www.jyoungpharm.in Vol 1, Issue 1, Jan-Mar, 2009
[ISSN : 0975-1483]
Journal of
Young Pharmacists
An Official Quarterly Publication of InPharm Association A Young Pharmacists Group of India [Formerly InPharm Communique]
Editorial • The Launch of J Young Pharm General • Emerging Opportunities in Pharma Industry Invited Article • Microcrystalline Cellulose as a Versatile Excipient in Drug Research Pharmaceutics • Colon Targeted Drug Delivery: Different Approaches • Buoyant Microspheres of Famotidine: An Approachable Dosage Form for Gastric Treatment • Development and Evaluation of Gelatin Microspheres of Tramadol Hydrochloride Pharmacognosy • Natural Products as Regulators of Progenitor Cells: Role in Cardiovascular Regenerative Medicine • Pharmacognostical Studies of Bauhinia variegata Linn root • Study on the Areca Nut for its Antimicrobial Properties • GC-MS Analysis of Propolis of Indian Origin • Pharmacognostical Studies and Evaluation of Anti-inflammatory Activity of Ficus bengalensis Linn Pharmacology • Gastroprotective Effect of Medicinal Plants from Chapada do Araripe, Brazil • Protective Effect of Polyherbal Formulation on Simvastatin Hepatotoxicity in Rats • Anti-inflammatory activity of Methanolic extracts of Dillenia indica L. leaves Pharmaceutical Chemistry • Licofelone- Novel Analgesic and Anti-Inflammatory Agent for Osteoarthritis: An Overview • Synthesis and Characterization of 2, 5-Disubstituted-1, 3, 4oxadiazoles as Potential Anti-inflammatory Agents • QSAR Analysis on ß-carboline as Antitumor Agent Pharmaceutical Analysis • Quantitative Estimation of Ascorbic Acid by HPTLC in different varieties of Amla Pharmaceutical Management • Prophylaxis in Migraine Management • Effective Tools of Pharma Counseling Instructions for Authors
A Young Pharmacists’ Group of India
www.inpharm.org
Empowering Young Pharmacists
Pharmacology
Gastroprotective Effect of Medicinal Plants from Chapada do Araripe, Brazil Gerlânia de Oliveira Leite1, Antonia Rosângela Soares Penha1, Glauberto Quirino da Silva1, Aracélio Viana Colares1, Fabíola Fernandes Galvão Rodrigues1, José Galberto Martins Costa1, André Luiz Herzog Cardoso2, Adriana Rolim Campos2 1
Technology Sciences Centre, State University of Ceará, Fortaleza, CE, Brazil, 2Vice-Rectory of Research and Post-Graduation, Fortaleza University, Fortaleza, CE, Brazil Address for correspondence: Dr. Adriana Rolim Campos; E-mail:
[email protected]
ABSTRACT Gastric ulcer is a serious gastrointestinal disorder that requires a well targeted therapeutic strategy. A number of drugs are available for the treatment of gastric ulcer, but clinical evaluation has shown incidence of relapses, side effects, and drug interactions. The search for novel molecules has been extended to herbal drugs that offer better protection and decreased relapse. The essential oils from Croton zehntneri (EOCZ) and Vanillosmopsis arborea (EOVA), the oil from Caryocar coriaceum pulp (OCC), the latex from Himatanthus drasticus (LHD), and the extract from Stryphnodendron rotundifolium (ESR) obtained from Chapada do Araripe, Ceará (Brazil) have been evaluated for cytoprotetive activity on ethanol-induced ulcer formation in mice. EOCZ, EOVA, OCC, and ESR were administrated by gavage at doses of 200 and 400 mg/kg and LDH, by the same way, at 0.2 and 0.4 mL/animal (n=8). Following 60 min, mice were given 0.2 mL of ethanol (96%) by gavage. Thirty minutes after the administration of ethanol, all groups were sacriÞced and the gastric ulcer index was calculated by planimetry. Preliminary results suggest that all the plants tested showed signiÞcant activity. EOVA (6.47±1.91%*), OCC (8.86±2.45%*) and ESR (1.50±0.30%**) were the most active. Data are expressed as mean±s.e.m. of the lesioned area (%) and were analyzed by ANOVA and Student-Newman-Keul´s test (*P
