reconstruction / Ribosomes / Signal to Noise Ratio / Structure Determination / Molecular Structure / Electron Crystallography

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Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

Catalysis / Multidisciplinary / Nature / Macromolecular X-Ray Crystallography / Crystal structure / Humans / Animals / Enzyme / Rats / Isoenzymes / Molecular Conformation / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Protein Binding / Hydrolysis / Second Messengers / Phospholipase C / Humans / Animals / Enzyme / Rats / Isoenzymes / Molecular Conformation / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Protein Binding / Hydrolysis / Second Messengers / Phospholipase C

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Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

Catalysis / Multidisciplinary / Nature / Macromolecular X-Ray Crystallography / Crystal structure / Humans / Animals / Enzyme / Rats / Isoenzymes / Molecular Conformation / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Protein Binding / Hydrolysis / Second Messengers / Phospholipase C / Humans / Animals / Enzyme / Rats / Isoenzymes / Molecular Conformation / Protein Conformation / Amino Acid Sequence / Recombinant Proteins / Protein Binding / Hydrolysis / Second Messengers / Phospholipase C

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Beyond Polymaxenolide: Cembrane-Africanane Terpenoids from the Hybrid Soft Coral Sinularia maxima × S. polydactyla

Marine Biology / Natural Products / Macromolecular X-Ray Crystallography / Biological Sciences / Anthozoa / Animals / CHEMICAL SCIENCES / Diterpenes / Molecular Conformation / Molecular Structure / Animals / CHEMICAL SCIENCES / Diterpenes / Molecular Conformation / Molecular Structure

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Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Organic Chemistry / Cytokines / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Humans / Amides / Cell Proliferation / Structure activity Relationship / Antineoplastic Agents / Amides / Cell Proliferation / Structure activity Relationship / Antineoplastic Agents

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Structure of the Archaeal Pab87 Peptidase Reveals a Novel Self-Compartmentalizing Protease Family

Engineering / Physics / Chemistry / Biology / Medicine / Multidisciplinary / Macromolecular X-Ray Crystallography / Protein Turnover / Archaea / Peptides / PLoS one / Active site / Substrate Specificity / Amino Acid Profile / Protein Conformation / Multidisciplinary / Macromolecular X-Ray Crystallography / Protein Turnover / Archaea / Peptides / PLoS one / Active site / Substrate Specificity / Amino Acid Profile / Protein Conformation

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Structural basis for iron piracy by pathogenic Neisseria

Biochemistry / Microbiology / Electron Microscopy / Structural Biology / Molecular Dynamics Simulation / Small angle X-ray and neutron scattering / Small Angle X Ray Scattering / Intelligent Transport System / Multidisciplinary / Nature / Macromolecular X-Ray Crystallography / Crystal structure / Humans / Mice / Animals / Medical Research / Transferrin / Neisseria / Iron / Cattle / X ray diffraction / Protein Conformation / Species Specificity / Structure activity Relationship / Cell Surface Markers / Bacterial meningitis / Outer Membrane Protein / Apoproteins / Small angle X-ray and neutron scattering / Small Angle X Ray Scattering / Intelligent Transport System / Multidisciplinary / Nature / Macromolecular X-Ray Crystallography / Crystal structure / Humans / Mice / Animals / Medical Research / Transferrin / Neisseria / Iron / Cattle / X ray diffraction / Protein Conformation / Species Specificity / Structure activity Relationship / Cell Surface Markers / Bacterial meningitis / Outer Membrane Protein / Apoproteins

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Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi

Organic Chemistry / Treatment / Drug development / Macromolecular X-Ray Crystallography / In Vitro / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure

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Crystal Structure of a Novel Plasmodium falciparum 1-Cys Peroxiredoxin

Water / Molecular Biology / Macromolecular X-Ray Crystallography / Molecular / Crystal structure / Sequence alignment / Animals / Electron Density / Peroxidases / Plasmodium falciparum / Amino Acid Sequence / Protein Quaternary Structure / Biochemistry and cell biology / Solvents / Dimerization / Peroxiredoxins / Sequence alignment / Animals / Electron Density / Peroxidases / Plasmodium falciparum / Amino Acid Sequence / Protein Quaternary Structure / Biochemistry and cell biology / Solvents / Dimerization / Peroxiredoxins

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Yeast d-Amino Acid Oxidase: Structural Basis of its Catalytic Properties

Molecular Biology / Kinetics / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Molecular / Crystal structure / Enzyme / Active site / Substrate Specificity / Amino Acid Profile / Protein Conformation / Yeasts / D structure / Glutathione Reductase / Catalytic Activity / Biochemistry and cell biology / Dimerization / Crystal structure / Enzyme / Active site / Substrate Specificity / Amino Acid Profile / Protein Conformation / Yeasts / D structure / Glutathione Reductase / Catalytic Activity / Biochemistry and cell biology / Dimerization

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Crystal structures of Aedes aegypti kynurenine aminotransferase

Macromolecular X-Ray Crystallography / Crystal structure / Humans / Animals / Recombinant Proteins / Aedes / Biochemistry and cell biology / Molecular Structure / Transaminases / Aedes / Biochemistry and cell biology / Molecular Structure / Transaminases

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Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening

Organic Chemistry / Kinetics / Modeling / Crystallization / Enzyme Inhibitors / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Crystal structure / In Vitro / Virtual screening / Animals / Ligand Binding / Drug Design / Molecular docking / Glycoproteins / Chagas disease / Enzyme / Neuraminidase / Active site / Trypanosoma Cruzi / Ether / Molecular Model / Bioorganic and medicinal Chemistry / Sialic Acid / In Silico / Drug Targeting / Ligands / Trans-Sialidase / Pharmaceutical Chemistry / Macromolecular X-Ray Crystallography / Crystal structure / In Vitro / Virtual screening / Animals / Ligand Binding / Drug Design / Molecular docking / Glycoproteins / Chagas disease / Enzyme / Neuraminidase / Active site / Trypanosoma Cruzi / Ether / Molecular Model / Bioorganic and medicinal Chemistry / Sialic Acid / In Silico / Drug Targeting / Ligands / Trans-Sialidase

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2-[(E)-(4-Hydroxy-3-methoxybenzyl-idene)amino]-N-(2-methylphenyl)-4,5,6, 7-tetrahydro-1-benzothiophene-3-carboxamide

Inorganic Chemistry / Macromolecular X-Ray Crystallography / Hydrogen Bonding / Amides / Molecular Structure

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