Structure activity Relationship

3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor

Organic Chemistry / Dogs / Mice / Animals / Kinase inhibitor / Amides / Rats / Structure activity Relationship / Physical Properties / Protein Kinase Inhibitors / Molecular Structure / aniline Compounds / Amides / Rats / Structure activity Relationship / Physical Properties / Protein Kinase Inhibitors / Molecular Structure / aniline Compounds

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: A new class of CDK2 inhibitors

Organic Chemistry / Enzyme Inhibitors / Macromolecular X-Ray Crystallography / Humans / Bioorganic and medicinal Chemistry / Cell Proliferation / Pyrazoles / Aurora kinases / Structure activity Relationship / Antineoplastic Agents / Molecular Structure / Cell Proliferation / Pyrazoles / Aurora kinases / Structure activity Relationship / Antineoplastic Agents / Molecular Structure

Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

Organic Chemistry / Magnetic Resonance Spectroscopy / Phenols / Radioligand Assay / Bioorganic and medicinal Chemistry / Biological activity / Structure activity Relationship / Piperidines / Biological activity / Structure activity Relationship / Piperidines

Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

Organic Chemistry / Amides / Bioorganic and medicinal Chemistry / Biological activity / Benzimidazoles / Structure activity Relationship / Molecular Structure / Formalin Test / Structure activity Relationship / Molecular Structure / Formalin Test

Oxamides as novel NR2B selective NMDA receptor antagonists

Organic Chemistry / Mice / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Formalin Test / Molecular Structure / Formalin Test

Potent 4-amino-5-azaindole factor VIIa inhibitors

Organic Chemistry / Pyridines / Bioorganic and medicinal Chemistry / Structure activity Relationship / Serine Protease / Tissue Factor / Molecular Structure / Tissue Factor / Molecular Structure

N-Caffeoylphenalkylamide derivatives as bacterial efflux pump inhibitors

Organic Chemistry / Multidrug Resistance / Natural Product / Bacteria / Staphylococcus aureus / Membrane transport proteins / Anti-Bacterial Agents / Plant extracts / Amides / Microbial Sensitivity Tests / Reserpine / Structure activity Relationship / Norfloxacin / Membrane transport proteins / Anti-Bacterial Agents / Plant extracts / Amides / Microbial Sensitivity Tests / Reserpine / Structure activity Relationship / Norfloxacin

N-1H-Benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists

Organic Chemistry / Drug metabolism / Nuclear Receptor / Cell line / Humans / Drug Design / Enzyme / Bioorganic and medicinal Chemistry / Primary Culture / Benzimidazoles / Human Disease / Structure activity Relationship / Chemical Modification / Molecular Structure / Gene Expression Regulation / Pregnane X Receptor / Drug Design / Enzyme / Bioorganic and medicinal Chemistry / Primary Culture / Benzimidazoles / Human Disease / Structure activity Relationship / Chemical Modification / Molecular Structure / Gene Expression Regulation / Pregnane X Receptor

Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi

Organic Chemistry / Drug development / Macromolecular X-Ray Crystallography / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Molecular Structure / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Molecular Structure

Exposure to galactose oxidase of GM1 ganglioside molecular species embedded into phospholipid vesicles

Kinetics / Animals / Liposomes / Membrane Lipids / Cattle / Structure activity Relationship / Brain Chemistry / Biochemistry and cell biology / Structure activity Relationship / Brain Chemistry / Biochemistry and cell biology

Mitochondrial processing peptidases

Medical Microbiology / Mitochondria / Biological Sciences / Saccharomyces cerevisiae / Protein Structure and Function / Phylogeny / Humans / Sequence alignment / Escherichia coli / Animals / Physical sciences / Enzyme / Substrate Specificity / Amino Acid Sequence / Structure activity Relationship / Biochemistry and cell biology / Phylogeny / Humans / Sequence alignment / Escherichia coli / Animals / Physical sciences / Enzyme / Substrate Specificity / Amino Acid Sequence / Structure activity Relationship / Biochemistry and cell biology

8-(2-Furyl)adenine derivatives as A2A adenosine receptor ligands

Organic Chemistry / Humans / Structure activity Relationship / Recombinant Proteins / Adenine / Ligands / Molecular Structure / Ligands / Molecular Structure

Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells

Organic Chemistry / Prostate Cancer / Humans / Male / Organoselenium Compounds / Bioorganic and medicinal Chemistry / Cell Proliferation / Antitumor Activity / Structure activity Relationship / Carbamates / Molecular Structure / Bioorganic and medicinal Chemistry / Cell Proliferation / Antitumor Activity / Structure activity Relationship / Carbamates / Molecular Structure

Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Animals / Trypanosoma brucei / Trypanosoma brucei brucei / Trypanocidal Agents / Amino Acid Sequence / Quinolines / Structure activity Relationship / Ligands / Molecular Structure / Trypanosoma brucei brucei / Trypanocidal Agents / Amino Acid Sequence / Quinolines / Structure activity Relationship / Ligands / Molecular Structure

Structure-based design of indole propionic acids as novel PPARα/γ co-agonists

Organic Chemistry / X Rays / Propionic Acid / Drug Design / X ray diffraction / Bioorganic and medicinal Chemistry / Type 2 Diabetes Mellitus / Structure activity Relationship / Complex Structure / Nuclear hormone receptor / Molecular Structure / Bioorganic and medicinal Chemistry / Type 2 Diabetes Mellitus / Structure activity Relationship / Complex Structure / Nuclear hormone receptor / Molecular Structure

Transglutaminase 2: A molecular Swiss army knife

Medical Microbiology / Transcription Regulation / Extracellular Matrix / Biological Sciences / Humans / Animals / Cell Death / Physical sciences / Functional diversity / Gene Duplication / Subcellular Localization / Protein Conformation / Cell Proliferation / Structure activity Relationship / Cell Survival / Conformational Change / Gtp Binding Proteins / Biochemistry and cell biology / Transglutaminases / Animals / Cell Death / Physical sciences / Functional diversity / Gene Duplication / Subcellular Localization / Protein Conformation / Cell Proliferation / Structure activity Relationship / Cell Survival / Conformational Change / Gtp Binding Proteins / Biochemistry and cell biology / Transglutaminases

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