ChemInform Abstract: Novel Design Principle Validated: Glucopyranosylidene-spiro-oxathiazole as New Nanomolar Inhibitor of Glycogen Phosphorylase, Potential Antidiabetic Agent

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Carbohydrates U 0500 Novel Design Principle Validated: Glucopyranosylidene-spiro-oxathiazole as New Inhibitor of Glycogen Phosphorylase, Potential Antidiabetic Agent. 09- 204 Nanomolar — The 5-naphthyl substituted title compound (Vd), obtained following a novel design principle, is a potent glucose-based inhibitor of glycogen phosphorylase with an inhibition in the nanomolecular range. — (SOMSAK*, L.; NAGY, V.; VIDAL, S.; CZIFRAK, K.; BERZSENYI, E.; PRALY, J.-P.; Bioorg. Med. Chem. Lett. 18 (2008) 20, 5680-5683; Dep. Org. Chem., Univ. Debrecen, H-4010 Debrecen, Hung.; Eng.) — A. Forchert

ChemInform 2009, 40, issue 09

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