A Convenient Synthetic Access to δ-Amino-γ,γ-difluoro-β-ketoesters

2002

oxocarboxylic acids and esters

oxocarboxylic acids and esters (benzene compounds) Q 0460 A Convenient Synthetic Access to δ-Amino-γ,γ-difluoro-β-ketoesters. 52 - 088 — A Reformatsky-type reaction of γ-bromo-β-ketoesters (I) with imines (II) is catalyzed by CuCl resulting in an efficient and practical access to the title compounds (III). — (WANG, YANLI; ZHU, SHIZHENG; Synthesis (2002) 13, 1813-1818; Shanghai Inst. Org. Chem., Chin. Acad. Sci., Shanghai 200032, Peop. Rep. China; EN)

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