Tissue factor and its natural inhibitor in pre-eclampsia and SGA

NIH Public Access Author Manuscript J Matern Fetal Neonatal Med. Author manuscript; available in PMC 2011 September 12.

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Published in final edited form as: J Matern Fetal Neonatal Med. 2008 December ; 21(12): 855–869. doi:10.1080/14767050802361872.

Tissue Factor and Its Natural Inhibitor in Preeclampsia and SGA Offer Erez1,2, Roberto Romero1,3, Debra Hoppensteadt4, Nandor Gabor Than1, Jawed Fareed4, Shali Mazaki-Tovi1,2, Jimmy Espinoza1,2, Tinnakorn Chaiworapongsa1,2, Sung-Su Kim1, Bo Hyun Yoon5, Sonia S. Hassan1,2, Francesca Gotsch1, Lara Friel1,2, Edi Vaisbuch1,2, and Juan Pedro Kusanovic1,2 1Perinatology Research Branch, NICHD, NIH, DHHS, Detroit, Michigan, USA 2Department

of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA

3Center

for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, USA

4Loyola

University Medical Center, Department of Pathology, Maywood, Illinois, USA

5Seoul

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National University College of Medicine, Department of Obstetrics and Gynecology, Seoul, South Korea

Abstract Objective—Tissue factor (TF), the major activator of the extrinsic pathway of coagulation, is abundant in the placenta and decidua. The aim of this study was to determine the maternal plasma concentrations of TF and its primary inhibitor, tissue factor pathway inhibitor (TFPI), in women who delivered small for gestational age (SGA) neonates, and in preeclampsia. Study Design—A cross-sectional study included the following groups: 1) women with normal pregnancies (n=86); 2) patients who delivered SGA neonates (n=61); and 3) women with preeclampsia (n=133). Maternal plasma concentrations of TF and TFPI were measured by a sensitive immunoassay. Non-parametric statistics were used for analysis.

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Results—1)Women with preeclampsia had a significantly higher median plasma concentration of TF than patients with a normal pregnancy (median: 1187 pg/ml; range: 69–11675 vs. median: 291.5 pg/ml; range: 6.3–2662.2; p