Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors

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2005 Peptides U 0400

52- 163

Diprolyl Nitriles as Potent Dipeptidyl Peptidase IV Inhibitors. — The synthesis and structure—activity relationships of a series of substituted diprolyl nitriles leading to the identification of compound (Ia) as a highly potent inhibitor of pipeptidyl peptidase IV are reported. — (ZHAO*, G.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 18, 3992-3995; Dep. Discovery Chem., Bristol-Myers Squibb Pharm. Res. Inst., Princeton, NJ 08543, USA; Eng.) — H. Toeppel

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