ChemInform Abstract: Naphthoquinoidal [1,2,3]-Triazole, a New Structural Moiety Active Against Trypanosoma cruzi

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Other bioactive products U 1300 Naphthoquinoidal [1,2,3]-Triazole, a New Structural Moiety Active Against Trypanosoma cruzi. — Triazole derivatives (IV) of nor-β-lapachone are synthesized and 52- 201 tested against the infective bloodstream trypomastigote form of Trypanosoma cruzi. All derivatives are more active than the original quinones. The apolar phenyl-substituted triazole (IVe) is the most active compound. — (DA SILVA, E. N. J.; MENNA-BARRETO, R. F. S.; PINTO, M. D. C. F. R.; SILVA, R. S. F.; TEIXEIRA, D. V.; DE SOUZA, M. C. B. V.; DE SIMONE, C. A.; DE CASTRO*, S. L.; FERREIRA, V. F.; PINTO, A. V.; Eur. J. Med. Chem. 43 (2008) 8, 1774-1780; Lab. Biol. Celular, DUBC, Inst. Oswaldo Cruz, FIOCRUZ, 21045 Rio de Janeiro, Brazil; Eng.) — H. Toeppel

ChemInform 2008, 39, issue 46

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