Pyrazoles

Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors

Organic Chemistry / Enzyme Inhibitors / Mitochondria / Mice / Animals / Drug Design / European / Pyrazoles / Structure activity Relationship / Molecular Structure / Drug Design / European / Pyrazoles / Structure activity Relationship / Molecular Structure

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: A new class of CDK2 inhibitors

Organic Chemistry / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Humans / Bioorganic and medicinal Chemistry / Cell Proliferation / Pyrazoles / Aurora kinases / Structure activity Relationship / Antineoplastic Agents / Molecular Structure / Cell Proliferation / Pyrazoles / Aurora kinases / Structure activity Relationship / Antineoplastic Agents / Molecular Structure

Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling

Psychology / Neuropharmacology / Drug interactions / Synaptic Plasticity / Patch-clamp and imaging techniques / Signal Transduction / Dopamine / Glutamate / Habit Formation / Animals / Negative Feedback / dopamine receptor D4 / Synaptic Transmission / Neurons / Rats / Basal ganglia / Endocannabinoids / Pyrazoles / Quinolines / Neurosciences / Neurotensin / Intracellular Calcium / Piperidines / Phospholipase C / Signal Transduction / Dopamine / Glutamate / Habit Formation / Animals / Negative Feedback / dopamine receptor D4 / Synaptic Transmission / Neurons / Rats / Basal ganglia / Endocannabinoids / Pyrazoles / Quinolines / Neurosciences / Neurotensin / Intracellular Calcium / Piperidines / Phospholipase C

Prefrontal cortical anandamide signaling coordinates coping responses to stress through a serotonergic pathway

Enzyme Inhibitors / Prefrontal Cortex / Signal Transduction / Animals / Male / Rats / Endocannabinoids / Pyrazoles / Action Potentials / Carbamates / Benzamides / Piperidines / Rats / Endocannabinoids / Pyrazoles / Action Potentials / Carbamates / Benzamides / Piperidines

Familiar drugs may prevent cancer

Treatment / Cancer Prevention / Folic acid / Prevention / Colorectal cancer / Vitamin A / Humans / Postgraduate medical education / Female / Male / Squamous Cell Carcinoma / Aspirin / Tamoxifen / Neoplasms / Large Scale / Pyrazoles / Angiotensin Converting Enzyme Inhibitors / Raloxifene / Vitamin A / Humans / Postgraduate medical education / Female / Male / Squamous Cell Carcinoma / Aspirin / Tamoxifen / Neoplasms / Large Scale / Pyrazoles / Angiotensin Converting Enzyme Inhibitors / Raloxifene

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Modelling of UV-molecular spectra of several bis-pyrazolopyridines derivatives

Analytical Chemistry / Pyridines / Pyrazoles / Molecular Structure

Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors

Organic Chemistry / Enzyme Inhibitors / Tight Binding / Bioorganic and medicinal Chemistry / Pyrazoles

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