Macromolecular X-Ray Crystallography

Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Organic Chemistry / Cytokines / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Humans / Amides / Cell Proliferation / Structure activity Relationship / Antineoplastic Agents / Amides / Cell Proliferation / Structure activity Relationship / Antineoplastic Agents

Lipidic phase membrane protein serial femtosecond crystallography

Technology / Membrane Proteins / Macromolecular X-Ray Crystallography / Biological Sciences / X Rays / Protein Conformation / Lipid bilayers / Membrane Protein / Protein Binding / Protein Conformation / Lipid bilayers / Membrane Protein / Protein Binding

Crystal structure of a dimeric octaheme cytochrome c3 (Mr 26000) from Desulfovibrio desulfuricans Norway

Structure / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Cytochrome C / Sulfate reducing Bacteria / Structure Analysis / Heme / CHEMICAL SCIENCES / Functional Group / Protein Conformation / Amino Acid Sequence / Amino Acid Substitution Rates / Molecular Replacement / Oxidation-Reduction / Desulfovibrio / Sulfate reducing Bacteria / Structure Analysis / Heme / CHEMICAL SCIENCES / Functional Group / Protein Conformation / Amino Acid Sequence / Amino Acid Substitution Rates / Molecular Replacement / Oxidation-Reduction / Desulfovibrio

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

Drug development / Multidisciplinary / Macromolecular X-Ray Crystallography / Mice / Animals / Drug Resistance / Drug Design / Plasmodium falciparum / Antimalarials / Protein Conformation / Molecular Structure / Drug Resistance / Drug Design / Plasmodium falciparum / Antimalarials / Protein Conformation / Molecular Structure

Structure of the Pseudomonas aeruginosa transamidosome reveals unique aspects of bacterial tRNA-dependent asparagine biosynthesis

Molecular Evolution / Multidisciplinary / Macromolecular X-Ray Crystallography / Phylogeny / Pseudomonas aeruginosa / Pseudomonas Aeruginosa / Protein Conformation / Amino Acid Sequence / Asparagine / Pseudomonas Aeruginosa / Protein Conformation / Amino Acid Sequence / Asparagine

A novel series of isoreticular metal organic frameworks: realizing metastable structures by liquid phase epitaxy

Computational Biology / Macromolecular X-Ray Crystallography / Copper / Scientific / Carboxylic Acids / Organometallic Compounds / Molecular Structure / Organometallic Compounds / Molecular Structure

Gambogic Acid, a Natural Product Inhibitor of Hsp90

Natural Products / Macromolecular X-Ray Crystallography / Biological Sciences / CHEMICAL SCIENCES / Natural / Protein Conformation / Cell Cycle Proteins / Benzoquinones / Triterpenes / Chaperonins / Protein Conformation / Cell Cycle Proteins / Benzoquinones / Triterpenes / Chaperonins

Antibodies as a model system for comparative model refinement

Macromolecular X-Ray Crystallography / Biological Sciences / Mathematical Sciences / Proteins / Model System / Comparative modeling / Protein Conformation / Comparative modeling / Protein Conformation

Bendigoles A~C, New Steroids from Gordonia australis Acta 2299†

Microbiology / Mass Spectrometry / Magnetic Resonance Spectroscopy / Macromolecular X-Ray Crystallography / Estrogen Receptor / Progesterone / Humans / Androgens / Secondary Metabolites / High Pressure Liquid Chromatography / Antibiotics / Fermentation / Structure Elucidation / Androgen Receptor / Molecular Structure / Binding affinity / Progesterone / Humans / Androgens / Secondary Metabolites / High Pressure Liquid Chromatography / Antibiotics / Fermentation / Structure Elucidation / Androgen Receptor / Molecular Structure / Binding affinity

Structural Studies on Pax-8 Prd Domain/DNA Complex

Synchrotron Radiation / Macromolecular X-Ray Crystallography / DNA / Protein-DNA interaction / Humans / Transcription Factor / Comparative modeling / Protein Conformation / Amino Acid Sequence / X Ray Diffraction Analysis / Ionic Strength / Protein Binding / DNA binding proteins / Nucleic Acid Conformation / Biochemistry and cell biology / Structure Dynamics / DNA fragmentation / Transcription Factor / Comparative modeling / Protein Conformation / Amino Acid Sequence / X Ray Diffraction Analysis / Ionic Strength / Protein Binding / DNA binding proteins / Nucleic Acid Conformation / Biochemistry and cell biology / Structure Dynamics / DNA fragmentation

Medicinal Chemistry of Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors

Organic Chemistry / Medicinal Chemistry / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Humans / Structure activity Relationship

Structural Asymmetry in a Trimeric Na+/Betaine Symporter, BetP, from Corynebacterium glutamicum

Molecular Biology / EM / Macromolecular X-Ray Crystallography / Molecular / X Rays / Protein Secondary Structure Prediction / Sodium / Rigid Body / Three Dimensional / Atomic Structure / Osmotic Stress / Ion Transport / Glycine Betaine / Structure activity Relationship / D / Conformational Change / PDB / Biochemistry and cell biology / Cc / Betaine / Protein Secondary Structure Prediction / Sodium / Rigid Body / Three Dimensional / Atomic Structure / Osmotic Stress / Ion Transport / Glycine Betaine / Structure activity Relationship / D / Conformational Change / PDB / Biochemistry and cell biology / Cc / Betaine

Crystal structure of NMA1982 from Neisseria meningitidis at 1.5 Å resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases

Protein Science / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Mathematical Sciences / Proteins / Protein Secondary Structure Prediction / Amino Acid Sequence / Proteins / Protein Secondary Structure Prediction / Amino Acid Sequence

ExBox: A Polycyclic Aromatic Hydrocarbon Scavenger

Macromolecular X-Ray Crystallography / CHEMICAL SCIENCES / Polycyclic aromatic hydrocarbons (PAHs) / Molecular Structure

Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosis

Multidisciplinary / Macromolecular X-Ray Crystallography / Crystal structure / Tuberculosis / Sequence alignment / Mycobacterium tuberculosis / Lipid metabolism / PLoS one / Enzyme / Active site / Protein Secondary Structure Prediction / Esterases / Amino Acid Sequence / D structure / Hydrolysis / Mycobacterium tuberculosis / Lipid metabolism / PLoS one / Enzyme / Active site / Protein Secondary Structure Prediction / Esterases / Amino Acid Sequence / D structure / Hydrolysis

Lipidic phase membrane protein serial femtosecond crystallography

Technology / Membrane Proteins / Macromolecular X-Ray Crystallography / Biological Sciences / X Rays / Protein Conformation / Lipid bilayers / Membrane Protein / Protein Binding / Protein Conformation / Lipid bilayers / Membrane Protein / Protein Binding

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