5,6-dihydro-α-pyrones and two bicyclic tetrahydro-α-pyrone derivatives from Cryptocarya latifolia

0031-9422(94)00828-0

Pergamon

Phytochemistr 3, Vol. 38, No. 6, pp. 1427 1430, 1995 Elsevier Science Ltd Printed in Great Britain 0031 9422/95 S9.50 + 0.00

5,6-DIHYDRO-~-PYRONES AND TWO BICYCLIC TETRAHYDRO-~-PYRONE DERIVATIVES FROM CR YPTOCAR YA LATIFOLIA

SIEGFRIED E. DREWES,* BETHUEL M. SEHLAPELO, MARION M. HORN, ROBERT SCOTT-SHAWt and PETER SANDOR~ Department of Chemistry and Chemical Technology, University of Natal, Pietermaritzburg, 3200, South Africa; ";'NatalParks Board, P.O. Box 662, Pietermaritzburg, South Africa; ++VarianGMBH, P.O. Box II1435, 64283 Darmstadt, Germany

(Received in revisedform 27 September 1994) Key Word Index--Cryptocarya latifolia; Lauraceae; bark; 6-substituted-5,6-dihydro-g-pyrones; bicyclic derivatives of tetrahydro-c(-pyrone; cryptocaryolone.

Abstract--Two new 6-substituted-5,6-dihydro-~-pyrones have been isolated from the bark Cryptocarya latifolia. In addition two new, closely related dioxabicyclo [3,3,1]nonan-2-one derivatives, have been obtained in lower concentration from the same plant source.

INTRODUCTION We have previously reported [ 1] on a novel 6-substituted 5,6-dihydro-~-pyrone, cryptofolione (1), isolated from two Cryptocarya species indigenous to South Africa. Further investigation into the constituents of C. latifolia has revealed the presence of additional 5,6-dihydro