Local control of rhino-orbito-cerebral mucormycosis dramatically impacts survival

RESEARCH NOTE

Local control of rhino-orbito-cerebral mucormycosis dramatically impacts survival

P. Vironneau1, R. Kania1, G. Morizot2, C. Elie3, D. Garcia-Hermoso2,5, P. Herman1, O. Lortholary2,4,5, F. Lanternier2,4 and the French Mycosis Study Group* 1) Service d’Oto-Rhino-Laryngologie, H^opital Lariboisiere, APHP, Universite Paris 7, 2) Centre National de Reference Mycoses Invasives et Antifongiques, Institut Pasteur, 3) Service de Biostatistique, H^opital Necker-Enfants Malades, Universite Paris Descartes, APHP, 4) Service des Maladies Infectieuses et Tropicales, Institut Imagine, H^opital Necker-Enfants Malades, Universite Paris-Descartes, APHP, Centre d’Infectiologie Necker-Pasteur and 5) CNRS URA3012, Unite de Mycologie Moleculaire, Institut Pasteur, Paris, France

Abstract Surgery and antifungals are the reference standard for rhinoorbito-cerebral mucormycosis (ROCM) treatment. The impact of local control on survival of 22 consecutive ROCM adults was studied on day 90: none vs. 75% died, respectively, with or without local control (p