Mitochondrial dysfunction

Mitochondria: a hub of redox activities and cellular distress control

Genetics / Aging / Oxidative Stress / Mitochondria / Ion Channels / Energy Metabolism / Antioxidants / Mitochondrial DNA / Humans / Reactive Oxygen Species / Stress response / Animals / Cell Death / Cytochrome C / Calcium Signaling / Drug Delivery Systems / Evolutionary History / Electron Transport / Biological evolution / Mitochondrial dysfunction / Mitochondrial Diseases / Calcium Homeostasis / Cell Survival / Oxidation-Reduction / Molecular and Cellular Biochemistry / Low molecular weight / Biochemistry and cell biology / Mitochondrial Proteins / Energy Metabolism / Antioxidants / Mitochondrial DNA / Humans / Reactive Oxygen Species / Stress response / Animals / Cell Death / Cytochrome C / Calcium Signaling / Drug Delivery Systems / Evolutionary History / Electron Transport / Biological evolution / Mitochondrial dysfunction / Mitochondrial Diseases / Calcium Homeostasis / Cell Survival / Oxidation-Reduction / Molecular and Cellular Biochemistry / Low molecular weight / Biochemistry and cell biology / Mitochondrial Proteins

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Mitochondria: a hub of redox activities and cellular distress control

Genetics / Aging / Oxidative Stress / Mitochondria / Ion Channels / Energy Metabolism / Antioxidants / Mitochondrial DNA / Humans / Reactive Oxygen Species / Stress response / Animals / Cell Death / Cytochrome C / Calcium Signaling / Drug Delivery Systems / Evolutionary History / Electron Transport / Biological evolution / Mitochondrial dysfunction / Mitochondrial Diseases / Calcium Homeostasis / Cell Survival / Oxidation-Reduction / Molecular and Cellular Biochemistry / Low molecular weight / Biochemistry and cell biology / Mitochondrial Proteins / Energy Metabolism / Antioxidants / Mitochondrial DNA / Humans / Reactive Oxygen Species / Stress response / Animals / Cell Death / Cytochrome C / Calcium Signaling / Drug Delivery Systems / Evolutionary History / Electron Transport / Biological evolution / Mitochondrial dysfunction / Mitochondrial Diseases / Calcium Homeostasis / Cell Survival / Oxidation-Reduction / Molecular and Cellular Biochemistry / Low molecular weight / Biochemistry and cell biology / Mitochondrial Proteins

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The mitochondrial protease HtrA2 is regulated by Parkinson\'s disease-associated kinase PINK1

MAP Kinase pathway and its regulation / Signal Transduction / Biological Sciences / Cell line / Brain / Humans / Protein Kinases / Mutation / Mice / Animals / Phosphorylation / Mitochondrial dysfunction / Protein Kinase / Autosomal Recessive / Serine Protease / Site-directed Mutagenesis / Parkinson Disease / Proteolytic activity / Mitochondrial Proteins / Humans / Protein Kinases / Mutation / Mice / Animals / Phosphorylation / Mitochondrial dysfunction / Protein Kinase / Autosomal Recessive / Serine Protease / Site-directed Mutagenesis / Parkinson Disease / Proteolytic activity / Mitochondrial Proteins

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Mitochondrial DNA maintenance and bioenergetics

Mitochondria / DNA damage / DNA repair / Energy Metabolism / Biological Sciences / Mitochondrial DNA / Humans / Reactive Oxygen Species / Animals / Physical sciences / Mitochondrial Genome / Enzyme / Mitochondrial dysfunction / Oxidative Damage / Oxidative phosphorylation / Base Excision Repair / Biochemistry and cell biology / Mitochondrial DNA / Humans / Reactive Oxygen Species / Animals / Physical sciences / Mitochondrial Genome / Enzyme / Mitochondrial dysfunction / Oxidative Damage / Oxidative phosphorylation / Base Excision Repair / Biochemistry and cell biology

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Nitric Oxide Induces Osteoblast Apoptosis through a Mitochondria-Dependent Pathway

Mitochondria / Apoptosis / Multidisciplinary / Caspases / Reactive Oxygen Species / Nitric oxide / Animals / Cytochrome C / Cell Viability / Alkaline phosphatase / Caspase / Mitochondrial dysfunction / alkaline phosphatase activity (APA) / Rats / Time Dependent / Wistar Rats / Bone remodeling / Osteoblasts / Mitochondrial Membrane Potential / Sodium Nitroprusside / Experimental Model / Nitric oxide / Animals / Cytochrome C / Cell Viability / Alkaline phosphatase / Caspase / Mitochondrial dysfunction / alkaline phosphatase activity (APA) / Rats / Time Dependent / Wistar Rats / Bone remodeling / Osteoblasts / Mitochondrial Membrane Potential / Sodium Nitroprusside / Experimental Model

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Mitochondrial pharmaceutics

Genetics / Mitochondrial dysfunction

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Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells

Neuroscience / Psychology / Toxicology / Fluorescence Microscopy / Neurochemistry / Mitochondria / Molecular Mechanics / Energy Metabolism / Cytoskeleton / Antioxidants / Aluminum / Humans / Astrocyte / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Astrocytes / Creatine Kinase / Mitochondrial dysfunction / N-Acetylcysteine / Neurosciences / Adenosine Triphosphate / Immunoblotting / Mitochondria / Molecular Mechanics / Energy Metabolism / Cytoskeleton / Antioxidants / Aluminum / Humans / Astrocyte / Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis / Astrocytes / Creatine Kinase / Mitochondrial dysfunction / N-Acetylcysteine / Neurosciences / Adenosine Triphosphate / Immunoblotting

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Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria

Membrane Proteins / Enzyme Inhibitors / Mitochondria / Ion Channels / Dopamine / Cell Differentiation / Animals / Male / Cell Death / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Cell Differentiation / Animals / Male / Cell Death / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology

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Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria

Membrane Proteins / Enzyme Inhibitors / Mitochondria / Ion Channels / Dopamine / Cell Differentiation / Animals / Male / Cell Death / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Dopamine antagonists / Cell Differentiation / Animals / Male / Cell Death / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Dopamine antagonists

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Mitochondria as determinant of nucleotide pools and chromosomal stability

Mitochondria / DNA repair / Cell line / Mitochondrial DNA / Humans / Mutation / Mitochondrial Genome / Comet Assay / Mitochondrial dysfunction / HeLa cells / Human Disease / Chromosomal Instability / Nucleotides / Mutation / Mitochondrial Genome / Comet Assay / Mitochondrial dysfunction / HeLa cells / Human Disease / Chromosomal Instability / Nucleotides

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Nitric Oxide Induces Osteoblast Apoptosis through a Mitochondria-Dependent Pathway

Mitochondria / Apoptosis / Multidisciplinary / Caspases / Reactive Oxygen Species / Nitric oxide / Animals / Cytochrome C / Cell Viability / Alkaline phosphatase / Caspase / Mitochondrial dysfunction / alkaline phosphatase activity (APA) / Rats / Time Dependent / Wistar Rats / Bone remodeling / Osteoblasts / Mitochondrial Membrane Potential / Sodium Nitroprusside / Experimental Model / Nitric oxide / Animals / Cytochrome C / Cell Viability / Alkaline phosphatase / Caspase / Mitochondrial dysfunction / alkaline phosphatase activity (APA) / Rats / Time Dependent / Wistar Rats / Bone remodeling / Osteoblasts / Mitochondrial Membrane Potential / Sodium Nitroprusside / Experimental Model

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Mitochondrial pharmaceutics

Genetics / Arsenic / Gene Therapy / Drug delivery / Ischemia Reperfusion Injury / Mitochondrial dysfunction / Neuromuscular Disease / Biological activity / Drug Targeting / Mitochondrion / Mitochondrial dysfunction / Neuromuscular Disease / Biological activity / Drug Targeting / Mitochondrion

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Mitochondrial pharmaceutics

Genetics / Arsenic / Gene Therapy / Drug delivery / Ischemia Reperfusion Injury / Mitochondrial dysfunction / Neuromuscular Disease / Biological activity / Drug Targeting / Mitochondrion / Mitochondrial dysfunction / Neuromuscular Disease / Biological activity / Drug Targeting / Mitochondrion

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Mitochondrial involvement in temporal lobe epilepsy

Psychology / Calcium / Mitochondria / Neuronal cell death / Brain / Mitochondrial DNA / Humans / Animals / Cell Death / Temporal Lobe Epilepsy / Animal Model / Mitochondrial Respiratory Chain / Phosphorylation / Synaptic Transmission / Neurons / Clinical Sciences / Mitochondrial dysfunction / Oxidative phosphorylation / Experimental Neurology / Neurosciences / Adenosine Triphosphate / Neuroprotective Agents / Mitochondrial DNA / Humans / Animals / Cell Death / Temporal Lobe Epilepsy / Animal Model / Mitochondrial Respiratory Chain / Phosphorylation / Synaptic Transmission / Neurons / Clinical Sciences / Mitochondrial dysfunction / Oxidative phosphorylation / Experimental Neurology / Neurosciences / Adenosine Triphosphate / Neuroprotective Agents

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Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria

Free Radicals / Membrane Proteins / Enzyme Inhibitors / Mitochondria / Ion Channels / Dopamine / Cell Differentiation / Animals / Male / Cell Death / PT / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / CSA / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Dopamine antagonists / Dopamine / Cell Differentiation / Animals / Male / Cell Death / PT / Substantia nigra / Cyclosporine / Respiration / Neuronal Differentiation / Mitochondrial dysfunction / Rats / CSA / Disease Progression / Mechanism of action / Nerve Growth Factor / Trifluoperazine / Monoamine oxidase / Parkinson Disease / Biochemistry and cell biology / Dopamine antagonists

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