ChemInform Abstract: Potential Anticancer Drugs. Part 2. Alkylating Agents from Sugars. Alkyl Hexopyranoside Derivatives as Carrier Systems for Chlorambucil

1999

carbohydrates

carbohydrates U 0500 Potential Anticancer Drugs. Part 2. Alkylating Agents from Sugars. 42 - 216 Alkyl Hexopyranoside Derivatives as Carrier Systems for Chlorambucil. — The title derivatives (IV), (VIII), and (XIII) in which the alkylating agent chlorambucil is linked at C-2 or C-3 of the sugar are synthesized by direct coupling, cf. (III) and (VII), or via a spacer, cf. (XII). The starting materials are easily available. The cytotoxicity of (IVb) and (VIII) is tested using two different procedures. The best inhibitor of cell proliferation is (IVb), making this compound a candidate for further studies in in vivo systems. — (IGLESIAS-GUERRA, FERNANDO; CANDELA, JOSE I.; BAUTISTA, JUAN; ALCUDIA, FELIPE; VEGA-PEREZ, JOSE M.; Carbohydr. Res. 316 (1999) 1-4, 71-84; Dep. Quim. Org. Farm., Fac. Farm., Univ. Sevilla, E-41071 Sevilla, Spain; EN)

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