Novel Types of Carborane‐Carrier Hyaluronan Derivatives via “Click Chemistry”

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Copyright WILEY-VCH Verlag GmbH & Co. KGaA, 69469 Weinheim, Germany, 2008. Supporting Information for Macromol. Biosci., 2008, 8, 670.

Novel Types of Carborane-Carrier Hyaluronan Derivatives via “Click Chemistry”

Chiara Di Meo, Luigi Panza, Federica Campo, Donatella Capitani, Luisa Mannina, Alessandra Banzato, Maria Rondina, Antonio Rosato and Vittorio Crescenzi

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8a

11’ 1’ 8’

2a 6a

13’

7’

6a’ 4a

3’,4’,5’,6’

2b 3b 5b 4b 5a 2’ 3a

1a 1b 9’

Figure 1S. 2D 1H-13C HSQC map of HAAACB in phosphate buffered D2O solution at 27°C. The full assignment is also reported. The 1H and the 13C NMR spectra are reported as projections in the f2 and f1 dimension, respectively

2

8a

1’’ 5’’

4’’

2a

7’’

6a 6a’ 4a 3b 2b 5b 4b 5a 3a

1a 1b 3’’

Figure 2S. 2D 1H-13C HSQC map of HApACB in phosphate buffered D2O solution at 27°C. The full assignment is also reported. The 1H and the 13C NMR spectra are reported as projections in the f2 and f1 dimension, respectively.

3

3b

OH O

6a

4a HO

HO

2a

5a

O NH

3a

1a

4b O

OH 1b

5b

O

2b

6b

O

O- Na+

COCH 3

7a 8a

8a

2a 6a 6a’ 4a 5b 4b

3b

2b 5a

3a 1a 1b

Figure 3S. Up: Scheme of HA repetitive unit, along with labels used in NMR assignments. Down: 2D 1H-13C HSQC map of HA in D2O at 27°C. The full assignment is also reported. The 1H spectrum is reported as projection in the f2 dimension.

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