Bronchioloalveolar Lung Carcinoma

Bronchioloalveolar Lung Carcinoma : Results of Surgical Treatment and Prognostic Factors Jean François Regnard, Nicola Santelmo, Noureddine Romdhani, Noureddine Gharbi, Jacques Bourcereau, Elisabeth Dulmet and Philippe Levasseur Chest 1998;114;45-50 DOI 10.1378/chest.114.1.45 The online version of this article, along with updated information and services can be found online on the World Wide Web at: http://chestjournal.chestpubs.org/content/114/1/45

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Bronchioloalveolar Lung Carcinoma* Results of Surgical Treatment and Prognostic Factors

Jean Francois Regnard, MD; Nicola Santelmo, MD; Noureddine Romdhani, MD; Noureddine Gharbi, MD; Jacques Bourcereau, MD; Elisabeth Dulmet, MD; and

Philippe Levasseur, MD

Study design: To determine the long-term results after surgical treatment of bronchioloalveolar lung carcinoma (BALC) and to identify prognostic factors. Patients and methods: A retrospective study of 70 patients (49 men, 21 women), mean age 61 ±10 years, was carried out. Their carcinomas were classified into three clinicopathologic types: nodular or tumoral, pneumonic, and diffuse types. All the diagnosed BALC cases were reviewed and were classified into histologic types: mucinous, nonmucinous (including fibrotic center), and mixed tumors. Univariate and multivariate analyses were carried out. Results: The nodular or tumoral type was identified in 42 patients, pneumonic in 21, and diffuse in seven. Histologically, there were 36 mucinous, 25 nonmucinous, and nine mixed tumors. Resection was complete in 61 instances (87%) and incomplete in five. The 5-year survival rate was 34% in patients with curative resections. Five prognostic factors were identified by univariate analysis, but in multivariate analysis, only threeoffactors remained significant: the absence of symptoms, the TNM stage, and completeness resection. Thirty-six patients with curative resection (59%) developed recurrences (in the lung in 26 patients; mediastinal lymph nodes, four; distant metastases, nine). The frequency of recurrence was significantly greater in patients with pneumonic-type BALC than in nodular or tumoral types (p