A novel type of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid

Nucleic acids U 0700

44- 206

DOI: 10.1002/chin.201244206 A Novel Type of Acyclic Nucleoside Phosphonates Derived from 2-(Phosphonomethoxy)propanoic Acid. — A convenient and efficient synthesis of the potentially active title compounds is developed from the suitable compounds (I). The clean oxidation reaction (key step) tolerates the presence of the unprotected amino group at the C-6 position of the purine moiety. However the reaction of compounds, e.g. (Ie), which bear an amino group in C-2 position, give a complex mixture. None of the new compounds (III) show any interesting activity against HIV-1 or the other 12 tested viruses. — (KAISER, M. M.; JANSA, P.; DRACINSKY, M.; JANEBA*, Z.; Tetrahedron 68 (2012) 21, 4003-4012, http://dx.doi.org/10.1016/j.tet.2012.03.066 ; Inst. Org. Chem. Biochem., Acad. Sci. Czech Rep., CZ-166 10 Prague 6, Czech Republic; Eng.) — C. Gebhardt

ChemInform 2012, 43, issue 44

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