Drug Discovery

Ayurveda and natural products drug discovery

Ayurveda / Drug Discovery / Current Science / Natural Product

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Lysyl Oxidase is Essential for Hypoxia-Induced Metastasis

Pharmacology / Biochemistry / Bioinformatics / Evolutionary Biology / Genetics / Marine Biology / Neuroscience / Environmental Science / Geophysics / Physics / Materials Science / Quantum Physics / Developmental Biology / Immunology / Climate Change / Molecular Biology / Structural Biology / Genomics / RNA / Computational Biology / Transcriptomics / Biotechnology / Systems Biology / Cancer / Breast Cancer / Biology / Metabolomics / Cell Cycle / Proteomics / Ecology / Drug Discovery / Evolution / Hypoxia / Nanotechnology / Astrophysics / Neurobiology / Medicine / Multidisciplinary / Palaeobiology / Functional Genomics / Nature / Signal Transduction / Astronomy / DNA / Head and Neck / Humans / Mice / Female / Animals / Cell Signalling / Medical Research / Survival Rate / Neoplasms / Disease Progression / Earth Science / Overall Survival / Focal Adhesion Kinase / lysyl oxidase / Marine Biology / Neuroscience / Environmental Science / Geophysics / Physics / Materials Science / Quantum Physics / Developmental Biology / Immunology / Climate Change / Molecular Biology / Structural Biology / Genomics / RNA / Computational Biology / Transcriptomics / Biotechnology / Systems Biology / Cancer / Breast Cancer / Biology / Metabolomics / Cell Cycle / Proteomics / Ecology / Drug Discovery / Evolution / Hypoxia / Nanotechnology / Astrophysics / Neurobiology / Medicine / Multidisciplinary / Palaeobiology / Functional Genomics / Nature / Signal Transduction / Astronomy / DNA / Head and Neck / Humans / Mice / Female / Animals / Cell Signalling / Medical Research / Survival Rate / Neoplasms / Disease Progression / Earth Science / Overall Survival / Focal Adhesion Kinase / lysyl oxidase

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Lysyl oxidase is essential for hypoxia-induced metastasis

Pharmacology / Biochemistry / Bioinformatics / Evolutionary Biology / Genetics / Marine Biology / Neuroscience / Environmental Science / Geophysics / Physics / Materials Science / Quantum Physics / Developmental Biology / Immunology / Climate Change / Molecular Biology / Structural Biology / Genomics / RNA / Computational Biology / Transcriptomics / Biotechnology / Systems Biology / Cancer / Breast Cancer / Biology / Metabolomics / Cell Cycle / Proteomics / Ecology / Drug Discovery / Evolution / Hypoxia / Nanotechnology / Astrophysics / Neurobiology / Medicine / Multidisciplinary / Palaeobiology / Functional Genomics / Nature / Signal Transduction / Astronomy / DNA / Head and Neck / Humans / Mice / Female / Animals / Cell Signalling / Medical Research / Survival Rate / Neoplasms / Disease Progression / Earth Science / Overall Survival / Focal Adhesion Kinase / lysyl oxidase / Marine Biology / Neuroscience / Environmental Science / Geophysics / Physics / Materials Science / Quantum Physics / Developmental Biology / Immunology / Climate Change / Molecular Biology / Structural Biology / Genomics / RNA / Computational Biology / Transcriptomics / Biotechnology / Systems Biology / Cancer / Breast Cancer / Biology / Metabolomics / Cell Cycle / Proteomics / Ecology / Drug Discovery / Evolution / Hypoxia / Nanotechnology / Astrophysics / Neurobiology / Medicine / Multidisciplinary / Palaeobiology / Functional Genomics / Nature / Signal Transduction / Astronomy / DNA / Head and Neck / Humans / Mice / Female / Animals / Cell Signalling / Medical Research / Survival Rate / Neoplasms / Disease Progression / Earth Science / Overall Survival / Focal Adhesion Kinase / lysyl oxidase

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The Drug Discovery Portal: a resource to enhance drug discovery from academia

Research Design / Drug Discovery / Pharmaceutical Chemistry / Scotland / Drug Design / Drug Delivery Systems / Universities / Drug Industry / Cooperative Behavior / Drug Delivery Systems / Universities / Drug Industry / Cooperative Behavior

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Discovery of a new series of [1,2,4]triazolo[4,3-a]quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors

Organic Chemistry / Drug Discovery / Animals / Male / Phosphodiesterase Inhibitors / Rats / Wistar Rats / Molecular Structure / Rats / Wistar Rats / Molecular Structure

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Embryonic stem cell-derived neurons are a novel, highly sensitive tissue culture platform for botulinum research

Genetics / Human Embryonic Stem Cells / Neurogenesis / Calcium / Drug Discovery / Cell Culture / Cell line / Glutamate / Tissue culture / Mice / Animals / Embryonic Stem Cell / Plant tissue Culture Techniques / Potassium / Embryonic Stem Cells / Neurons / SYNAPSES / Model System / Exocytosis / Glutamic Acid / Protein Biosynthesis / Biochemistry and cell biology / ES cell / Cell Culture / Cell line / Glutamate / Tissue culture / Mice / Animals / Embryonic Stem Cell / Plant tissue Culture Techniques / Potassium / Embryonic Stem Cells / Neurons / SYNAPSES / Model System / Exocytosis / Glutamic Acid / Protein Biosynthesis / Biochemistry and cell biology / ES cell

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Schistosomiasis control: praziquantel forever?

Drug Discovery / Biological Sciences / Humans / Resistance / Schistosomiasis / Animals / Drug Resistance / Schistosoma Mansoni / Praziquantel / Animals / Drug Resistance / Schistosoma Mansoni / Praziquantel

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Desenvolvimento do algoritmo de classificação hierárquica (Winclus) e aplicação à série de derivados indol-2-carboxilato

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GAMESS As a Free Quantum-Mechanical Platform for Drug Research

Computational Biology / Quantum Theory / Drug Discovery / Software / Drug Design / Protein Binding / Ligands / Protein Binding / Ligands

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Combined Na(+)/Ca(2+) exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function

Cardiology / Drug Discovery / Electrocardiography / Dogs / Animals / Cardiac Arrhythmias / Action Potentials / Heart Ventricles / aniline Compounds / Cardiac Arrhythmias / Action Potentials / Heart Ventricles / aniline Compounds

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Cytomics: A multiparametric, dynamic approach to cell research

Toxicology / Kinetics / Flow Cytometry / Fluorescence Microscopy / Drug Discovery / Cell Biology / Risk assessment / Stem Cell / Single molecule / Quantitative analysis / Humans / Laser Capture Microdissection / Microdissection / Animals / Laboratory Animals / Real Time / Single Cell / Xenobiotics / In Vitro Toxicology / Clinical Study / Confocal Laser Scanning Microscopy / Risk Assessment / Quantitative Analysis / Toxicity Testing / Cellular system / Cell Biology / Risk assessment / Stem Cell / Single molecule / Quantitative analysis / Humans / Laser Capture Microdissection / Microdissection / Animals / Laboratory Animals / Real Time / Single Cell / Xenobiotics / In Vitro Toxicology / Clinical Study / Confocal Laser Scanning Microscopy / Risk Assessment / Quantitative Analysis / Toxicity Testing / Cellular system

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Conserved Fungal Genes as Potential Targets for Broad-Spectrum Antifungal Drug Discovery

Computational Biology / Drug Discovery / Biological Sciences / Drug Design / Candida albicans / Spectrum / Antifungal Agents / Microbial Sensitivity Tests / Base Sequence / Eukaryotic Cell / Spectrum / Antifungal Agents / Microbial Sensitivity Tests / Base Sequence / Eukaryotic Cell

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Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression

Psychology / Stem Cells / Neuropharmacology / Drug Discovery / Gene expression / Cell Culture / Amyotrophic Lateral Sclerosis / Phytotherapy / Glutamate / Humans / Mice / Animals / Natural Product / Astrocyte / Central Nervous System / Animal Model / Alkaloids / Astrocytes / Harmine / Neurosciences / Glutamic Acid / Glutamate Transporter / Cell Culture / Amyotrophic Lateral Sclerosis / Phytotherapy / Glutamate / Humans / Mice / Animals / Natural Product / Astrocyte / Central Nervous System / Animal Model / Alkaloids / Astrocytes / Harmine / Neurosciences / Glutamic Acid / Glutamate Transporter

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Recombinant Environmental Libraries Provide Access to Microbial Diversity for Drug Discovery from Natural Products

Genetics / Drug Discovery / Microbial diversity / Multidisciplinary / Streptomyces / Escherichia coli / Applied / Applied Environmental Microbiology / Natural Product / Bacteria / Polymerase Chain Reaction / Soil Microbiology / High Pressure Liquid Chromatography / Molecular cloning / Anti-Bacterial Agents / Liquid Chromatography / Multienzyme complexes / Genetic Recombination / Genetic variation / Microbial Diversity / Biological activity / Amino Acid Sequence / Escherichia coli / Applied / Applied Environmental Microbiology / Natural Product / Bacteria / Polymerase Chain Reaction / Soil Microbiology / High Pressure Liquid Chromatography / Molecular cloning / Anti-Bacterial Agents / Liquid Chromatography / Multienzyme complexes / Genetic Recombination / Genetic variation / Microbial Diversity / Biological activity / Amino Acid Sequence

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Cyclotides, a Novel Ultrastable Polypeptide Scaffold for Drug Discovery

Drug Discovery / Macromolecular X-Ray Crystallography / Protein Stability / Genetic Engineering / Humans / Animals / Cyclotides / Protein Conformation / Amino Acid Sequence / Drug Stability / Antineoplastic Agents / Animals / Cyclotides / Protein Conformation / Amino Acid Sequence / Drug Stability / Antineoplastic Agents

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A Novel Natural Product Compound Enhances cAMP-Regulated Chloride Conductance of Cells Expressing CFTRF508

Cystic Fibrosis / Drug Discovery / Cell line / Humans / cyclic AMP / Natural Product / Chloride Channel / Genistein / Biological Factors / Protein Binding / Electric Conductivity / Plasma Membrane / Chemical Structure / Biochemistry and cell biology / Dimerization / Natural Product / Chloride Channel / Genistein / Biological Factors / Protein Binding / Electric Conductivity / Plasma Membrane / Chemical Structure / Biochemistry and cell biology / Dimerization

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