Medicinal Chemistry

Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Animals / Trypanosoma brucei / Trypanosoma brucei brucei / Trypanocidal Agents / Amino Acid Sequence / Quinolines / Structure activity Relationship / Ligands / Molecular Structure / Trypanosoma brucei brucei / Trypanocidal Agents / Amino Acid Sequence / Quinolines / Structure activity Relationship / Ligands / Molecular Structure

A Novel Potent Nicotinamide Phosphoribosyltransferase Inhibitor Synthesized via Click Chemistry

Organic Chemistry / Medicinal Chemistry / Enzyme Inhibitors / Autophagy / Humans / Animals / Medicinal / Structure activity Relationship / Protein Binding / Antineoplastic Agents / Alkynes / Animals / Medicinal / Structure activity Relationship / Protein Binding / Antineoplastic Agents / Alkynes

Synthesis of spiro[isobenzofuran-1(3H),4\'-piperidines as potential central nervous system agents. 2. Compounds containing a heteroatom attached to nitrogen

Organic Chemistry / Medicinal Chemistry / Methods / Mice / Animals / Structure activity Relationship / Piperidines / Tetrabenazine / Structure activity Relationship / Piperidines / Tetrabenazine

Novel Antibacterial Class: A Series of Tetracyclic Derivatives

Organic Chemistry / Medicinal Chemistry / Streptococcus pneumoniae / Humans / Anti-Bacterial Agents / Medicinal / Microbial Sensitivity Tests / B Lymphocytes / Structure activity Relationship / Protein Biosynthesis / Medicinal / Microbial Sensitivity Tests / B Lymphocytes / Structure activity Relationship / Protein Biosynthesis

Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Animals / Trypanosoma brucei / Trypanosoma brucei brucei / Trypanocidal Agents / Amino Acid Sequence / Quinolines / Structure activity Relationship / Ligands / Molecular Structure / Trypanosoma brucei brucei / Trypanocidal Agents / Amino Acid Sequence / Quinolines / Structure activity Relationship / Ligands / Molecular Structure

Synthesis and Biological Activity of Aromatic Amino Acid Phosphoramidates of 5-Fluoro-2‘-deoxyuridine and 1-β-Arabinofuranosylcytosine: Evidence of Phosphoramidase Activity

Organic Chemistry / Medicinal Chemistry / Magnetic Resonance Spectroscopy / Cell Division / Cell line / Humans / Mice / Animals / Aromatic amino acid / Organophosphorus Compounds / Biological activity / Humans / Mice / Animals / Aromatic amino acid / Organophosphorus Compounds / Biological activity

Phosphoramidate Dinucleosides as Hepatitis C Virus Polymerase Inhibitors

Organic Chemistry / Medicinal Chemistry / Modeling / Enzyme Inhibitors / Magnetic Resonance Spectroscopy / In Vitro / Humans / Virus / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Molecular Model / Nucleosides / Chemical Synthesis / Oxidation-Reduction / In Vitro / Humans / Virus / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Molecular Model / Nucleosides / Chemical Synthesis / Oxidation-Reduction

Phosphoramidate Dinucleosides as Hepatitis C Virus Polymerase Inhibitors

Organic Chemistry / Medicinal Chemistry / Modeling / Enzyme Inhibitors / Magnetic Resonance Spectroscopy / In Vitro / Humans / Virus / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Molecular Model / Nucleosides / Chemical Synthesis / Oxidation-Reduction / In Vitro / Humans / Virus / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Molecular Model / Nucleosides / Chemical Synthesis / Oxidation-Reduction

These Gael Temgue Pharmacy 2015

Medicinal Chemistry / Computational Drug Designing / Chemical Engineering Plant Design / Farmaceutical Plants

Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid

Organic Chemistry / Medicinal Chemistry / Epilepsy / Mice / Animals / Male / Rats / Valproic Acid / Structure activity Relationship / Male / Rats / Valproic Acid / Structure activity Relationship

ChemInform Abstract: Extended Aromatic Furan Amidino Derivatives as Anti-Pneumocystis carinii Agents

Organic Chemistry / Medicinal Chemistry

Aspectos químicos, biológicos e etnofarmacológicos do gênero Cassia

Medicinal Chemistry / CHEMICAL SCIENCES / Quimica Nova

Cinnamomun cassia, Ficus carica and Fumaria officinalis possesses aphrodisiac activity in male Wister rats

Medicinal Chemistry / Phytopharmacology / Aphrodisiac Plants

A Prodomain Peptide of Plasmodium falciparum Cysteine Protease (Falcipain-2) Inhibits Malaria Parasite Development

Organic Chemistry / Medicinal Chemistry / Animals / Peptides / Medicinal / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Structure activity Relationship / Erythrocytes / Hydrolysis / Hemoglobins / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Structure activity Relationship / Erythrocytes / Hydrolysis / Hemoglobins

A prodomain peptide of plasmodium falciparum cysteine protease (falcipain-2) inhibits malaria parasite development

Organic Chemistry / Medicinal Chemistry / Animals / Peptides / Medicinal / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Structure activity Relationship / Erythrocytes / Hydrolysis / Hemoglobins / Plasmodium falciparum / Antimalarials / Cysteine endopeptidases / Structure activity Relationship / Erythrocytes / Hydrolysis / Hemoglobins

N 1 -Benzoyl- N 2 -[1-(1-naphthyl)ethyl]- trans -1,2-diaminocyclohexanes: Development of 4-Chlorophenylcarboxamide (Calhex 231) as a New Calcium Sensing Receptor Ligand Demonstrating Potent Calcilytic Activity

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Animals / Calcium Sensing Receptor / Rats / Medicinal / Protein Conformation / Structure activity Relationship / Ligands / Benzamides / Molecular Structure / Rats / Medicinal / Protein Conformation / Structure activity Relationship / Ligands / Benzamides / Molecular Structure

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