Structure activity Relationship

Novel IKK inhibitors: beta-carbolines

Organic Chemistry / Enzyme Inhibitors / Western blotting / Humans / HeLa cells / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bioorganic and medicinal Chemistry / Structure activity Relationship

Novel IKK inhibitors: beta-carbolines

Organic Chemistry / Enzyme Inhibitors / Western blotting / Humans / HeLa cells / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bioorganic and medicinal Chemistry / Structure activity Relationship

Structural basis for iron piracy by pathogenic Neisseria

Biochemistry / Microbiology / Electron Microscopy / Structural Biology / Molecular Dynamics Simulation / Small angle X-ray and neutron scattering / Small Angle X Ray Scattering / Intelligent Transport System / Multidisciplinary / Nature / Macromolecular X-Ray Crystallography / Crystal structure / Humans / Mice / Animals / Medical Research / Transferrin / Neisseria / Iron / Cattle / X ray diffraction / Protein Conformation / Species Specificity / Structure activity Relationship / Cell Surface Markers / Bacterial meningitis / Outer Membrane Protein / Apoproteins / Small angle X-ray and neutron scattering / Small Angle X Ray Scattering / Intelligent Transport System / Multidisciplinary / Nature / Macromolecular X-Ray Crystallography / Crystal structure / Humans / Mice / Animals / Medical Research / Transferrin / Neisseria / Iron / Cattle / X ray diffraction / Protein Conformation / Species Specificity / Structure activity Relationship / Cell Surface Markers / Bacterial meningitis / Outer Membrane Protein / Apoproteins

Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid

Organic Chemistry / Medicinal Chemistry / Epilepsy / Mice / Animals / Male / Rats / Valproic Acid / Structure activity Relationship / Male / Rats / Valproic Acid / Structure activity Relationship

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

Kinetics / Macromolecular X-Ray Crystallography / Biological Sciences / Crystal structure / Humans / Endoplasmic Reticulum / Antigen Presentation / Special functions / CHEMICAL SCIENCES / Active site / Substrate Specificity / Structure activity Relationship / Conformational Change / Antigens / MHC class I / Endoplasmic Reticulum / Antigen Presentation / Special functions / CHEMICAL SCIENCES / Active site / Substrate Specificity / Structure activity Relationship / Conformational Change / Antigens / MHC class I

Novel IKK inhibitors: beta-carbolines

Organic Chemistry / Enzyme Inhibitors / Western blotting / Humans / HeLa cells / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bioorganic and medicinal Chemistry / Structure activity Relationship

Novel IKK inhibitors: beta-carbolines

Organic Chemistry / Enzyme Inhibitors / Western blotting / Humans / HeLa cells / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bioorganic and medicinal Chemistry / Structure activity Relationship

Oximinoarylsulfonamides as potent HIV protease inhibitors

Organic Chemistry / Kinetics / HIV protease / Drug Design / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Carbamates / Bioorganic and medicinal Chemistry / Structure activity Relationship / Carbamates

Discovery of ectoparasiticidal hydrazonotrifluoromethanesulfonanilides

Organic Chemistry / Drug Discovery / Cats / Dogs / Animals / Hydrazones / Bioorganic and medicinal Chemistry / Structure activity Relationship / Rhipicephalus sanguineus / Hydrazones / Bioorganic and medicinal Chemistry / Structure activity Relationship / Rhipicephalus sanguineus

Novel IKK inhibitors: beta-carbolines

Organic Chemistry / Enzyme Inhibitors / Western blotting / Humans / HeLa cells / Bioorganic and medicinal Chemistry / Structure activity Relationship / Bioorganic and medicinal Chemistry / Structure activity Relationship

Structure-based design of indole propionic acids as novel PPARα/γ co-agonists

Organic Chemistry / X Rays / Propionic Acid / Drug Design / Nuclear Hormone Receptors / X ray diffraction / PPAR / Bioorganic and medicinal Chemistry / Type 2 Diabetes Mellitus / Structure activity Relationship / Complex Structure / Nuclear hormone receptor / Molecular Structure / X ray diffraction / PPAR / Bioorganic and medicinal Chemistry / Type 2 Diabetes Mellitus / Structure activity Relationship / Complex Structure / Nuclear hormone receptor / Molecular Structure

Spirocyclopropyl pyrrolidines as a new series of α-l-fucosidase inhibitors

Organic Chemistry / Titanium / Enzyme Inhibitors / Kidney / Animals / Cattle / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Cattle / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship

Efficient parallel synthesis of macrocyclic peptidomimetics

Organic Chemistry / Pharmaceutical Chemistry / Silver / Peptides / Cyclic peptides / Molecular Mimicry / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Dimerization / Molecular Mimicry / Molecular Conformation / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Dimerization

Structural and Functional Evidence for Bacillus subtilis PaiA as a Novel N1-Spermidine/Spermine Acetyltransferase

Catalysis / Kinetics / Biological Chemistry / Macromolecular X-Ray Crystallography / Polyamines / Biological Sciences / Escherichia coli / Biological / CHEMICAL SCIENCES / Oxygen / Bacillus subtilis / Protein Conformation / Amino Acid Sequence / Structure activity Relationship / Protein Binding / Cations / Dimerization / Molecular Sequence Data / Biological Sciences / Escherichia coli / Biological / CHEMICAL SCIENCES / Oxygen / Bacillus subtilis / Protein Conformation / Amino Acid Sequence / Structure activity Relationship / Protein Binding / Cations / Dimerization / Molecular Sequence Data

4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives

Organic Chemistry / Mice / Animals / Urea / Rats / Water soluble polymers / Structure activity Relationship / Tetrazoles / Water soluble polymers / Structure activity Relationship / Tetrazoles

Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase

Organic Chemistry / Enzyme Inhibitors / Humans / Mice / Blood Pressure / Animals / Male / Drug Design / Solubility / Time Factors / Functional Group / Bioorganic and medicinal Chemistry / Structure activity Relationship / Adamantane / Physical Properties / Molecular Structure / Animals / Male / Drug Design / Solubility / Time Factors / Functional Group / Bioorganic and medicinal Chemistry / Structure activity Relationship / Adamantane / Physical Properties / Molecular Structure

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