Genomic Approaches to Trypanosomiasis Resistance

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Genomics approaches to trypanosomiasis resistance This image cannot currently be displayed.

Breeds of cattle which are resistant and susceptible to pathology following Trypanosoma congolense infection, show differences in gene expression following challenge. Examination of the networks of genes responding most differently between these genotypes provides insights into the biology of the response to infection. Agaba M1 Anderson S4 Archibald A4 Brass A2

Where differentially used networks include genes within QTL for resistance, those genes become functional candidates irrespective of whether they are differentially expressed themselves. The diversity of cattle and disease challenge across Africa provides a unique natural experiment which can be used to evaluate these genes for evidence of a functional role in trypanosome resistance. The responding networks provide new ways of examining the pathology, raising hypotheses and suggesting novel interventions which may be unrelated to the present diversity represented by the QTL. N’Dama (tolerant)

Boran (susceptible)

Gibson J5 Hall L4 Hanotte Hulme

O1

H2

Kemp SJ1,3 Mwakaya

J1

Noyes, HA3 Ogugo M1

15 10 5 0 -5 -10 -15

QTL with p