Mechanism of action

Ketotifen effectively prevents mucosal damage in experimental colitis

Inflammatory Immune Response / Inflammatory Bowel Disease / Intestinal Mucosa / Animals / Male / Clinical Sciences / Colitis / Rats / Gut / Acetic Acid / Mechanism of action / Colon / Myeloperoxidase / Prostaglandin E2 / Clinical Sciences / Colitis / Rats / Gut / Acetic Acid / Mechanism of action / Colon / Myeloperoxidase / Prostaglandin E2

RFI-641, a Potent Respiratory Syncytial Virus Inhibitor

Microbiology / Immune response / Medical Microbiology / Cercopithecus aethiops / Mice / United States / Female / Animals / Male / Cytomegalovirus / Temperature / Sigmodontinae / Respiratory Syncytial Virus / Human Respiratory syncytial virus / Rats / Otitis Media / Antimicrobial agents / Young Children / Chronic obstructive pulmonary disease / Mechanism of action / Triazines / Antiviral Activity / Enzyme Linked Immunosorbent Assay / Respiratory Syncytial Virus Infections Industry / Antiviral Agents / Mortality rate / United States / Female / Animals / Male / Cytomegalovirus / Temperature / Sigmodontinae / Respiratory Syncytial Virus / Human Respiratory syncytial virus / Rats / Otitis Media / Antimicrobial agents / Young Children / Chronic obstructive pulmonary disease / Mechanism of action / Triazines / Antiviral Activity / Enzyme Linked Immunosorbent Assay / Respiratory Syncytial Virus Infections Industry / Antiviral Agents / Mortality rate

Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria

Membrane Proteins / Enzyme Inhibitors / Mitochondria / Ion Channels / Dopamine / Cell Differentiation / Animals / Male / Cell Death / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Cell Differentiation / Animals / Male / Cell Death / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology

Akt Inhibitors as Chemosensitizers

DNA damage / Mechanism of action / Multi Drug Resistant Cancer / Growth factor receptor

A Novel Immunocytolytic Factor Secreted by Pancreatic Adenocarcinoma

Apoptosis / Pancreatic Cancer / Spleen / Cell line / Humans / Mice / Female / Animals / Cell Death / Clinical Sciences / Western blot / Mechanism of action / Lymphocytes / Surgical / Culture Media / Adenocarcinoma / Immunoblotting / Fas Ligand / Mice / Female / Animals / Cell Death / Clinical Sciences / Western blot / Mechanism of action / Lymphocytes / Surgical / Culture Media / Adenocarcinoma / Immunoblotting / Fas Ligand

Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria

Membrane Proteins / Enzyme Inhibitors / Mitochondria / Ion Channels / Dopamine / Cell Differentiation / Animals / Male / Cell Death / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Dopamine antagonists / Cell Differentiation / Animals / Male / Cell Death / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Dopamine antagonists

Neurotensin protects pancreatic beta cells from apoptosis

Apoptosis / Signal Transduction / Cell line / Mice / Animals / Cytoprotection / Caspase / Rats / Mechanism of action / Intracellular Space / Biochemistry and cell biology / Neurotensin / Gene Expression Regulation / Pancreatic islets / Cytoprotection / Caspase / Rats / Mechanism of action / Intracellular Space / Biochemistry and cell biology / Neurotensin / Gene Expression Regulation / Pancreatic islets

Neurotensin protects pancreatic beta cells from apoptosis

Apoptosis / Signal Transduction / Cell line / Mice / Animals / Cytoprotection / Caspase / Rats / Mechanism of action / Intracellular Space / Biochemistry and cell biology / Neurotensin / Gene Expression Regulation / Pancreatic islets / Cytoprotection / Caspase / Rats / Mechanism of action / Intracellular Space / Biochemistry and cell biology / Neurotensin / Gene Expression Regulation / Pancreatic islets

Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro

Parasitology / Scanning Electron Microscopy / Humans / Mice / Female / Animals / Male / Ficus / Mode of action / Plant extracts / Ananas / Nematoda / Cysteine endopeptidases / Veterinary Sciences / Mechanism of action / Anthelmintics / PLANT PROTEINS / Cysteine Proteinase Inhibitors / Animals / Male / Ficus / Mode of action / Plant extracts / Ananas / Nematoda / Cysteine endopeptidases / Veterinary Sciences / Mechanism of action / Anthelmintics / PLANT PROTEINS / Cysteine Proteinase Inhibitors

Eletroconvulsoterapia na depressão maior: aspectos atuais Electroconvulsive therapy in major depression: current aspects

Quality of life / Treatment Outcome / Electroconvulsive therapy / Treatment Resistant Depression / Major Depression / Cognitive impairment / Biological treatment / Depressive Symptoms / Mechanism of action / Cognitive impairment / Biological treatment / Depressive Symptoms / Mechanism of action

Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria

Free Radicals / Membrane Proteins / Enzyme Inhibitors / Mitochondria / Ion Channels / Dopamine / Cell Differentiation / Animals / Male / Cell Death / PT / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / CSA / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Dopamine antagonists / Dopamine / Cell Differentiation / Animals / Male / Cell Death / PT / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / CSA / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Dopamine antagonists

A novel secretagogue increases cardiac contractility by enhancement of L-type Ca2+ current

Calcium / Patch-clamp and imaging techniques / Animals / Male / Heart / Biochemical / Steady state / Rats / BIOCHEMICAL PHARMACOLOGY / Mechanism of action / Rabbits / Voltage Clamp / Time Course / Biochemical / Steady state / Rats / BIOCHEMICAL PHARMACOLOGY / Mechanism of action / Rabbits / Voltage Clamp / Time Course

Osteosarcoma associated with hyperparathyroidism

Magnetic Resonance Imaging / Humans / Fibula / Female / Osteosarcoma / Parathyroid Hormone / Clinical Sciences / Middle Aged / Mechanism of action / Hyperparathyroidism / Parathyroid Hormone / Clinical Sciences / Middle Aged / Mechanism of action / Hyperparathyroidism

RFI-641, a Potent Respiratory Syncytial Virus Inhibitor

Microbiology / Immune response / Medical Microbiology / Cercopithecus aethiops / Mice / United States / Female / Animals / Male / Cytomegalovirus / Temperature / Sigmodontinae / Respiratory Syncytial Virus / Human Respiratory syncytial virus / Rats / Otitis Media / Antimicrobial agents / Young Children / Chronic obstructive pulmonary disease / Mechanism of action / Triazines / Antiviral Activity / Enzyme Linked Immunosorbent Assay / Respiratory Syncytial Virus Infections Industry / Antiviral Agents / Mortality rate / Lower Respiratory Tract Infection / United States / Female / Animals / Male / Cytomegalovirus / Temperature / Sigmodontinae / Respiratory Syncytial Virus / Human Respiratory syncytial virus / Rats / Otitis Media / Antimicrobial agents / Young Children / Chronic obstructive pulmonary disease / Mechanism of action / Triazines / Antiviral Activity / Enzyme Linked Immunosorbent Assay / Respiratory Syncytial Virus Infections Industry / Antiviral Agents / Mortality rate / Lower Respiratory Tract Infection
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