Structure activity Relationship - Page 8

Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase

Organic Chemistry / Medicinal Chemistry / Macromolecular X-Ray Crystallography / Animals / Trypanosoma brucei / Trypanosoma brucei brucei / Trypanocidal Agents / Amino Acid Sequence / Quinolines / Structure activity Relationship / Ligands / Molecular Structure / Trypanosoma brucei brucei / Trypanocidal Agents / Amino Acid Sequence / Quinolines / Structure activity Relationship / Ligands / Molecular Structure

Download

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Download

Rutoxyl [rutin/4-acetamide-1-hydroxy-2,2,6,6-tetramethylpiperidinium] is a new member of the class of semi-natural products of high pharmacological potency

Antioxidants / Animals / Natural Product / Male / Drug Design / Rats / Wistar Rats / Biochemistry and molecular biology / Structure activity Relationship / Antineoplastic Agents / Biochemistry and cell biology / Molecular Structure / Piperidines / Rats / Wistar Rats / Biochemistry and molecular biology / Structure activity Relationship / Antineoplastic Agents / Biochemistry and cell biology / Molecular Structure / Piperidines

Download

Novel benzimidazole derivatives as expected anticancer agents

Humans / Animals / Pheochromocytoma / Rats / Benzimidazoles / Structure activity Relationship / Cell Survival / Antineoplastic Agents / Molecular Structure / Structure activity Relationship / Cell Survival / Antineoplastic Agents / Molecular Structure

Download

Introdução a modelagem molecular de fármacos no curso experimental de química farmacêutica

Molecular modeling / CHEMICAL SCIENCES / Conformational Analysis / Structure activity Relationship / Quimica Nova

Download

Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi

Organic Chemistry / Treatment / Drug development / Macromolecular X-Ray Crystallography / In Vitro / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure

Download

Echinocystic acid 3,16-O-bisglycosides from Albizia procera

Phytochemistry / Egypt / Biological Sciences / Humans / CHEMICAL SCIENCES / Structure activity Relationship / Glycosides / Oleanolic acid / Molecular Structure / Triterpenes / Structure activity Relationship / Glycosides / Oleanolic acid / Molecular Structure / Triterpenes

Download

Preliminary crystal structure of Acinetobacter glutaminasificans glutaminase-asparaginase

Crystallization / Biological Chemistry / Biological Sciences / Escherichia coli / Pseudomonas / CHEMICAL SCIENCES / L-asparaginase / Vibrio / X ray diffraction / Acinetobacter / Protein Conformation / Structure activity Relationship / CHEMICAL SCIENCES / L-asparaginase / Vibrio / X ray diffraction / Acinetobacter / Protein Conformation / Structure activity Relationship

Download

A unique spacer domain of synaptotagmin IV is essential for Golgi localization

Protein Folding / Neurochemistry / Localization / Immunohistochemistry / Animals / Glycosylation / Golgi / Rats / Exocytosis / Transfection / Amino Acid Sequence / Calcium Binding Proteins / Subcellular Fractions / Structure activity Relationship / C Domain / Golgi Apparatus / Neurosciences / Glycosylation / Golgi / Rats / Exocytosis / Transfection / Amino Acid Sequence / Calcium Binding Proteins / Subcellular Fractions / Structure activity Relationship / C Domain / Golgi Apparatus / Neurosciences

Download

CKAAPs DB: a Conserved Key Amino Acid Positions DataBase

Algorithms / Relational Database / Protein Folding / Protein Engineering / Structural Stability / Biological Sciences / Environmental Sciences / Sequence alignment / Text Analysis / Animals / Gene ontology / Peptides / Nucleic Acids / Proteins / Theoretical Analysis / Enzyme / Computer User Interface Design / Information Storage and Retrieval / Secondary Structure / Protein Secondary Structure Prediction / Amino Acid Profile / Protein Conformation / Amino Acid Sequence / Structure activity Relationship / Structural Similarity Index / Internet / Protein Data Bank / Nucleic Acid / Web Interface / Biological Sciences / Environmental Sciences / Sequence alignment / Text Analysis / Animals / Gene ontology / Peptides / Nucleic Acids / Proteins / Theoretical Analysis / Enzyme / Computer User Interface Design / Information Storage and Retrieval / Secondary Structure / Protein Secondary Structure Prediction / Amino Acid Profile / Protein Conformation / Amino Acid Sequence / Structure activity Relationship / Structural Similarity Index / Internet / Protein Data Bank / Nucleic Acid / Web Interface

Download

7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 Inhibitors: A Potential Treatment for Asthma

Organic Chemistry / Animals / Phosphodiesterase Inhibitors / Pyridines / Bioorganic and medicinal Chemistry / Structure activity Relationship / Furans / Structure activity Relationship / Furans

Download

3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor

Organic Chemistry / Dogs / Mice / Animals / Kinase inhibitor / Amides / Rats / Structure activity Relationship / Physical Properties / Protein Kinase Inhibitors / Molecular Structure / aniline Compounds / Amides / Rats / Structure activity Relationship / Physical Properties / Protein Kinase Inhibitors / Molecular Structure / aniline Compounds

Download

Antimycobacterial Eudesmanolides from Inula helenium and Rudbeckia subtomentosa

Complementary and Alternative Medicine / Plant Biology / Pharmacognosy / Magnetic Resonance Spectroscopy / Structural Analysis / In Vitro / Mycobacterium tuberculosis / Sesquiterpenes / Qualitative Analysis / Isolation / Microbial Sensitivity Tests / Biological activity / Structure activity Relationship / Planta / Molecular Structure / In Vitro / Mycobacterium tuberculosis / Sesquiterpenes / Qualitative Analysis / Isolation / Microbial Sensitivity Tests / Biological activity / Structure activity Relationship / Planta / Molecular Structure

Download

Cyclotides: a natural combinatorial peptide library or a bioactive sequence player?

Cyclotides / Structure activity Relationship / Biochemistry and cell biology

Download

Biphenyl derivatives as novel dual NK1/NK2-receptor antagonists

Organic Chemistry / Humans / Animals / Conformational Analysis / Molecular Conformation / Bioorganic and medicinal Chemistry / Biological activity / Structure activity Relationship / Molecular Structure / Neurokinin receptor antagonists / Bioorganic and medicinal Chemistry / Biological activity / Structure activity Relationship / Molecular Structure / Neurokinin receptor antagonists

Download

Crystal Structure of Glycyl Endopeptidase from Carica papaya: A Cysteine Endopeptidase of Unusual Substrate Specificity

Biochemistry / Macromolecular X-Ray Crystallography / Crystal structure / Sequence alignment / Plants / Carica papaya / Substrate Specificity / Cysteine endopeptidases / Amino Acid Sequence / Structure activity Relationship / Biochemistry and cell biology / cystatin B / Cysteine Proteinase Inhibitors / Carica papaya / Substrate Specificity / Cysteine endopeptidases / Amino Acid Sequence / Structure activity Relationship / Biochemistry and cell biology / cystatin B / Cysteine Proteinase Inhibitors

Download