PANDA: The PORTO-Associated Neurodevelopmental Assessment Study

PANDA

The PORTO-Associated Neurodevelopmental Assessment Study Levine, T. A.*1 and Pinnamaneni, R.,*2 Alderdice, F. A.,1 McAuliffe, F. M.,3 Grunau, R. E.,4 Foran, A.2 1Queen’s

University Belfast School of Nursing and Midwifery; 2Department of Neonatology, Rotunda Hospital and Children’s University Hospital, Temple Street; 3Department of Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital; 4Department of Pediatrics, University of British Columbia, and Child and Family Research Institute, Vancouver, Canada

Background:

ABSTRACT

There is a lack of consensus about whether children born following intrauterine growth restriction (IUGR) defined by abnormal umbilical artery pulsatility index are at additional risk of early childhood developmental delays compared to children born small for gestational age (SGA) with normal Doppler ultrasound findings.

Objective: To determine whether IUGR children differ from SGA children in neurodevelopment, psychosocial development, visual-motor integration, or anthropometric development.

Methods:

Participants were recruited from the PORTO cohort. Children (n= 379) were assessed at 3 years using the Ages and Stages Questionnaire (n= 365), the Bayley Scales of Infant and Toddler Development, III (n= 207), the Pediatric Quality of Life Inventory (n= 166), the Child Behavior Checklist (n= 166), and the Beery-Buktenica Developmental Test of Visual-Motor Integration (n= 190). Anthropometric measurements were available for 186 children.

Results:

IUGR children demonstrated poorer neurodevelopment on the ASQ and Bayley-III, poorer health-related quality of life on the PedsQL, more behavioural problems on the CBCL, and difficulties in visual-motor integration on the Beery VMI. There were no significant differences between the groups in height, weight, or head circumference.

SUMMARY OF FINDINGS Neurodevelopment in SGA and IUGR Children SGA Mean (SD) ASQ Communication 54.2 (10.8) Gross Motor 54.2 (10.8) Fine Motor 48.5 (13.4) Problem Solving 55.6 (7.6) Bayley-III Scaled Scores Cognitive 10.6 (2.3) Language 23.0 (4.2) Receptive 12.1 (2.3) Expressive 10.9 (2.5) Motor 23.1 (4.8) Fine 11.9 (2.5) Gross 11.1 (3.2)

INTRODUCTION

IUGR is a significant reduction in fetal growth rate that inhibits an infant from reaching his or her standard growth potential, resulting in birthweight