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Protein Kinase Inhibitors
Protein Kinase Inhibitors
Amino acid derived quinazolines as Rock/PKA inhibitors
Organic Chemistry / Humans / Rock / PKA / Amino Acids / Structure activity Relationship / Protein Binding / Protein Kinase Inhibitors / Quinazolines / Structure activity Relationship / Protein Binding / Protein Kinase Inhibitors / Quinazolines
Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects
Cell line / Humans / Mutation / Microglia / Neurons / Haploinsufficiency / Frontotemporal Dementia / Induced Pluripotent Stem Cells / Staurosporine / Protein Kinase Inhibitors / Down-Regulation / Haploinsufficiency / Frontotemporal Dementia / Induced Pluripotent Stem Cells / Staurosporine / Protein Kinase Inhibitors / Down-Regulation
Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects
Cell line / Humans / Mutation / Microglia / Neurons / Haploinsufficiency / Frontotemporal Dementia / Induced Pluripotent Stem Cells / Staurosporine / Protein Kinase Inhibitors / Down-Regulation / Haploinsufficiency / Frontotemporal Dementia / Induced Pluripotent Stem Cells / Staurosporine / Protein Kinase Inhibitors / Down-Regulation
Intravitreal Fasudil Combined With Bevacizumab for Persistent Diabetic Macular Edema
Persistence / Optical coherence tomography / Visual acuity / Prospective studies / Humans / Diabetic Retinopathy / Female / Male / Retina / Aged / Middle Aged / Combination drug therapy / Pilot Projects / Protein Kinase Inhibitors / Macular edema / Intravitreal Injections / Diabetic Retinopathy / Female / Male / Retina / Aged / Middle Aged / Combination drug therapy / Pilot Projects / Protein Kinase Inhibitors / Macular edema / Intravitreal Injections
A novel CDPK1 inhibitor—a potential treatment for cryptosporidiosis in calves?
Microbiology / Parasitology / Medical Microbiology / Diarrhea / Protein Kinases / Animals / Cattle / Veterinary Sciences / Protein Kinase Inhibitors / Cryptosporidiosis / Animals / Cattle / Veterinary Sciences / Protein Kinase Inhibitors / Cryptosporidiosis
Contemporary management of sinonasal cancer
Dentistry / Quality of life / Radiation Therapy / Treatment Outcome / Endoscopy / Head and Neck / Humans / Monoclonal Antibodies / Clinical Sciences / Head / Survival Rate / Nasal cavity / Antineoplastic Agents / Protein Kinase Inhibitors / Lymph nodes / Head and Neck / Humans / Monoclonal Antibodies / Clinical Sciences / Head / Survival Rate / Nasal cavity / Antineoplastic Agents / Protein Kinase Inhibitors / Lymph nodes
Synthesis of 6′-acylamido-6′-deoxy-α-d-galactoglycerolipids
Organic Chemistry / Membrane Proteins / Humans / Structure activity Relationship / Glycolipid / Carbohydrate / Protein Kinase Inhibitors / Biochemistry and cell biology / Carbohydrate / Protein Kinase Inhibitors / Biochemistry and cell biology
Amino acid derived quinazolines as Rock/PKA inhibitors
Organic Chemistry / Humans / Amino Acids / Structure activity Relationship / Protein Binding / Protein Kinase Inhibitors / Quinazolines / Protein Kinase Inhibitors / Quinazolines
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors
Organic Chemistry / Humans / Computer Simulation / Phosphorylation / Bioorganic and medicinal Chemistry / Growth Inhibition / Protein Kinase Inhibitors / Adenosine Triphosphate / Growth Inhibition / Protein Kinase Inhibitors / Adenosine Triphosphate
3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor
Organic Chemistry / Dogs / Mice / Animals / Kinase inhibitor / Amides / Rats / Structure activity Relationship / Physical Properties / Protein Kinase Inhibitors / Molecular Structure / aniline Compounds / Amides / Rats / Structure activity Relationship / Physical Properties / Protein Kinase Inhibitors / Molecular Structure / aniline Compounds
Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways
Flow Cytometry / Mitochondria / Apoptosis / Colorectal cancer / Humans / Cell Death / Kinase inhibitor / Biochemical / Time Dependent / BIOCHEMICAL PHARMACOLOGY / Aurora kinases / Mitochondrial Membrane Potential / Protein Kinase Inhibitors / Benzamides / Quinazolines / Cell Death / Kinase inhibitor / Biochemical / Time Dependent / BIOCHEMICAL PHARMACOLOGY / Aurora kinases / Mitochondrial Membrane Potential / Protein Kinase Inhibitors / Benzamides / Quinazolines
Cardioprotective effects of Ilex paraguariensis extract: evidence for a nitric oxide-dependent mechanism
Nutrition and Dietetics / Phytotherapy / Clinical Nutrition / Nitric oxide / Animals / Alkaloids / Ilex paraguariensis / Plant extracts / Rats / Nitric Oxide Synthase / Wistar Rats / Reperfusion injury / Ischemia–reperfusion / Protein Kinase Inhibitors / Plant Leaves / Alkaloids / Ilex paraguariensis / Plant extracts / Rats / Nitric Oxide Synthase / Wistar Rats / Reperfusion injury / Ischemia–reperfusion / Protein Kinase Inhibitors / Plant Leaves
Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors
Organic Chemistry / Cancer / Levels of selection / Signal Transduction / Cell line / In Vitro / Humans / Amines / Caspase / Akt / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Selectivity / Piperidines / In Vitro / Humans / Amines / Caspase / Akt / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Selectivity / Piperidines
Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways
Flow Cytometry / Mitochondria / Apoptosis / Colorectal cancer / Humans / Cell Death / Kinase inhibitor / Biochemical / Time Dependent / BIOCHEMICAL PHARMACOLOGY / Aurora kinases / Mitochondrial Membrane Potential / Protein Kinase Inhibitors / Benzamides / Quinazolines / Cell Death / Kinase inhibitor / Biochemical / Time Dependent / BIOCHEMICAL PHARMACOLOGY / Aurora kinases / Mitochondrial Membrane Potential / Protein Kinase Inhibitors / Benzamides / Quinazolines
Contemporary management of sinonasal cancer
Dentistry / Quality of life / Radiation Therapy / Treatment Outcome / Endoscopy / Head and Neck / Humans / Monoclonal Antibodies / Clinical Sciences / Head / Survival Rate / Nasal cavity / Antineoplastic Agents / Protein Kinase Inhibitors / Lymph nodes / Head and Neck / Humans / Monoclonal Antibodies / Clinical Sciences / Head / Survival Rate / Nasal cavity / Antineoplastic Agents / Protein Kinase Inhibitors / Lymph nodes
Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability
Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure
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