Infective Endocarditis Epidemiology Over Five Decades: A Systematic Review
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Infective Endocarditis Epidemiology Over Five Decades: A Systematic Review Leandro Slipczuk1,2, J. Nicolas Codolosa3, Carlos D. Davila1, Abel Romero-Corral3, Jeong Yun1,4, Gregg S. Pressman3, Vincent M. Figueredo3,5* 1 Department of Medicine, Einstein Medical Center, Philadelphia, Pennsylvania, United States of America, 2 Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, 3 Einstein Institute for Heart and Vascular Health, Einstein Medical Center, Philadelphia, Pennsylvania, United States of America, 4 Pulmonary and Critical Care Medicine Division, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America, 5 Jefferson Medical College, Philadelphia, Pennsylvania, United States of America
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Abstract Aims: To Assess changes in infective endocarditis (IE) epidemiology over the last 5 decades. Methods and Results: We searched the published literature using PubMed, MEDLINE, and EMBASE from inception until December 2011. Data From: Einstein Medical Center, Philadelphia, PA were also included. Criteria for inclusion in this systematic review included studies with reported IE microbiology, IE definition, description of population studied, and time frame. Two authors independently extracted data and assessed manuscript quality. One hundred sixty studies (27,083 patients) met inclusion criteria. Among hospital-based studies (n=142; 23,606 patients) staphylococcal IE percentage increased over time, with coagulase-negative staphylococcus (CNS) increasing over each of the last 5 decades (p