0DQXVFULSW &OLFNKHUHWRGRZQORDG0DQXVFULSW 0DQXVFULSWB+LJKOLJKWGRF[ &OLFNKHUHWRYLHZOLQNHG5HIHUHQFHV 1 1 ! 2 3 4 Marcello Moccia 1, Sabina Pappatà 2*, Marina Picillo3, Roberto Erro4-5, Anna Rita Daniela Coda 2, 5 6 Katia Longo6, Carmine Vitale6-7, Marianna Amboni6, Arturo Brunetti2,8, Giuseppe Capo9, Marco 7 8 9 Salvatore2,8, Paolo Barone3, Maria Teresa Pellecchia 3. 10 11 12 13 14 Dopamine transporter availability 15 16 17 in motor subtypes of de novo drug-QDwYH3DUNLQVRQ¶VGLVHDVH 18 19 20 21 22 1. Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples 23 24 Federico II, Naples, Italy 25 26 27 2. Institute of Biostructure and Bioimaging, Naples, Italy 28 29 3. Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, Department of Medicine, 30 31 University of Salerno, Italy 32 33 34 4. Sobell Department of Motor Neuroscience and Movement Disorders, University College London 35 36 (UCL) Institute of Neurology, London, United Kingdom 37 38 39 5. Department of Neurological and Movement Sciences. University of Verona, Policlinico Borgo Roma, 40 41 Verona, Italy 42 43 44 6. IDC Hermitage Capodimonte, Naples, Italy 45 46 7. Department of Motor Sciences, University Parthenope, Naples, Italy 47 48 8. Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy 49 50 51 9. AOU San Giovanni di Dio e Ruggi d¶Aragona, Salerno, Italy 52 53 54 55 56 * Correspondence to: Sabina Pappatà 57 58 Institute of Biostructure and Bioimaging 59 60 61 Via T. De Amicis, 95 62 63 64 65
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A BST R A C T . Tremor dominant (TD) and akinetic-rigid type (ART) are two motor subtypes RI3DUNLQVRQ¶VGLVHDVH associated with different disease progression and neurochemical/ neuropathological features. The role of presynaptic nigrostriatal dopaminergic damage is still controversial, poorly explored and only assessed in medicated patients. In this study we investigated with FP-CIT SPECT the striatal dopamine transporter (DAT) availability in drug-naïve PD patients with ART and TD phenotypes. Fifty-one de novo, drug-naïve patients with PD underwent FP-CIT SPECT studies. Patients were evaluaWHGZLWK8QLILHG3DUNLQVRQ¶V'LVHDVH5DWLQJ6FDOH 83'56 SDUW,,,DQG+RHKQDQG
