Structure activity Relationship - Page 3

Cyclic urea derivatives as potent NK1 selective antagonists

Organic Chemistry / Macromolecular X-Ray Crystallography / Animals / Urea / Fluorine / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Biological Availability / Heterocyclic compounds / Molecular Structure / Neurokinin receptor antagonists / Motor activity / Rats / Bioorganic and medicinal Chemistry / Structure activity Relationship / Protein Binding / Biological Availability / Heterocyclic compounds / Molecular Structure / Neurokinin receptor antagonists / Motor activity

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RNA structural features responsible for potato spindle tuber viroid pathogenicity

Thermodynamics / Virology / Potato / Biological Sciences / Plant viruses / Secondary Structure / Viroids / Structural Properties / Three Dimensional / Genetic variation / Solanum Tuberosum / RNA Structure / Base Sequence / Structure activity Relationship / Nucleic Acid Conformation / Nucleotides / Melting Temperature / Molecular Sequence Data / Secondary Structure / Viroids / Structural Properties / Three Dimensional / Genetic variation / Solanum Tuberosum / RNA Structure / Base Sequence / Structure activity Relationship / Nucleic Acid Conformation / Nucleotides / Melting Temperature / Molecular Sequence Data

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Natural Occurring Polyphenols as Template for Drug Design. Focus on Serine Proteases

Flavonoids / Polyphenols / Drug Design / Phenols / Structure activity Relationship / Serine Protease / Biochemistry and cell biology / Serine Protease / Biochemistry and cell biology

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5-Nitro-2-furyl derivative actives against Trypanosoma cruzi: Preliminary in vivo studies

Organic Chemistry / Mice / Female / Animals / Chagas disease / European / Trypanosoma Cruzi / Nifurtimox / Trypanocidal Agents / Murine Model / Structure activity Relationship / Acute Toxicity / Chemical Structure / European / Trypanosoma Cruzi / Nifurtimox / Trypanocidal Agents / Murine Model / Structure activity Relationship / Acute Toxicity / Chemical Structure

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Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase

Organic Chemistry / Enzyme Inhibitors / Humans / Mice / Blood Pressure / Animals / Male / Drug Design / Solubility / Time Factors / Functional Group / Bioorganic and medicinal Chemistry / Structure activity Relationship / Adamantane / Physical Properties / Molecular Structure / Animals / Male / Drug Design / Solubility / Time Factors / Functional Group / Bioorganic and medicinal Chemistry / Structure activity Relationship / Adamantane / Physical Properties / Molecular Structure

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Ceramide Structure Predicts Tumor Ganglioside Immunosuppressive Activity

Protein Structure Prediction / Multidisciplinary / Brain / Humans / Mice / Animals / Neuroblastoma / Neoplasms / Fatty Acid / Biological activity / Immune Tolerance / Structure activity Relationship / Brain Chemistry / Gangliosides / Ceramides / Animals / Neuroblastoma / Neoplasms / Fatty Acid / Biological activity / Immune Tolerance / Structure activity Relationship / Brain Chemistry / Gangliosides / Ceramides

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A Novel Potent Nicotinamide Phosphoribosyltransferase Inhibitor Synthesized via Click Chemistry

Organic Chemistry / Medicinal Chemistry / Enzyme Inhibitors / Autophagy / Humans / Animals / Medicinal / Structure activity Relationship / Protein Binding / Antineoplastic Agents / Alkynes / Animals / Medicinal / Structure activity Relationship / Protein Binding / Antineoplastic Agents / Alkynes

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Preliminary crystal structure of Acinetobacter glutaminasificans glutaminase-asparaginase

Crystallization / Biological Chemistry / Biological Sciences / Escherichia coli / Pseudomonas / CHEMICAL SCIENCES / L-asparaginase / Vibrio / X ray diffraction / Acinetobacter / Protein Conformation / Structure activity Relationship / CHEMICAL SCIENCES / L-asparaginase / Vibrio / X ray diffraction / Acinetobacter / Protein Conformation / Structure activity Relationship

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Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Organic Chemistry / Cytokines / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Humans / Amides / Cell Proliferation / Structure activity Relationship / Antineoplastic Agents / Amides / Cell Proliferation / Structure activity Relationship / Antineoplastic Agents

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Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors

Organic Chemistry / Nitriles / Protease Inhibitors / Cyclization / Bioorganic and medicinal Chemistry / Type 2 Diabetes Mellitus / Structure activity Relationship / Molecular Structure / Type 2 Diabetes Mellitus / Structure activity Relationship / Molecular Structure

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Arylfurans as potential Trypanosoma cruzi trypanothione reductase inhibitors

Medical Microbiology / Enzyme Inhibitors / Mice / Animals / Male / Chagas disease / Total Synthesis / Trypanosoma Cruzi / Trypanocidal Agents / Structure activity Relationship / Furans / Chagas disease / Total Synthesis / Trypanosoma Cruzi / Trypanocidal Agents / Structure activity Relationship / Furans

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Tetrahydrobenzothiophenone Derivatives as a Novel Class of Adenosine Receptor Antagonists †

Organic Chemistry / Medicinal Chemistry / Humans / Mice / Animals / Male / Rats / Structure activity Relationship / Motor activity / Male / Rats / Structure activity Relationship / Motor activity

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Structural basis for iron piracy by pathogenic Neisseria

Biochemistry / Microbiology / Electron Microscopy / Structural Biology / Molecular Dynamics Simulation / Small angle X-ray and neutron scattering / Small Angle X Ray Scattering / Intelligent Transport System / Multidisciplinary / Nature / Macromolecular X-Ray Crystallography / Crystal structure / Humans / Mice / Animals / Medical Research / Transferrin / Neisseria / Iron / Cattle / X ray diffraction / Protein Conformation / Species Specificity / Structure activity Relationship / Cell Surface Markers / Bacterial meningitis / Outer Membrane Protein / Apoproteins / Small angle X-ray and neutron scattering / Small Angle X Ray Scattering / Intelligent Transport System / Multidisciplinary / Nature / Macromolecular X-Ray Crystallography / Crystal structure / Humans / Mice / Animals / Medical Research / Transferrin / Neisseria / Iron / Cattle / X ray diffraction / Protein Conformation / Species Specificity / Structure activity Relationship / Cell Surface Markers / Bacterial meningitis / Outer Membrane Protein / Apoproteins

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Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi

Organic Chemistry / Treatment / Drug development / Macromolecular X-Ray Crystallography / In Vitro / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure

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Natural Chromenes and Chromene Derivatives as Potential Anti-trypanosomal Agents

Plant Biology / Animals / Biological / Trypanosoma Cruzi / Trypanocidal Agents / Structure activity Relationship / Piper / Structure activity Relationship / Piper

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Probing active-site residues of pyranose 2-oxidase from Trametes multicolor by semi-rational protein design

Kinetics / Biotechnology / Industrial Biotechnology / Gene expression / Protein Engineering / Environmental Biotechnology / Biocatalysis / Protein Design / Mutation / Escherichia coli / Medical Biotechnology / Temperature / Hydrogen Bonding / Theoretical Models / Active site / Protein Secondary Structure Prediction / Buffers / Substrate Specificity / Bioreactors / Phosphates / Amino Acid Sequence / Structure activity Relationship / Recombinant Proteins / Protein Binding / Hydrogen-Ion Concentration / Site-directed Mutagenesis / Oxidation-Reduction / Environmental Biotechnology / Biocatalysis / Protein Design / Mutation / Escherichia coli / Medical Biotechnology / Temperature / Hydrogen Bonding / Theoretical Models / Active site / Protein Secondary Structure Prediction / Buffers / Substrate Specificity / Bioreactors / Phosphates / Amino Acid Sequence / Structure activity Relationship / Recombinant Proteins / Protein Binding / Hydrogen-Ion Concentration / Site-directed Mutagenesis / Oxidation-Reduction

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