Chemical Synthesis - Page 3

Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors

Organic Chemistry / Cancer / Levels of selection / Signal Transduction / Cell line / In Vitro / Humans / Amines / Caspase / Akt / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Selectivity / Piperidines / In Vitro / Humans / Amines / Caspase / Akt / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Selectivity / Piperidines

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Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

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Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

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Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

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Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi

Organic Chemistry / Treatment / Drug development / Macromolecular X-Ray Crystallography / In Vitro / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure / Animals / Naphthoquinones / Chagas disease / European / Hydrogen Bonding / Trypanosoma Cruzi / Trypanocidal Agents / Triazoles / Structure activity Relationship / Cations / Chemical Synthesis / Molecular Structure

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Phosphoramidate Dinucleosides as Hepatitis C Virus Polymerase Inhibitors

Organic Chemistry / Medicinal Chemistry / Modeling / Enzyme Inhibitors / Magnetic Resonance Spectroscopy / In Vitro / Humans / Virus / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Molecular Model / Nucleosides / Chemical Synthesis / Oxidation-Reduction / In Vitro / Humans / Virus / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Molecular Model / Nucleosides / Chemical Synthesis / Oxidation-Reduction

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Phosphoramidate Dinucleosides as Hepatitis C Virus Polymerase Inhibitors

Organic Chemistry / Medicinal Chemistry / Modeling / Enzyme Inhibitors / Magnetic Resonance Spectroscopy / In Vitro / Humans / Virus / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Molecular Model / Nucleosides / Chemical Synthesis / Oxidation-Reduction / In Vitro / Humans / Virus / Hepatitis C Virus / Organophosphorus Compounds / Medicinal / Molecular Model / Nucleosides / Chemical Synthesis / Oxidation-Reduction

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Synthesis of 1-β-D-(5-Deoxy-5-iodoarabinofuranosyl)-2-nitroimidazole (β-IAZA): A Novel Marker of Tissue Hypoxia

Hypoxia / Nucleic Acids / Chemical Synthesis

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Synthesis of orthogonally protected d-olivoside, 1,3-di-O-acetyl-4-O-benzyl-2,6-dideoxy-d-arabinopyranose, as a C-glycosyl donor

Organic Chemistry / Copper / Zinc / X ray diffraction / Tetrahedron / Acetic Acid / Chemical Synthesis / Acetic Acid / Chemical Synthesis

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Low temperature aqueous chemical synthesis of CdS sensitized ZnO nanorods

Engineering / Scanning Electron Microscopy / PHOTOELECTRON SPECTROSCOPY / Zinc Oxide / CHEMICAL SCIENCES / X ray diffraction / Chemical bath deposition / Low Temperature / Field Emission Scanning Electron Microscopy / X Ray Photoelectron Spectroscopy / Chemical Synthesis / X ray diffraction / Chemical bath deposition / Low Temperature / Field Emission Scanning Electron Microscopy / X Ray Photoelectron Spectroscopy / Chemical Synthesis

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Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1

Organic Chemistry / Modeling / Prediction / Pharmacokinetics / Molecular modeling / Cercopithecus aethiops / Cell line / In Vitro / Humans / Animals / Resonant Energy Transfer / Bioluminescence / In Vivo / Rats / Molecular Model / Water Solubility / Acetic Acid / ADME / Bioorganic and medicinal Chemistry / Thiazoles / In Silico / Structure activity Relationship / Protein Binding / Chemical Synthesis / Selectivity / Binding affinity / Cercopithecus aethiops / Cell line / In Vitro / Humans / Animals / Resonant Energy Transfer / Bioluminescence / In Vivo / Rats / Molecular Model / Water Solubility / Acetic Acid / ADME / Bioorganic and medicinal Chemistry / Thiazoles / In Silico / Structure activity Relationship / Protein Binding / Chemical Synthesis / Selectivity / Binding affinity

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Tri-partite complex for axonal transport drug delivery achieves pharmacological effect

Cognitive Science / Pain / Targeted Drug Delivery / Drug delivery / Nanoparticles / Polymers / Cell line / wheat germ agglutinin (WGA) / Amines / Animals / Phage display / Central Nervous System / Drug Delivery Systems / Neurons / Shell Half-Life / Rats / Macaca fascicularis / Side Effect / Rabbits / Nerve Growth Factor / Chemical Synthesis / Effective Dose / Neurosciences / Analgesics / Gamma-Aminobutyric Acid / Biochemistry and cell biology / Polymers / Cell line / wheat germ agglutinin (WGA) / Amines / Animals / Phage display / Central Nervous System / Drug Delivery Systems / Neurons / Shell Half-Life / Rats / Macaca fascicularis / Side Effect / Rabbits / Nerve Growth Factor / Chemical Synthesis / Effective Dose / Neurosciences / Analgesics / Gamma-Aminobutyric Acid / Biochemistry and cell biology

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Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors

Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Homocysteine / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis

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Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors

Organic Chemistry / Enzyme Inhibitors / In Vitro / Humans / Homocysteine / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Enzyme / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis

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A stereo-divergent route to aminocyclopentitol derivatives

Organic Chemistry / Asymmetric Synthesis / Metathesis / Chemical Synthesis

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A stereo-divergent route to aminocyclopentitol derivatives

Organic Chemistry / Asymmetric Synthesis / Metathesis / Chemical Synthesis

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