SYNTHETIC CURCUMIN INHIBITS CARRAGEENAN-INDUCED PAW EDEMA IN RATS

August 23, 2017 | Autor: Wisut Wichitnithad | Categoria: Low Dose, Turmeric, Anti Inflammatory Activity, Active Ingredient, Prostaglandin E2
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SYNTHETIC CURCUMIN INHIBITS CARRAGEENAN-INDUCED PAW EDEMA IN RATS Warawanna Buadonpri1, Wisut Wichitnithad2, Pornchai Rojsitthisak2 and Pasarapa Towiwat1,∗ 1Department

of Pharmacology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330 Thailand 2Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330 Thailand ABSTRACT: Curcumin is the main active ingredient in Curcuma longa L. (Turmeric) and exhibits potent antioxidative and anti-inflammatory activities. In this study, the antiinflammatory activity of curcumin was evaluated in a carrageenan-induced rat paw edema test and compared with that of indomethacin. Rats treated with indomethacin (10 mg/kg, p.o.) and curcumin (25, 50, 100, 200 and 400 mg/kg, p.o.) showed a significant reduction in carrageenan-induced paw edema (p
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