Serum gamma glutamyl transferase: a novel biomarker for screening of premature coronary artery disease

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in the cardiac cycle in terms of retinal vessel diameter, therefore ECG gated retinal photography should be synchronized to mid systole to eliminate the pulsatile changes due to the cardiac cycle and improve the precision of the technique. doi:10.1016/j.hlc.2010.06.745 79 Recent Trends in Percutaenous Coronary Intervention Practise in Victorian Public Hospitals: Insights from the Melbourne Interventional Group Registry B. Yan 1,3,∗ , A. Ajani 2,3 , N. Andrianopoulos 3 , S. Duffy 4 , D. Clark 5 , A. Brennan 3 , P. Loane 3 , M. Sebastian 6 , G. New 7 , R. Lew 8 , C. Reid 3 1 Chinese

University of Hong Kong, Hong Kong Melbourne Hospital, Melbourne, Australia 3 Monash University, Melbourne, Australia 4 Alfred Hospital, Melbourne, Australia 5 Austin Hospital, Melbourne, Australia 6 Geelong Hospital, Melbourne, Australia 7 Box Hill Hospital, Melbourne, Australia 8 Frankston Hospital, Melbourne, Australia 2 Royal

Background: Little is known about the trends in Australian percutaneous coronary intervention (PCI) practise in the era of drug-eluting stents (DES) and prolonged dual-antiplatelet therapy. Methods: We analysed 9204 consecutive patients who underwent PCI (April ‘04 to March ‘08) from the Melbourne Interventional Group Registry. Temporal trends in baseline characteristics, in-hospital and 12-month outcomes from year to year were compared. Results: Between 2004 and 2008, the age of patients undergoing PCI was stable (mean 65 ± 12). Co-morbidities such as diabetes, hypertension, hyperlipidaemia, peripheral arterial disease and stroke increased steadily (p < 0.01). There were less elective and more urgent PCI, especially for myocardial infarction 70% occlusion) patients and 107 healthy control were recruited. Atherosclerotic CAD were angiographically diagnosed and serum GGT, cholesterol and triglyceride were analyzed. Patients were predominantly male (96%) with mean (SD) age of 38.7 (4.3) years. The main risk factors identified in the CAD patients were hypertension 71%, dyslipidemia 69%, smoking 68% and diabetes 30%. The patients had significantly increased oxidative stress with median GGT 53 U/L (IQR 42-69) as compared to controls 28 IU/L (IQR 21-33; p = 0.001). Serum GGT exhibited a significant positive correlation with blood pressure (r = 0.53), cholesterol (r = 0.38), blood glucose (r = 0.41), smoking (r = 0.19) and negative correlation with total antioxidant status (r = −0.48; p < 0.01). Area under the receiver operative curve of GTT was 0.929 (95% CI: 0.896–0.962). The study revealed good diagnostic accuracy at cut off 35 U/L for CAD in high risk young patients with sensitivity 92%, specificity 81%, positive likelihood ratio 4.6, negative likelihood ratio 0.1 and diagnostic odd ratio of 48. The increase in serum GGT, a marker of oxidative stress is associated with premature coronary artery disease in non-alcohol consuming patients of Pakistani origin. Estimation of GGT is an accurate and cost effective test for screening of the high risk CAD young patients before angiography in developing countries. doi:10.1016/j.hlc.2010.06.747 81 Survivors of Out of Hospital Cardiac Arrests Proceeding to Coronary Angiogram: Clinical, Angiographic Features and In-Hospital Outcomes—A Single Centre Experience V. Wijesekera ∗ , D. Mullany, M. Savage, D. Walters The Prince Charles Hospital, Brisbane, Australia Background: Out of hospital cardiac arrest (OOHCA) is an important cause of mortality in Australia with acute myocardial infarction (AMI) being a leading cause. Methods: We reviewed a prospective database of patients with a diagnosis of OOHCA who underwent

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Heart, Lung and Circulation 2010;19S:S1–S268

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