A new access to quinazolines from simple anilines

2007

Fused pyrimidine derivatives R 0515 A New Access to Quinazolines from Simple Anilines. — A variety of novel substiquinazolines is prepared starting from the corresponding anilines. The method in15- 144 tuted cludes the N-ethoxycarbonyl protection, further treatment with urotropin (IV) in TFA, followed by the addition of K3Fe(CN)6 in aqueous ethanolic KOH. para-Substituted N-ethoxycarbonyl anilines show very low or no activity. — (CHILIN*, A.; MARZARO, G.; ZANATTA, S.; BARBIERI, V.; PASTORINI, G.; MANZINI, P.; GUIOTTO, A.; Tetrahedron 62 (2006) 52, 12351-12356; Dip. Sci. Farm., Univ. Padova, I-35131 Padova, Italy; Eng.) — Y. Steudel