Protein Kinase Inhibitors

Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

Organic Chemistry / Hydrogen / Pharmacokinetics / DNA damage / Signal Transduction / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / In Vitro / Protein Kinases / Mice / Animals / Bioavailability / In Vivo / Rats / Pyridines / Bioorganic and medicinal Chemistry / Pyrazoles / Cyanides / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

Contemporary management of sinonasal cancer

Dentistry / Quality of life / Radiation Therapy / Treatment Outcome / Endoscopy / Head and Neck / Humans / Monoclonal Antibodies / Clinical Sciences / Head / Survival Rate / Nasal cavity / Antineoplastic Agents / Protein Kinase Inhibitors / Lymph nodes / Head and Neck / Humans / Monoclonal Antibodies / Clinical Sciences / Head / Survival Rate / Nasal cavity / Antineoplastic Agents / Protein Kinase Inhibitors / Lymph nodes

3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor

Organic Chemistry / Dogs / Mice / Animals / Kinase inhibitor / Amides / Rats / Structure activity Relationship / Physical Properties / Protein Kinase Inhibitors / Molecular Structure / aniline Compounds / Amides / Rats / Structure activity Relationship / Physical Properties / Protein Kinase Inhibitors / Molecular Structure / aniline Compounds

Disclosure of erlotinib as a multikinase inhibitor in pancreatic ductal adenocarcinoma

Humans / Mice / Animals / Neoplasia / Clinical Sciences / Transfection / Protein Kinase Inhibitors / Adenocarcinoma / Quinazolines / Transfection / Protein Kinase Inhibitors / Adenocarcinoma / Quinazolines

Protein Kinase CK1 from Trypanosoma cruzi

Kinetics / Signal Transduction / Protein Kinases / Protein Chemistry / Animals / Phosphorylation / Enzyme / Trypanosoma Cruzi / Substrate Specificity / Molecular weight / Protein Phosphorylation / Protein Kinase / Amino Acid Sequence / Polyacrylamide Gel Electrophoresis / Protein Kinase Inhibitors / Biochemistry and cell biology / Phosphorylation / Enzyme / Trypanosoma Cruzi / Substrate Specificity / Molecular weight / Protein Phosphorylation / Protein Kinase / Amino Acid Sequence / Polyacrylamide Gel Electrophoresis / Protein Kinase Inhibitors / Biochemistry and cell biology

AZD7545, a novel inhibitor of pyruvate dehydrogenase kinase 2 (PDHK2), activates pyruvate dehydrogenase in vivo and improves blood glucose control in obese (fa/fa) Zucker rats

Obesity / Enzyme Inhibitors / Protein Kinases / Blood Glucose / Animals / Rats / Protein Kinase Inhibitors / Biochemistry and cell biology / Rats / Protein Kinase Inhibitors / Biochemistry and cell biology

Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors

Organic Chemistry / Signal Transduction / Cell line / In Vitro / Humans / Computer Simulation / Phosphorylation / Bioorganic and medicinal Chemistry / Growth Inhibition / Chemical Synthesis / Protein Kinase Inhibitors / Adenosine Triphosphate / Computer Simulation / Phosphorylation / Bioorganic and medicinal Chemistry / Growth Inhibition / Chemical Synthesis / Protein Kinase Inhibitors / Adenosine Triphosphate

IRAK-4 inhibitors. Part III: A series of imidazo[1,2-a]pyridines

Organic Chemistry / Signal Transduction / In Vitro / Kinase inhibitor / Pyridines / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

IRAK-4 inhibitors. Part III: A series of imidazo[1,2- a]pyridines

Organic Chemistry / Signal Transduction / In Vitro / Kinase inhibitor / Pyridines / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / Tnf alpha / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors

Organic Chemistry / Modeling / Pharmacokinetics / Pharmaceutical Chemistry / Signal Transduction / Crystal structure / X Rays / In Vitro / Humans / Animals / Drug Design / Kinase inhibitor / Design Rationale / In Vivo / Hydrazones / Rats / Oximes / Molecular Model / Molecular Conformation / Bioorganic and medicinal Chemistry / Growth Factor / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Receptor Tyrosine Kinase / Crystal structure / X Rays / In Vitro / Humans / Animals / Drug Design / Kinase inhibitor / Design Rationale / In Vivo / Hydrazones / Rats / Oximes / Molecular Model / Molecular Conformation / Bioorganic and medicinal Chemistry / Growth Factor / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Receptor Tyrosine Kinase

Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects

Cell line / Humans / Mutation / Microglia / Neurons / Haploinsufficiency / Frontotemporal Dementia / Induced Pluripotent Stem Cells / Staurosporine / Protein Kinase Inhibitors / Down-Regulation / Haploinsufficiency / Frontotemporal Dementia / Induced Pluripotent Stem Cells / Staurosporine / Protein Kinase Inhibitors / Down-Regulation

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