Recovery of erythrocyte Na(+)-K(+)-Cl- cotransport activity by enalapril RA Sanchez, MI Gimenez, BH Gilbert, C Giannone, EJ Marco and AJ Ramirez Hypertension 1991, 17:334-339 Hypertension is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX 72514 Copyright © 1991 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online ISSN: 1524-4563
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Recovery of Erythrocyte Na+-K+-Cl Cotransport Activity by Enalapril Ramiro A. Sanchez, Maria I. Gimenez, Bernardo H. Gilbert, Carlos Giannone, Enrique J. Marco, and Agustin J. Ramirez
We studied total exchangeable sodium, ion transport activity at maximal rate, and erythrocyte Na + content in response to angiotensin converting enzyme inhibition in mild-to-moderate essential hypertensive patients with normal renal function. Twenty-five patients (mean age 56 years, range 40-62 years) who had abnormal red blood cell Na+-K+-Cl~ cotransport or red blood cell Li+-Na+ countertransport were treated with either enalapril (20 mg daily) or hydrochlorothiazide (50 mg daily) during a 30 -day period. During the period of enalapril treatment, Na+-K+ pump and Na+-K+-Cl" cotransport increased significantly from 4,282±255 to 5,236±325 /tmol/1 red blood cell/hr (;>
